Abstract: Depolymerization of stabilized solutions of highly polymerized and nicked polydeoxyribonucleotides, as obtained through stabilizing aggregation of raw nucleic acids, the depolymerization being carried out by heating at controlled temperature and being controlled as a function of the variation of the reversible hyperchromicity, followed by the removal of the hydrogen bonds in the double stranded filaments and by thermal stabilization of the single stranded filaments, polydeoxyribonucleotide is obtained. The polydeoxyribonucleotide has the following formula of random sequence:P.sub.1-5, (dAp).sub.12-24, (dGp).sub.10-20, (dTp).sub.13-26, (dCp).sub.10-20,whereinP=phosphoric radicaldAp=deoxyadenylic monomerdGp=deoxyguanylic monomerdTp=deoxythymidylic monomerdCp=deoxycytidylic monomerand has well defined chemico-physical properties, reproducible in industrial production.

Abstract: By carrying out the depolymerization of stabilized solutions of highly polymerized and nicked polydeoxyribonucleotides, as obtained through stabilizing aggregation of raw nucleic acids, the depolymerization being carried out by heating at controlled temperature and being controlled as a function of the variation of the reversible hyperchromicity, followed by the removal of the hydrogen bonds in the double stranded filaments and by thermal stabilization of the single stranded filaments, the polydeoxyribonucleotide, known as Defibrotide is obtained. Defibrotide has the following formula of random sequence:P.sub.1-5,(dAp).sub.12-24,(dGp).sub.10-20, (dTp).sub.13-26,(dCP).sub.10-20,whereinP=phosphoric radicaldAp=deoxyadenylic monomerdGp=deoxyguanylic monomerdTp=deoxythymidylic monomerdCp=deoxycytidylic monomerand has well defined chemico-physical properties, reproducible in the industrial production.

Abstract: Tetrachlorobenzoic acid derivative having the formula: ##STR1## (2-trichloroacetoxy-3,4,5,6-tetrachlorobenzoic acid), chemotherapeutically active against cutaneous and subcutaneous benign neoformations, process for its preparations and compositions containing the same.

Abstract: A oligo-heteropolysaccharide is disclosed which is very active against thrombotic syndromes and is prepared starting from depolymerized heparin fractions wherein the active groups, more particularly the sulfuric groups have been reconstituted by reacting a heparin fraction with a mol wt from 2,000 to 5,000 with the sulfotrioxide of a nitrogeneous organic base such as pyridine and trimethylamine. The method of preparation is also disclosed.

Abstract: An arterial polysaccharide complex of anionic character consisting of hexosamine glycanmonosulphates (FAPA) derived from the aorta of young mammals and a process for its preparation.

Abstract: Natural heteropolysaccharide, specifically hexuronyl hexosaminoglycane sulfate and, a process to obtain it, which substantially provides for the following steps:(a) hydrolysis of an animal organ with a proteolytic enzyme, in water;(b) precipitation of the hydrolyzed product with a water miscible solvent;(c) solubilization of the precipitate in a solution of a salt of a strong mineral acid;(d) addition of a quaternary ammonium halide to form a soluble complex and a precipitate which is separated;(e) precipitation of such complex by dilution with water;(f) isolation and solubilization of the precipitated complex in a salt solution according to step (c);(g) precipitation of the final product with a water miscible solvent and drying thereof;Such compound is utilized as active principle in pharmaceutical compositions, particularly suitable for the prevention of thrombotic states.

Abstract: Natural heteropolysaccharide, specifically hexuronyl hexosaminoglycane sulfate and, a process to obtain it, which substantially provides for the following steps:(a) hydrolysis of an animal organ with a proteolytic enzyme, in water;(b) precipitation of the hydrolyzed product with a water miscible solvent;(c) solubilization of the precipitate in a solution of a salt of a strong mineral acid;(d) addition of a quaternary ammonium halide to form a soluble complex and a precipitate which is separated;(e) precipitation of such complex by dilution with water;(f) isolation and solubilization of the precipitated complex in a salt solution according to step (c);(g) precipitation of the final product with a water miscible solvent and drying thereof;Such compound is utilized as active principle in pharmaceutical compositions, particularly suitable for the prevention of thrombotic states.

Abstract: Protease inhibitor is extracted from fresh or frozen organs of slaughtered animals by an enzymolysis operation which excludes any possibility of interference by azymic autolysis, the enzymolysis being stopped after a time not exceeding 4 hours, whereafter a lysate aqueous solution is obtained by filtration and a quaternary ammonium base is added to the lysate solution to precipitate insolubles, the filtrate being the fraction which contains the expected protease inhibitor.

Abstract: From the residual liquors of the extraction of active principles, particularly heparin, from animal organs, a fraction of natural polyanions is obtained having, besides clearing and anticoagulant activity, also antiphlogistic and anti-inflammatory activity as well as stimulating activity on the reticuloendothelial system, whereby it is useful in the treatment of atherosclerosis and related diseases. The process for obtaining these natural polyanions is also disclosed.