Patents by Inventor Gianfranco Alpini

Gianfranco Alpini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for treating liver disease
    Patent number: 11318190
    Abstract: Disclosed is a method of modulating the Sct/SR axis in a mammalian subject in need thereof, including in a subject suffering from a liver disease, such as but not limited to, Early Stage PBC, Primary Sclerosing Cholangitis, Primary Biliary Cholangitis, Biliary Altresia, NASH, NAFLD, or Alcohol induced liver injury. A method of treating Late Stage PBC in a mammalian subject in need thereof is also disclosed; further disclosed is a method of ameliorating PBC-induced biliary damage in a mammalian subject in need thereof. Pharmaceutical compositions for modulating the Sct/SR axis, comprising a SR antagonist or a SR agonist, and a pharmaceutically acceptable carrier or excipient are also disclosed.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: May 3, 2022
    Assignee: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Gianfranco Alpini, Shannon Glaser, Fanyin Meng
  • METHODS AND COMPOSITIONS FOR TREATING LIVER DISEASE
    Publication number: 20200078445
    Abstract: Disclosed is a method of modulating the Sct/SR axis in a mammalian subject in need thereof, including in a subject suffering from a liver disease, such as but not limited to, Early Stage PBC, Primary Sclerosing Cholangitis, Primary Biliary Cholangitis, Biliary Atresia, NASH, NAFLD, or Alcohol induced liver injury. A method of treating Late Stage PBC in a mammalian subject in need thereof is also disclosed; further disclosed is a method of ameliorating PBC-induced biliary damage in a mammalian subject in need thereof. Pharmaceutical compositions for modulating the Sct/SR axis, comprising a SR antagonist or a SR agonist, and a pharmaceutically acceptable carrier or excipient are also disclosed.
    Type: Application
    Filed: April 5, 2018
    Publication date: March 12, 2020
    Inventors: Gianfranco Alpini, Shannon Glaser, Fanylin Meng
  • Melatonin-based treatment and diagnosis of bile duct disease
    Patent number: 9468670
    Abstract: Methods and composition for a melatonin signaling modulator-based diagnosis and therapy are described. For example, in certain aspects methods for administering an anti-tumor therapy using a melatonin signaling modulator are described. Furthermore, the invention provides compositions and methods for detecting biliary tract disease such as cholangiocarcinoma.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: October 18, 2016
    Assignees: Texas A&M University System, The United States of America as Represented by the Department of Veterans Affairs, Scott & White Healthcare
    Inventors: Gianfranco Alpini, Sharon DeMorrow, Shannon Glaser
  • MELATONIN-BASED TREATMENT AND DIAGNOSIS OF BILE DUCT DISEASE
    Publication number: 20140079680
    Abstract: Methods and composition for a melatonin signaling modulator-based diagnosis and therapy are described. For example, in certain aspects methods for administering an anti-tumor therapy using a melatonin signaling modulator are described. Furthermore, the invention provides compositions and methods for detecting biliary tract disease such as cholangiocarcinoma.
    Type: Application
    Filed: April 2, 2012
    Publication date: March 20, 2014
    Applicant: SCOTT & WHITE HEALTHCARE
    Inventors: Gianfranco Alpini, Sharon DeMorrow, Shannon Glaser