Abstract: Methods for treating a condition associated with proteoglycan production in a mammal are provided. The methods comprise the administration of at least one of a calmodulin antagonist, a transient receptor potential (TRP) channel inhibitor and a calmodulin-binding peptide to the mammal.

Abstract: A windowed immersive environment, particularly for use in training simulations provides a high degree of visual fidelity and realistic depth of vision at appropriate distances at a reasonable cost. The environment integrates physical components with virtual components to create a realistic visual environment. In one embodiment, a frame delineates a simulation space and a plurality of back-projection display screens mounted in the frame defines windows in the realistic visual environment. The world outside the windows is generated as 3D stereo images projected on to the screens to provide 3D virtual views. One or more frame elements define one or more non-windowed parts of the visual environment perceptually integrated with one or more of the 3D virtual views to provide the realistic visual environment.