Abstract: A compound of general formula (I): in which: R is selected from the group consisting of (C1-C25)alkyl, (C2-C25)alkenyl, aryl, (C7-C10)aralkyl; n and m are each independently an integer of two to eight; p is one or two; A is selected from the group consisting of —B—, —B—(CH2)r—B—, —B—(CH2)r—B—(CH2)z—B—, wherein r and z are an integer from 2 to 8, B is a —NR1— or —N(R2)2+1/pQ?p group, in which R1 is selected from hydrogen, (C1-C4)alkyl, (C1-C4)acyl, tert-butoxycarbonyl, and R2 is selected from hydrogen and (C1-C4)alkyl; Q?p is an anion selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R3COO? wherein R3 has the same meanings as R, independently from one another and R4—O—SO3? wherein R4 is (C2-C14)alkyl with the proviso that, when Q?p is selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R is not (C1-C4)alkyl.

Abstract: The present invention relates to the antitumor compound of formula (I) a process for its preparation and pharmaceutical compositions containing it.

Abstract: The invention relates to an improved process for the preparation of poly-?-glutamic acids which comprises the polymerization of tertiary ?-esters of ?-glutamic acid N-carboxy anhydride with appropriate solvents and initiators, followed by acid hydrolysis of the resulting poly-?-glutamic acid-?-ester. The process is particularly advantageous in that it allows one to carefully control the molecular weight of the resulting poly-?-glutamic acid. The invention also relates to poly-?-glutamic acids capped at the amino terminus with carboxylic acids or amino acids and to a process for the preparation thereof.

Abstract: The invention relates to an improved process for the preparation of poly-?-glutamic acids which comprises the polymerization of tertiary ?-esters of ?-glutamic acid N-carboxy anhydride with appropriate solvents and initiators, followed by acid hydrolysis of the resulting poly-?-glutamic acid-?-ester. The process is particularly advantageous in that it allows one to carefully control the molecular weight of the resulting poly-?-glutamic acid. The invention also relates to poly-?-glutamic acids capped at the amino terminus with carboxylic acids or amino acids and to a process for the preparation thereof.

Abstract: A compound of general formula (I): in which: R is selected from the group consisting of (C1-C25)alkyl, (C2-C25)alkenyl, aryl, (C7-C10)aralkyl; n and m are each independently an integer of two to eight; p is one or two; A is selected from the group consisting of —B—, —B—(CH2)r—B—, —B—(CH2)r—B—(CH2)z—B—, wherein r and z are an integer from 2 to 8, B is a —NR1— or —N(R2)2+ 1/pQ?p group, in which R1 is selected from hydrogen, (C1-C4)alkyl, (C1-C4)acyl, tert-butoxycarbonyl, and R2 is selected from hydrogen and (C1-C4)alkyl; Q?p is an anion selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R3COO? wherein R3 has the same meanings as R, independently from one another and R4—O—SO3? wherein R4 is (C2-C14)alkyl with the proviso that, when Q?p is selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R is not (C1-C4)alkyl.

Abstract: 3H-Benzo[e]indol-4,5-dione derivatives with antitumor activity, the processes for the preparation thereof and pharmaceutical compositions containing them.

Abstract: The invention relates to an improved process for the preparation of poly-?-glutamic acids which comprises the polymerization of tertiary ?-esters of ?-glutamic acid N-carboxy anhydride with appropriate solvents and initiators, followed by acid hydrolysis of the resulting poly-?-glutamic acid-?-ester. The process is particularly advantageous in that it allows one to carefully control the molecular weight of the resulting poly-?-glutamic acid. The invention also relates to poly-?-glutamic acids capped at the amino terminus with carboxylic acids or amino acids and to a process for the preparation thereof.