Patents by Inventor Gianpiero De Cillis

Gianpiero De Cillis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Barbituric acid derivatives with antimetastatic and antitumor activity
    Patent number: 6335332
    Abstract: The invention is directed to barbituric acid derivatives having inhibitory activity for matrix maetalloproteases comprised of formula (I): pharmaceutical compositions thereof, processes for preparing the derivatives, and methods for treating diseases associated with elevated or uncontrolled levels of matrix metalloprotease activity, e.g., cancer, specifically tumor progression and tumor metastasis, inflammation, or as a method of contraception.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: January 1, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Ambrogio Oliva, Gianpiero De Cillis, Frank Grams, Valeria Livi, Gerd Zimmermann, Ernesto Menta, Hans-Willi Krell
  • 2-alkylidene hydroxycumaranone derivatives
    Patent number: 6200989
    Abstract: Compounds of the formula wherein R,R′, A,B,T and x have the meaning given in the specification possess uPA (urokinase-type plasminogen activator) antagonist activity and can be employed as antitumor and/or antimetastatic agents.
    Type: Grant
    Filed: September 22, 1999
    Date of Patent: March 13, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gianpiero De Cillis, Roberto Di Domenico, Bernhard Könic, Ambrogio Oliva
  • Heterocyclic amines useful in the therapy of asthma and imflammation of the respiratory tract
    Patent number: 5453423
    Abstract: Compounds of the formula ##STR1## wherein A, Y, X, B and D are described in the specification are disclosed. The compounds possess activity in treating asthma and other pathologies of the respiratory tract.
    Type: Grant
    Filed: September 27, 1993
    Date of Patent: September 26, 1995
    Assignee: Boehringer Mannheim Italia S.p.A.
    Inventors: Giorgio Long, Carmelo A. Gandolfi, Gianpiero De Cillis, Roberto Di Domenico, Antonella Rozzi, Licia Gallico