Patents by Inventor Gianpaolo Negrisoli

Gianpaolo Negrisoli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide derivatives and therapeutic activity thereof
    Patent number: 11420943
    Abstract: Disclosed are peptide or pseudopeptide derivatives containing a nitrogenous heterocyclic residue with blocking activity against the by-products of lipid oxidative stress, and in particular of unsaturated aldehydes such as malondialdehyde and 4-hydroxy-trans-2-nonenal (HNE).
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: August 23, 2022
    Assignee: FLAMMA S.P.A.
    Inventors: GianPaolo Negrisoli, Stefania Gagliardi, Almin Silnovic, Clelia Dallanoce, Marco De Amici, Renato Canevotti
  • PEPTIDE DERIVATIVES AND THERAPEUTIC ACTIVITY THEREOF
    Publication number: 20200361875
    Abstract: Disclosed are peptide or pseudopeptide derivatives containing a nitrogenous heterocyclic residue with blocking activity against the by-products of lipid oxidative stress, and in particular of unsaturated aldehydes such as malondialdehyde and 4-hydroxy-trans-2-nonenal (HNE).
    Type: Application
    Filed: December 19, 2018
    Publication date: November 19, 2020
    Applicant: FLAMMA S.P.A.
    Inventors: GianPaolo NEGRISOLI, Stefania GAGLIARDI, Almin SILNOVIC, Clelia DALLANOCE, Marco DE AMICI, Renato CANEVOTTI
  • Peptide derivatives with therapeutic activity
    Patent number: 8765798
    Abstract: Dipeptide compounds containing a histidine residue proved to have interesting blocking activity on secondary products from lipid oxidative stress, in particular on unsaturated aldehydes such as malondialdehyde and hydroxynonenal, which are known to contribute to the inset of quite a number of chronic pathologies such as neurodegenerative, inflammatory chronic, cardiovascular diseases, diabetes complications and cataract.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: July 1, 2014
    Assignee: Flamma S.p.A.
    Inventors: Gianpaolo Negrisoli, Renato Canevotti
  • Amino alcohol derivatives and their therapeutic activities
    Patent number: 8623900
    Abstract: The present invention relates to amino alcohol derivatives of general formula I: These derivatives possess an interesting activity in that they block the secondary products of lipid oxidative stress, and are consequently suitable for therapeutic use in all disorders related with the presence of reactive carbonyl compounds.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: January 7, 2014
    Assignees: Flamma S.p.A., Universita degli Studi di Milano
    Inventors: Gianpaolo Negrisoli, Renato Canevotti, Massimo Previtali, Giancarlo Aldini, Marina Carini, Marica Orioli, Giulio Vistoli
  • AMINO ALCOHOL DERIVATIVES AND THEIR THERAPEUTIC ACTIVITIES
    Publication number: 20120316212
    Abstract: The present invention relates to amino alcohol derivatives of general formula I: These derivatives possess an interesting activity in that they block the secondary products of lipid oxidative stress, and are consequently suitable for therapeutic use in all disorders related with the presence of reactive carbonyl compounds.
    Type: Application
    Filed: December 20, 2010
    Publication date: December 13, 2012
    Applicants: UNIVERSITA DEGLI STUDI DI MILANO, FLAMMA S.P.A.
    Inventors: Gianpaolo Negrisoli, Renato Canevotti, Massimo Previtali, Giancarlo Aldini, Marina Carini, Marica Orioli, Giulio Vistoli
  • DIPEPTIDE COMPOUNDS CONTAINING D-HISTIDINE
    Publication number: 20090306165
    Abstract: D-Camosine lipophilic derivatives are disclosed, characterized by higher bioavailability than L-camosine and intended for the pulmonary distribution where they can exert detoxifying activity on the cytotoxic carbonyl compounds induced by cigarette smoke.
    Type: Application
    Filed: June 15, 2007
    Publication date: December 10, 2009
    Inventors: Gianpaolo Negrisoli, Renato Canevotti, massimo Previtali
  • PEPTIDE DERIVATIVES WITH THERAPEUTIC ACTIVITY
    Publication number: 20090247601
    Abstract: Dipeptide compounds containing a histidine residue proved to have interesting blocking activity on secondary products from lipid oxidative stress, in particular on unsaturated aldehydes such as malondialdehyde and hydroxynonenal, which are known to contribute to the inset of quite a number of chronic pathologies such as neurodegenerative, inflammatory chronic, cardiovascular diseases, diabetes complications and cataract.
    Type: Application
    Filed: June 15, 2007
    Publication date: October 1, 2009
    Inventors: Gianpaolo Negrisoli, Renato Canevotti
  • Compositions Containing D-Carnosine
    Publication number: 20080194493
    Abstract: Disclosed are compositions containing D-carnosine as active ingredient, mixed with suitable vehicles or excipients.
    Type: Application
    Filed: June 7, 2005
    Publication date: August 14, 2008
    Inventors: Giancarlo Aldini, Renato Canevotti, Gianpaolo Negrisoli
  • Hydrosoluble organic salts of creatine
    Patent number: 5973199
    Abstract: Hydrosoluble organic salts of creatine are disclosed. The salts are useful in the dietetic and food industry.
    Type: Grant
    Filed: May 22, 1996
    Date of Patent: October 26, 1999
    Assignee: Flamma S.p.A.
    Inventors: Gianpaolo Negrisoli, Lucno Del Corona