Abstract: Process for preparing sterile suspensions for inhalation comprising an active ingredient insoluble in water and wherein at least 80% of the particles of said active ingredient have a diameter between 3 and 5 ?m, comprising the following stages: dissolving the active ingredient in the minimum quantity of an alcoholic solvent, optionally in the presence of a polyol and adding at least one surfactant, filtering the solution obtained in the previous stage through a sterilizing filter, adding the solution from stage (b) to sterile water under sonication to directly obtain a suspension wherein the particles have a reduced diameter.

Abstract: Process for preparing sterile suspensions for inhalation comprising an active ingredient insoluble in water and wherein at least 80% of the particles of said active ingredient have a diameter between 3 and 5 ?m, comprising the following stages: dissolving the active ingredient in the minimum quantity of an alcoholic solvent, optionally in the presence of a polyol and adding at least one surfactant, filtering the solution obtained in the previous stage through a sterilizing filter, adding the solution from stage (b) to sterile water under sonication to directly obtain a suspension wherein the particles have a reduced diameter.

Abstract: Process for preparing sterile suspensions for inhalation comprising an active ingredient insoluble in water and wherein at least 80% of the particles of said active ingredient have a diameter between 3 and 5 ?m, comprising the following stages: dissolving the active ingredient in the minimum quantity of an alcoholic solvent, optionally in the presence of a polyol and adding at least one surfactant, filtering the solution obtained in the previous stage through a sterilizing filter, adding the solution from stage (b) to sterile water under sonication to directly obtain a suspension wherein the particles have a reduced diameter.

Abstract: The use of nor- and homo-bile acids derivatives as absorption enhancers for medicaments is described. Said derivatives show the advantage of improving the absorption of medicaments through mucosae without being metabolized by the intestinal flora, thus allowing a fast excretion. Moreover, the derivatives of the invention have a negligible toxicity.

Abstract: A disposable inhaler (10; 50; 60) for administering medicaments in finely divided form contained in capsules (22) comprises a body (12) enclosing a nebulization chamber (20), the capsule being inserted into the nebulization chamber during assembly of the component parts of the inhaler. The inhaler does not comprise a device for piercing the capsule. This latter is pierced before its insertion into the inhaler. A cup is provided for preventing escape of the finely divided medicament through the capsule holes (42, 44) until the moment in which the inhaler is used.

Abstract: A liquid composition for nasal administration of polypeptide/s containing ammonium tartrate and a buffer together with optional adiuvants.

Abstract: An inhaler (10) for administering medicaments in finely divided form contained in capsules comprises a nebulization chamber (42) and a device (16) for piercing the capsule. That end surface of the nebulization chamber containing the holes (48, 49, 50) for the discharge of air laden with the finely divided medicament is shaped such that the capsule, when resting on it, does not impede air passage through any of the discharge holes. The nebulization chamber, at least in that part thereof closest to said discharge holes, tapers towards that end surface of the chamber comprising the discharge holes.