Abstract: A method for producing an image of a vessel with ultrasound includes administering a contrast agent particle into the vessel and delivering an ultrasound pulse having a first frequency range to the vessel. The method further includes detecting ultrasound energy scattered from the contrast agent particle at a second frequency range, converting the scattered ultrasound energy into an electronic radio frequency signal, and using an algorithm to determine a spatial location of the contrast agent particle based on extraction of a specific feature of the radio frequency signal. The method further includes generating an image by displaying a marker of the spatial location of the contrast agent particle with a resolution that is finer than a pulse length of the ultrasound pulse and repeating the steps for different contrast agent particles until sufficient markers have been accumulated to reconstruct a pattern of the vessel.

Abstract: A method for producing an image of at least one vessel with ultrasound includes administering a contrast agent particle into the at least one vessel, and delivering an ultrasound pulse having a first frequency range to the at least one vessel. The method further includes detecting ultrasound energy scattered from the contrast agent particle at a second frequency range that is different from the first frequency range, converting the scattered ultrasound energy into an electronic radio frequency signal, and using an algorithm to determine a spatial location of the contrast agent particle based on extraction of a specific feature of the radio frequency signal.

Abstract: Disclosed is a method and related systems comprising detecting a position of each of two or more targets in a volume to be imaged; generating and directing a single beam of ultrasound energy toward the volume by simultaneously focusing the single beam on each of the two or more the target positions; detecting the ultrasound energy from each of the two or more the target positions; and using the detected ultrasound energy to generate an image of the volume to be imaged. Such as generating a blood flow profile in a blood vessel.