Patents by Inventor Giancarlo Grancini
Giancarlo Grancini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040043999Abstract: A process for preparing a compound of formula I: 1Type: ApplicationFiled: May 20, 2003Publication date: March 4, 2004Applicant: Zambon Group S.p.AInventors: Mauro Napoletano, Gabriele Norcini, Daniela Botta, Giancarlo Grancini, Gabriele Morazzoni, Francesco Santangelo, Jorge G. Siro Herrero, Jose Luis Garcia Navaio, Julio G. Alvarez-Builla
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Patent number: 6589951Abstract: Compounds of formula (I) wherein B is alkylene, amino, CONH or a bond; Cy is optionally substituted phenyl or heteroaryl; R is H, phenyl or (C1-4)alkyl optionally substituted; R1 is (C1-6)alkyl or polyfluoro(C1-6)-alkyl; R2 is (C4-7)cycloalkyl optionally containing an oxygen atom and optionally substituted; and the N→O derivatives and pharmaceutically acceptable salt thereof are PDE 4 and TNF&agr; inhibitors.Type: GrantFiled: August 10, 2000Date of Patent: July 8, 2003Assignee: Zambon Group S.p.A.Inventors: Mauro Napoletano, Gabriele Norcini, Daniela Botta, Giancarlo Grancini, Gabriele Morazzoni, Francesco Santangelo, Jorge G. Siro Herrero, José Luis Garcia Navaio, Julio G. Alvarez-Builla
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Patent number: 6498160Abstract: Phthalazine compounds having formula I wherein , A, B, R, R1, R2 and R3 are as defined herein, useful as phosphodiesterase 4 inhibitors.Type: GrantFiled: November 14, 2001Date of Patent: December 24, 2002Assignee: Zambon Group S.p.A.Inventors: Mauro Napoletano, Gabriele Norcini, Giancarlo Grancini, Franco Pellacini, Gabriele Morazzoni
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Patent number: 6492360Abstract: Compounds of formula (I), wherein is a single or double bond; Z is NH, methylene, a (C2-C6)alkylene chain optionally branched and/or unsaturated and/or interrupted by a (C5-C7)cycloalkyl residue; A is phenyl or heterocycle optionally substituted or a COR4 group wherein R4 is hydroxy, (C1-C6)-alkoxy, amino optionally substituted; R is a (C1-C6)alkyl or polyfluoro(C1-C6)alkyl group; R1 is absent when is a double bond or, when is a single bond, is (a) hydrogen; (b) (C1-C6)alkyl optionally substituted; (c) —COR6 wherein R6 is hydrogen, aryl, aryl-(C1-C6)alkyl, amino optionally alkylated or monohydroxylated, hydroxy, (C1-C4)alkoxy, carboxy, (C1-C4)alkoxycarbonyl, formula (1), or (C1-C4)alkyl optionally substituted by heterocycle; (d) (C1-C4)-alkylsulfonyl; R2 represents two hydrogen atoms or a group —O when is a single bond, or, when is a double bond, R2 is hydrogen, cyano, (C1-C4)alkoxycarbonyl, amido, optionally substituted aryl or heterocycle, (C1-C8)alkyl, (C2-C8)alkenyl or (Type: GrantFiled: October 15, 2001Date of Patent: December 10, 2002Assignee: Zambon Group S.p.A.Inventors: Mauro Napoletano, Gabriele Norcini, Giancarlo Grancini, Franco Pellacini, Gian Marco Leali, Gabriele Morazzoni
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Publication number: 20020058662Abstract: The present invention relates to phthalazine derivatives, pharmaceutical compositions containing them, and to their use as phosphodiesterase 4 inhbitors.Type: ApplicationFiled: November 14, 2001Publication date: May 16, 2002Applicant: ZAMBON GROUP S.P.A.Inventors: Mauro Napoletano, Gabriele Norcini, Giancarlo Grancini, Franco Pellacini, Gabriele Morazzoni
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Patent number: 6358973Abstract: Compounds of formula I: wherein A is a heterocycle containing a nitrogen atom and optionally saturated or unsaturated and optionally further substituted by an oxo group (═O); R is: hydrogen, cyano, (C1-4)alkoxycarbonyl, carbamoyl; optionally substituted (C4-7)-cycloalkyl, aryl or heterocycle; (C1-8)alkyl, (C2-8)alkenyl or (C2-8)alkynyl optionally branched and/or substituted by (C4-7) cycloalkyl, aryl or heterocycle; aryloxy, heterocyclyloxy, aryl(C1-4)alkoxy, heterocyclyl(C1-4)alkoxy, amino substituted by one or two (C1-4)alkyl group(s), aryl-amino, heterocyclyl-amino, aryl(C1-4)alkyl-amino, or heterocyclyl(C1-4)alkylamino; Y is methylene or ethylene; W is an optionally substituted aryl or heterocycle; R1 is hydrogen, (C4-7)cycloalkyl or a (C2-8)alkyl, (C2-8)alkenyl or (C2-8)alkynyl group optionally substituted by hydroxy, oxo, (C4-7)cycloalkyl, aryl or heterocycle, and optionally interrupted by one or more heteroatom(s) or heterogroup(s); R2 is a (C1-6)alkyl or polyfluoro(C1-6)alkyl grType: GrantFiled: April 13, 2001Date of Patent: March 19, 2002Assignee: Zambon Group S.p.A.Inventors: Mauro Napoletano, Gabriele Norcini, Giancarlo Grancini, Franco Pellacini, Gabriele Morazzoni, Lorenzo Pradella
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Patent number: 6340684Abstract: The present invention provides a compound selected from the group including: N-3-acetyl-1-(3,5-dichloropyridin-4-ylmethyl)-5-cyclopentyloxy-6-methoxy-4H-phthalazine; 6,7-dimethoxy-1-pyridin-4-ylmethyl-4-thiazol-2-yl-phthalazine; 1-(6,7-dimethoxy-4-pyridin-4-ylmethyl-1H-phthalazin-2-yl)ethanone; 2-methanesulphonyl-6,7-dimethoxy-4-pyridin-4-ylmethyl-1,2-dihydrophthalazine; 2-formyl-6,7-dimethoxy-4-pyridin-4-ylmethyl-1,2-dihydrophthalazine; 1-(6,7-dimethoxy-4-pyridin-4-ylmethyl-1H-phthalazin-2-yl)-1-imidazol-1-ylmethanone; 1-(3,5-dichloro-pyridin-4-ylmethyl)-3-methansulphonyl-6-difluoromethoxy-5-(tetrahydro-furan-2-yloxy)-4H-phthalazine; N→O derivatives thereof; and pharmaceutically acceptable salts thereof. The invention also provides a pharmaceutical composition, which contains a therapeutically effective amount of the above compound in admixture with a pharmaceutically acceptable carrier.Type: GrantFiled: January 22, 2001Date of Patent: January 22, 2002Assignee: Zambon Group S.p.A.Inventors: Mauro Napoletano, Gabriele Norcini, Giancarlo Grancini, Franco Pellacini, Gabriele Morazzoni
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Patent number: 6329370Abstract: The present invention provides a compound selected from the group including: 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-4-phenyl-phthalazine; 4-(3,5-dichloro-pyridin-4-ylmethyl)-7-methoxy-1H-phthalazin-2-carboxylic acid methyl ester; benzyl-{3-{1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-phthalazin-5-yl}-prop-2-ynyl}-methyl-amine; 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-5-(5-morpholin-4-yl-pent-1-ynyl)-phthalazine dihydrochloride; 3-{1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-phthalazin-5-yl}-prop-2-yn-1-ol; 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-4-morpholin-4-yl-phthalazine; 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-4-(1,2,4)triazol-1-yl-phthalazine; N→O derivatives thereof; and pharmaceutically acceptable salts thereof. The invention also provides a pharmaceutical composition which includes a therapeutically effective amount of the above compound in admixture with a suitable carrier.Type: GrantFiled: January 22, 2001Date of Patent: December 11, 2001Assignee: Zambon Group S.p.A.Inventors: Mauro Napoletano, Gabriele Norcini, Giancarlo Grancini, Franco Pellacini, Gian Marco Leali, Gabriele Morazzoni
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Patent number: 6297257Abstract: Compounds of formula (I) wherein A is an orthocondensed heterocycle optionally substituted by certain substituents and necessarily substituted by a —B—Cy group where the variables are as defined in the specification and the N→O derivatives and pharmaceutically acceptable salts thereof are phosphodiesterase-4 inhibitors.Type: GrantFiled: July 13, 2000Date of Patent: October 2, 2001Assignee: Zambon Group S.p.A.Inventors: Mauro Napoletano, Gabriele Norcini, Daniela Botta, Giancarlo Grancini, Gabriele Morazzoni
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Patent number: 6232348Abstract: Compounds of formula (I) wherein R, R′, R″, R1, R2, R3, R4, R5, R6, X, Y, m, n, and p have the meanings reported in the description; and their pharmaceutically acceptable salts are described.Type: GrantFiled: August 12, 1999Date of Patent: May 15, 2001Assignee: Zambon Group S.p.A.Inventors: Stefania Montanari, Paolo Cavalleri, Francesco Santangelo, Cristina Fraire, Giancarlo Grancini, Napoletano Mauro, Francesco Marchini, Lorenzo Pradella, Claudio Semeraro
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Patent number: 6211387Abstract: A compound of formula (II), wherein R1 is chloro, fluoro or trifluoromethyl; R2 is hydrogen, chloro, fluoro or trifluoromethyl; and R is hydrogen or a protective group for the hydroxy moiety useful as an intermediate for the synthesis of antimycotic azole compounnds.Type: GrantFiled: June 5, 2000Date of Patent: April 3, 2001Assignee: Zambon Group S.p.A.Inventors: Mauro Napoletano, Marco Villa, Aldo Belli, Giancarlo Grancini, Biase Continanza
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Patent number: 4766138Abstract: Use of 4-(isoxazolyl)-thiazole-2-oxamic acid derivatives; method for preparing them and intermediate compounds useful for their preparation.Said compounds possess antiarthritic activity; compositions for pharmaceutical use containing said compounds as the active ingredients are also described.Type: GrantFiled: March 13, 1986Date of Patent: August 23, 1988Assignee: Zambon S.p.A.Inventors: Angelo Carenzi, Dario Chiarino, Davide Della Bella, Giancarlo Grancini
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Patent number: 4766137Abstract: 4-(isoxazolyl)-thiazole-2-oxamic acids, esters and salts thereof; method for preparing them and intermediate compounds useful for their preparation.Said compounds possess antiallergic and antianaphylactic activity and may be used in the pharmaceutical field.Compositions for pharmaceutical use containing said compounds as the active ingredients are also described.Type: GrantFiled: March 13, 1986Date of Patent: August 23, 1988Assignee: Zambon S.p.A.Inventors: Angelo Carenzi, Dario Chiarino, Davide Della Bella, Giancarlo Grancini