Patents by Inventor Gian Paolo Visentin

Gian Paolo Visentin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptide substrate for the detection of von Williebrand factor cleaving protease ADAMTS13
    Patent number: 10538802
    Abstract: In a first aspect, there is provided an isolated polypeptide substrate for a disintegrin-like and metallopeptidase with thrombospondin type-1 motif, 13 (ADAMTS13) that is from 45 to 70 amino acids in length and has an amino acid sequence that is substantially similar to part of the von Willebrand factor A2 domain sequence set forth in SEQ ID NO: 2, with one or more of the following modifications: (i) the amino acid corresponding to position 1599 of SEQ ID NO: 2 is mutated from Q to K; (ii) the amino acid corresponding to position 1610 of SEQ ID NO: 2 is mutated from N to C; and (iii) the amino acids corresponding to Q1624 to R1641 of SEQ ID NO: 2 are deleted.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: January 21, 2020
    Assignee: Immucor, Inc.
    Inventors: Gian Paolo Visentin, Suzette C. Chance, Elizabeth Wuitschick
  • POLYPEPTIDE SUBSTRATE FOR THE DETECTION OF VON WILLIEBRAND FACTOR CLEAVING PROTEASE ADAMTS13
    Publication number: 20190185905
    Abstract: In a first aspect, there is provided an isolated polypeptide substrate for a disintegrin-like and metallopeptidase with thrombospondin type-1 motif, 13 (ADAMTS13) that is from 45 to 70 amino acids in length and has an amino acid sequence that is substantially similar to part of the von Willebrand factor A2 domain sequence set forth in SEQ ID NO: 2, with one or more of the following modifications: (i) the amino acid corresponding to position 1599 of SEQ ID NO: 2 is mutated from Q to K; (ii) the amino acid corresponding to position 1610 of SEQ ID NO: 2 is mutated from N to C; and (iii) the amino acids corresponding to Q1624 to R1641 of SEQ ID NO: 2 are deleted.
    Type: Application
    Filed: December 20, 2018
    Publication date: June 20, 2019
    Inventors: Gian Paolo Visentin, Suzette C. Chance, Elizabeth Wuitschick
  • Polypeptide substrate for the detection of von Williebrand factor cleaving protease ADAMTS13
    Patent number: 10202633
    Abstract: In a first aspect, there is provided an isolated polypeptide substrate for a disintegrin-like and metallopeptidase with thrombospondin type-1 motif, 13 (ADAMTS13) that is from 45 to 70 amino acids in length and has an amino acid sequence that is substantially similar to part of the von Willebrand factor A2 domain sequence set forth in SEQ ID NO: 2, with one or more of the following modifications: (i) the amino acid corresponding to position 1599 of SEQ ID NO: 2 is mutated from Q to K; (ii) the amino acid corresponding to position 1610 of SEQ ID NO: 2 is mutated from N to C; and (iii) the amino acids corresponding to Q1624 to R1641 of SEQ ID NO: 2 are deleted.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: February 12, 2019
    Assignee: IMMUCOR GTI DIAGNOSTICS, INC.
    Inventors: Gian Paolo Visentin, Suzette C. Chance, Elizabeth Wuitschick
  • POLYPEPTIDE SUBSTRATE FOR THE DETECTION OF VON WILLIEBRAND FACTOR CLEAVING PROTEASE ADAMTS13
    Publication number: 20170145471
    Abstract: In a first aspect, there is provided an isolated polypeptide substrate for a disintegrin-like and metallopeptidase with thrombospondin type-1 motif, 13 (ADAMTS13) that is from 45 to 70 amino acids in length and has an amino acid sequence that is substantially similar to part of the von Willebrand factor A2 domain sequence set forth in SEQ ID NO: 2, with one or more of the following modifications: (i) the amino acid corresponding to position 1599 of SEQ ID NO: 2 is mutated from Q to K; (ii) the amino acid corresponding to position 1610 of SEQ ID NO: 2 is mutated from N to C; and (iii) the amino acids corresponding to Q1624 to R1641 of SEQ ID NO: 2 are deleted.
    Type: Application
    Filed: December 5, 2016
    Publication date: May 25, 2017
    Inventors: Gian Paolo VISENTIN, Suzette C. CHANCE, Elizabeth WUITSCHICK
  • Diagnostic devices, methods and systems for detecting platelet factor 4 (PF4)/heparin antibodies
    Patent number: 9599623
    Abstract: The present invention provides a novel assay for detecting human antibodies specific for a platelet factor 4 (PF4)/heparin complex in a fluid sample. The assay utilizes an immobilized PF4/polyanion complex and an anti-human antibody conjugated to a non-particulate fluorescent dye to capture and detect human PF4/heparin antibodies. Various devices, methods and systems based on the disclosed PF4/heparin assay are also provided.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: March 21, 2017
    Assignee: IMMUCOR GTI DIAGNOSTICS, INC.
    Inventors: Suzette Chance, Gian Paolo Visentin
  • Polypeptide substrate for the detection of von williebrand factor cleaving protease ADAMTS13
    Patent number: 9513290
    Abstract: In a first aspect, there is provided an isolated polypeptide substrate for a disintegrin-like and metallopeptidase with thrombospondin type-1 motif, 13 (ADAMTS13) that is from 45 to 70 amino acids in length and has an amino acid sequence that is substantially similar to part of the von Willebrand factor A2 domain sequence set forth in SEQ ID NO:2, with one or more of the following modifications: (i) the amino acid corresponding to position 1599 of SEQ ID NO: 2 is mutated from Q to K; (ii) the amino acid corresponding to position 1610 of SEQ ID NO: 2 is mutated from N to C; and (iii) the amino acids corresponding to Q1624 to R1641 of SEQ ID NO: 2 are deleted.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: December 6, 2016
    Assignee: IMMUCOR GTI DIAGNOSTICS, INC.
    Inventors: Gian Paolo Visentin, Suzette C. Chance, Elizabeth Wuitschick
  • POLYPEPTIDE SUBSTRATE FOR THE DETECTION OF VON WILLIEBRAND FACTOR CLEAVING PROTEASE ADAMTS13
    Publication number: 20150147764
    Abstract: In a first aspect, there is provided an isolated polypeptide substrate for a disintegrin-like and metallopeptidase with thrombospondin type-1 motif, 13 (ADAMTS13) that is from 45 to 70 amino acids in length and has an amino acid sequence that is substantially similar to part of the von Willebrand factor A2 domain sequence set forth in SEQ ID NO:2, with one or more of the following modifications: (i) the amino acid corresponding to position 1599 of SEQ ID NO: 2 is mutated from Q to K; (ii) the amino acid corresponding to position 1610 of SEQ ID NO: 2 is mutated from N to C; and (iii) the amino acids corresponding to Q1624 to R1641 of SEQ ID NO: 2 are deleted.
    Type: Application
    Filed: November 9, 2012
    Publication date: May 28, 2015
    Inventors: Gian Paolo Visentin, Suzette Chance, Elizabeth Wuitschick
  • DIAGNOSTIC DEVICES, METHODS AND SYSTEMS FOR DETECTING PLATELET FACTOR 4 (PF4)/HEPARIN ANTIBODIES
    Publication number: 20150064800
    Abstract: The present invention provides a novel assay for detecting human antibodies specific for a platelet factor 4 (PF4)/heparin complex in a fluid sample. The assay utilizes an immobilized PF4/polyanion complex and an anti-human antibody conjugated to a non-particulate fluorescent dye to capture and detect human PF4/heparin antibodies. Various devices, methods and systems based on the disclosed PF4/heparin assay are also provided.
    Type: Application
    Filed: June 5, 2012
    Publication date: March 5, 2015
    Inventors: Suzette Chance, Gian Paolo Visentin
  • Lateral flow assay device
    Patent number: D676570
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: February 19, 2013
    Assignee: Gen-Probe Incorporated
    Inventors: Suzette Chance, Gian Paolo Visentin, Keith Kopitzke, John Zeis