Patents by Inventor Giang Thanh Le
Giang Thanh Le has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8563562Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.Type: GrantFiled: September 13, 2012Date of Patent: October 22, 2013Assignee: Avexa LimitedInventors: John Joseph Deadman, Eric Dale Jones, Giang Thanh Le, David Ian Rhodes, Neeranat Theinthong, Nicholas Andrew Van de Graff, Lisa Jane Winfield
-
Publication number: 20130178469Abstract: The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof.Type: ApplicationFiled: July 15, 2011Publication date: July 11, 2013Applicants: SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (SIOC), AVEXA LIMITEDInventors: David Ian Rhodes, John Joseph Deadman, Giang Thanh Le, Nicholas Andrew Van de Graff, Lu Long, Li Xinming, Feng Xiao, Yu Changjiang
-
Patent number: 8431581Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.Type: GrantFiled: July 2, 2009Date of Patent: April 30, 2013Assignee: Avexa LimitedInventors: John Joseph Deadman, Eric Dale Jones, Giang Thanh Le, David Ian Rhodes, Neeranat Thienthong, Nicholas Andrew Van de Graff, Lisa Jane Winfield
-
Patent number: 8426405Abstract: Compounds of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof are disclosed. Also disclosed are methods of treating a viral infection in a subject by administering to the subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.Type: GrantFiled: July 2, 2009Date of Patent: April 23, 2013Assignee: Avexa LimitedInventors: John Joseph Deadman, Eric Dale Jones, Giang Thanh Le, David Ian Rhodes, Neeranat Thienthong, Nicholas Andrew Vandegraaff, Lisa Jane Winfield
-
Publication number: 20130059865Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.Type: ApplicationFiled: September 13, 2012Publication date: March 7, 2013Applicant: AVEXA LIMITEDInventors: John Joseph Deadman, Eric Dale Jones, Giang Thanh Le, David Ian Rhodes, Neeranat Theinthong, Nicholas Andrew Van de Graff, Lisa Jane Winfield
-
Patent number: 8222381Abstract: New compounds and methods for the preparation of combinatorial libraries of potentially biologically active compounds are based on monosaccharides of formula I being a derivative of a furanose or pyranose form of a monosaccharide, .Type: GrantFiled: August 8, 2003Date of Patent: July 17, 2012Assignee: Alchemia LimitedInventors: Michael West, Peter Andrews, Tracie Elizabeth Ramsdale, Wim Meutermans, Giang Thanh Le, Chris Clark, Giovanni Abbenante, Ligong Liu
-
Publication number: 20110281861Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.Type: ApplicationFiled: July 2, 2009Publication date: November 17, 2011Inventors: John Joseph Deadman, Eric Dale Jones, Giang Thanh Le, David Ian Rhodes, Neeranat Thienthong, Nicholas Andrew Vandegraaff, Lisa Jane Winfield
-
Publication number: 20110201794Abstract: Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.Type: ApplicationFiled: December 17, 2010Publication date: August 18, 2011Applicant: Alchemia LimitedInventors: Wim Meutermans, Michael L. West, George Adamson, Giang Thanh Le, Nicholas B. Drinnan, Giovani Abbenante, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam, Gerald Tometzki
-
Patent number: 7989422Abstract: The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as described herein:Type: GrantFiled: December 20, 2006Date of Patent: August 2, 2011Assignee: Alchemia LimitedInventors: Wim Meutermans, Declan McKeveney, Johannes Zuegg, Rajaratnam Premraj, Craig Muldoon, Giang Thanh Le
-
Publication number: 20110165700Abstract: A method of inhibiting or effecting the activity of an integrin receptor comprises contacting an integrin with a pyranose of formula I, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: March 14, 2011Publication date: July 7, 2011Applicant: Alchemia LimitedInventors: Wim MEUTERMANS, Michael L. West, Giang Thanh Le, Judy Halliday, Christopher Clark
-
Publication number: 20110039842Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.Type: ApplicationFiled: July 2, 2009Publication date: February 17, 2011Inventors: John Joseph Deadman, Eric Dale Jones, Giang Thanh Le, David Ian Rhodes, Neeranat Theinthong, Nicholas Andrew Van de Graff, Lisa Jane Winfield
-
Publication number: 20110028487Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.Type: ApplicationFiled: July 2, 2009Publication date: February 3, 2011Applicant: AVEXA LIMITEDInventors: John Joseph Deadman, Eric Dale Jones, Giang Thanh Le, David Ian Rhodes, Neeranat Thienthong, Nicholas Andrew Van De Graff, Lisa Jane Winfield
-
Patent number: 7875707Abstract: Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.Type: GrantFiled: April 24, 2003Date of Patent: January 25, 2011Assignee: Alchemia LimitedInventors: Wim Meutermans, Michael West, George Adamson, Giang Thanh Le, Nicholas B. Drinnan, Giovanni Abbenante, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam, Gerald Tometzki
-
Publication number: 20090023669Abstract: The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as described herein:Type: ApplicationFiled: December 20, 2006Publication date: January 22, 2009Applicant: Alchemia LimitedInventors: Wim Meutermans, Declan McKeveney, Johannes Zuegg, Rajaratnam Premraj, Craig Muldoon, Giang Thanh Le
-
Publication number: 20080176936Abstract: A method of inhibiting or effecting the activity of an integral receptor which comprises contacting an integrin with a compound of formula I, or a pharmaceutically acceptable salt thereof; General Formula I Wherein the ring may be of any configuration; Z is sulphur, oxygen, CH2, NH, NRA or hydrogen, in the case where Z is hydrogen then R1 is not present, RA is selected from the set defined for R1 to R5, X is oxygen or NRA providing that at least one X of General Formula I is NRA, X may also combine independently with one of R1 to R5 to form an azide, R1 to R5 are independently selected from the group comprising H, —(CO)R6 or an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear wherein substituents may optionally be further substituted, wherein R6 is selected from the group comprising an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl sType: ApplicationFiled: February 2, 2006Publication date: July 24, 2008Inventors: Wim Meutermans, Michael L. West, Giang Thanh Le, Judy Halliday, Christopher Clark
-
Publication number: 20060167237Abstract: New compounds and methods for the preparation of combinatorial libraries of potentially biologically active compounds are based on monosaccharides of formula I being a derivative of a furanose or pyranose form of a monosaccharide,Type: ApplicationFiled: August 8, 2003Publication date: July 27, 2006Applicant: ALCHEMIA LIMITEDInventors: Michael West, Peter Andrews, Tracie Ramsdale, Wim Meutermans, Giang Thanh Le, Chris Clark, Giovanni Abbenante, Ligong Liu
-
Publication number: 20060121530Abstract: Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.Type: ApplicationFiled: April 24, 2003Publication date: June 8, 2006Inventors: Wim Meutermans, Michael West, George Adamson, Giang Thanh Le, Nicholas Drinnan, Giovani Abbenante, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam, Gerald Tometzki