Patents by Inventor Gideon Dreyfuss

Gideon Dreyfuss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7459309
    Abstract: The invention relates to an isolated nucleic acid encoding a eukaryotic Survival of Motor Neuron-Interacting Protein 1 (SIP1), compositions comprising SIP1 and SIP1 and the spinal muscular atrophy (SMA) disease gene product Survival of Motor Neuron protein (SMN), and diagnostic and therapeutic assays directed to SMA. The invention also relates to another protein that specifically interacts with SMN and is a component of gems, designated Gemin3, and the nucleic acid encoding the protein. Additionally, the invention relates to a novel cell line wherein the endogenous SMN genes have been deleted and where an exogenous nucleic acid encoding SMN has been inserted into the cell such that expression of SMN in the cell is under the control of an inducible promoter. This novel cell line provides a stable genetic system for the study of SMA and for the development of SMA therapeutics.
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: December 2, 2008
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Gideon Dreyfuss, Utz Fischer, Qing Liu, Bernard Charroux, Livio Pellizzoni
  • Publication number: 20080194027
    Abstract: The present invention includes methods for modulating the expression of a gene or mRNA in a cell using small nuclear RNAs comprising specific sequence and structural features and further comprising a nucleic acid cargo.
    Type: Application
    Filed: August 29, 2007
    Publication date: August 14, 2008
    Inventors: Gideon Dreyfuss, Jeongsik Yong, Tracey (Golembe) Polsky
  • Publication number: 20060223092
    Abstract: The present invention includes assays and kits for detecting the assembly of an RNA binding protein-RNA complex and for detecting the activity of an RNA binding protein.
    Type: Application
    Filed: March 10, 2006
    Publication date: October 5, 2006
    Inventors: Gideon Dreyfuss, Lili Wan, Elizabeth Ottinger
  • Publication number: 20060135509
    Abstract: The present invention provides methods for treating neurological diseases and disorders. Compounds that replace or enhance the function of SMN or alleviate or reduce a phenotype of cells with low SMN protein levels are provided. Screening methods and kits for identifying such compounds also are provided.
    Type: Application
    Filed: October 17, 2003
    Publication date: June 22, 2006
    Inventors: Gideon Dreyfuss, Jin Wang
  • Publication number: 20050100923
    Abstract: The invention relates to an isolated nucleic acid encoding a eukaryotic Survival of Motor Neuron-Interacting Protein 1 (SIP1), compositions comprising SIP1 and SIP1 and the spinal muscular atrophy (SMA) disease gene product Survival of Motor Neuron protein (SMN), and diagnostic and therapeutic assays directed to SMA. The invention also relates to another protein that specifically interacts with SMN and is a component of gems, designated Gemin3, and the nucleic acid encoding the protein. Additionally, the invention relates to a novel cell line wherein the endogenous SMN genes have been deleted and where an exogenous nucleic acid encoding SMN has been inserted into the cell such that expression of SMN in the cell is under the control of an inducible promoter. This novel cell line provides a stable genetic system for the study of SMA and for the development of SMA therapeutics.
    Type: Application
    Filed: October 2, 2003
    Publication date: May 12, 2005
    Inventors: Gideon Dreyfuss, Utz Fischer, Qing Liu, Bernard Charroux, Livio Pellizzoni
  • Patent number: 6646113
    Abstract: The invention relates to an isolated nucleic acid encoding a eukaryotic Survival of Motor Neuron-Interacting Protein 1 (SIP1), compositions comprising SIP1 and SIP1 and the spinal muscular atrophy (SMA) disease gene product Survival of Motor Neuron protein (SMN), and diagnostic and therapeutic assays directed to SMA. The invention also relates to another protein that specifically interacts with SMN and is a component of gems, designated Gemin3, and the nucleic acid encoding the protein. Additionally, the invention relates to a novel cell line wherein the endogenous SMN genes have been deleted and where an exogenous nucleic acid encoding SMN has been inserted into the cell such that expression of SMN in the cell is under the control of an inducible promoter. This novel cell line provides a stable genetic system for the study of SMA and for the development of SMA therapeutics.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: November 11, 2003
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Gideon Dreyfuss, Utz Fischer, Qing Liu, Bernard Charroux, Livio Pellizzoni
  • Publication number: 20010029025
    Abstract: The invention relates to a method of isolating an interacting protein.
    Type: Application
    Filed: February 12, 2001
    Publication date: October 11, 2001
    Inventor: Gideon Dreyfuss
  • Patent number: 5876949
    Abstract: The present invention relates to substantially pure FXR1 and FXR2 proteins and isolated nucleic acid molecules encoding the same. Recombinant expression vectors comprising nucleic acid sequences that encode FXR1 and FXR2 protein are also provided. Antibodies which bind to an epitope of FXR1 or FXR2, or FMR1 protein are also provided. The present invention also relates to methods of screening individuals for FMR1 deficiency using antibodies or nucleic acid molecules of the invention and pharmaceutical kits for accomplishing the same.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: March 2, 1999
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Gideon Dreyfuss, Mikiko C. Siomi, Yan Zhang
  • Patent number: 5457026
    Abstract: A method of promoting annealing of two nucleic acid molecules that contain complementary nucleotide sequences is disclosed. The method comprises the step of contacting the nucleic acid molecules in the presence of hnRNP U protein. A kit for hybridizing two nucleic acid molecules is disclosed. Isolated DNA molecules encoding the hnRNP U protein, expression vectors comprising the DNA molecule, host cells transformed with the expression vector and a method of producing essentially pure hnRNP U protein are disclosed. Essentially pure hnRNP U protein is disclosed. Methods of facilitating intermolecular interactions between two molecules in which at least one molecule is a nucleic acid by contacting the molecules in the presence of a protein, such as hnRNP U protein, which comprises a highly conserved "RGG box" amino acid sequence pattern are disclosed.
    Type: Grant
    Filed: November 20, 1992
    Date of Patent: October 10, 1995
    Assignee: University of Pennsylvania
    Inventors: Gideon Dreyfuss, Megerditch Kiledjian, Douglas S. Portman