Abstract: A cartridge assembly for a filling machine includes a plurality of containers. Each container includes a volume and a stem connected to the volume. A connection line grid is in fluid communication with each stem of the plurality of containers. The connection line grid includes a first row connected to one or more containers of the plurality of containers and a second row connected to one or more containers of the plurality of containers. A filter assembly is coupled to the connection line grid.

Abstract: A method for producing sterile solution-filled containers includes positioning a cartridge onto a filling machine. The cartridge includes a plurality of containers, a filter assembly, and a connection line in fluid communication with the filter assembly. Each of the plurality of containers includes a volume and a stem in fluid communication with the volume and in fluid communication with the connection line. The method includes coupling the cartridge to a feed line in fluid communication with a mix tank, activating a pump coupled to the feed line, and at least partially filling one or more of the volumes associated with the plurality of containers by pumping fluid through the feed line, the filter assembly, and the connection line to create one or more at least partially filled containers. Further, the method includes sealing and separating each of the filled and sealed containers from the connection line.

Abstract: A multiple chamber container forming and filling method includes (i) forming at least one strong seal around a periphery of first and second sheets so as to leave an opening between the first and second sheets; (ii) forming a temporary peel seal across the opening; (iii) forming a mixing peel seal between the first and second sheets so as to separate a diluent chamber from a powdered drug chamber; (iv) adding diluent to the diluent chamber; (v) sterilizing the multiple chamber container including the diluent; (vi) opening the temporary peel seal in an aseptic environment; (vii) adding powdered drug to the powdered drug chamber through the opening; and (viii) strong sealing the opening so as to be closed.

Abstract: A multiple chamber container forming and filling method includes (i) forming at least one strong seal around a periphery of first and second sheets so as to leave an opening between the first and second sheets; (ii) forming a temporary peel seal across the opening; (iii) forming a mixing peel seal between the first and second sheets so as to separate a diluent chamber from a powdered drug chamber; (iv) adding diluent to the diluent chamber; (v) sterilizing the multiple chamber container including the diluent; (vi) opening the temporary peel seal in an aseptic environment; (vii) adding powdered drug to the powdered drug chamber through the opening; and (viii) strong sealing the opening so as to be closed.

Abstract: A multiple chamber container includes a first sheet; a second sheet; a first peel seal between the first and second sheets, the first peel seal extending across the first and second sheets; wherein at a first time at least one strong seal is provided around a periphery of the first and second sheets so as to leave an opening between the first and second sheets, and wherein a second peel seal is provided between the first and second sheets, the second peel seal extending across the opening between the first and second sheets; and wherein at a second time the second peel seal is removed and the at least one strong seal is extended to seal the opening between the first and second sheets.

Abstract: A flow control clamp having a first member and a second member movable from a first open position to a second irreversibly closed position wherein flow through a tube associated with the clamp is irreversibly prevented and cannot be restored. Systems and methods using such clamps are also disclosed.

Abstract: A flow control clamp having first and second legs disposed in a generally facing relationship. The clamp includes apertures receiving a flexible tube therethrough. The first and second legs include surfaces disposed to irreversibly secure the legs together in the closed position.

Abstract: A port assembly includes a valve housing with an inlet opening, a valve disposed in the valve housing to control access through the inlet opening, and a base joined to the valve housing and having a bore therethrough. The bore has a closed end defined by a frangible barrier, and a pushrod is disposed in the bore between the valve and the frangible barrier, axial movement of the pushrod causing rupture of the frangible barrier. The port assembly may be used in a fluid container that includes a receptacle for retaining a fluid, and at least one conduit in communication with the receptacle. The at least one conduit is defined, at least in part, by a port assembly.

Abstract: A port assembly includes a housing with an opening and a bore therethrough, a slit septum disposed in the bore to control access through the opening, a base joined to the housing and having a membrane attached thereto, a perforator having a first end abutting the slit septum and a second end aligned with the membrane, and a resilient member disposed between the perforator and the base. The port assembly may be used in a fluid container that includes a receptacle for retaining a fluid, and at least one conduit in communication with the receptacle. The at least one conduit may be defined, at least in part, by the port assembly.

Abstract: A port assembly includes a valve housing with an inlet opening, a valve disposed in the valve housing to control access through the inlet opening, and a base having an outlet opening that is initially occluded by a membrane. A pivot is disposed within the base and has a cutting surface disposed within the base, the cutting surface rupturing the membrane at least in part as the pivot is pivoted about an axis between first and second positions. The port assembly may be used in a fluid container that includes a receptacle for retaining a fluid, and at least one conduit in communication with the receptacle. The at least one conduit is defined, at least in part, by the port assembly.

Abstract: A port assembly includes a housing with an opening and a bore therethrough, a slit septum disposed in the bore to control access through the opening, a base joined to the housing and having a membrane attached thereto, a perforator having a first end abutting the slit septum and a second end aligned with the membrane, and a resilient member disposed between the perforator and the base. The port assembly may be used in a fluid container that includes a receptacle for retaining a fluid, and at least one conduit in communication with the receptacle. The at least one conduit may be defined, at least in part, by the port assembly.

Abstract: A port assembly includes a valve housing with an inlet opening, a valve disposed in the valve housing to control access through the inlet opening, and a base having an outlet opening that is initially occluded by a membrane. A pivot is disposed within the base and has a cutting surface disposed within the base, the cutting surface rupturing the membrane at least in part as the pivot is pivoted about an axis between first and second positions. The port assembly may be used in a fluid container that includes a receptacle for retaining a fluid, and at least one conduit in communication with the receptacle. The at least one conduit is defined, at least in part, by the port assembly.

Abstract: A port assembly includes a valve housing with an inlet opening, a valve disposed in the valve housing to control access through the inlet opening, and a base joined to the valve housing and having a bore therethrough. The bore has a closed end defined by a frangible barrier, and a pushrod is disposed in the bore between the valve and the frangible barrier, axial movement of the pushrod causing rupture of the frangible barrier. The port assembly may be used in a fluid container that includes a receptacle for retaining a fluid, and at least one conduit in communication with the receptacle. The at least one conduit is defined, at least in part, by a port assembly.

Abstract: A flow control clamp having first and second legs disposed in a generally facing relationship. The clamp includes apertures receiving a flexible tube therethrough. The first and second legs include surfaces disposed to irreversibly secure the legs together in the closed position.

Abstract: A needleless access port is assembled from parts sealed to a flexible container, such as a container for intravenous infusion, parenteral nutrition or transfusion. The port includes a lower housing for sealing to the container, the lower housing having an upright tower for mounting an upper housing. The upper housing has at least one connector or valve and a sleeve for mounting to the tower. The sleeve includes connectors so the upper housing can be mounted in a first, upper resting position, and a second lower, active position, for adding liquid to the container or for removing liquid from the container. Even after assembly to a container, the upper housing may be removed and the lower housing may be used instead with a standard IV spike set.

Abstract: A flow control clamp (30) having first and second legs (36, 38) disposed in a generally facing relationahip. The clamp includes apertures (40, 44) for receiving a flexible tube therethrough. The first and second legs include surfaces disposed to irreversibly secure the legs together in the closed position.

Abstract: Needle protectors for retaining needles are disclosed. The needle protector includes a housing with an opening at each of a proximal and distal end. The needle protector may include a portion that is depressible to a substantially fixed position over the needle retracted within the housing.