Patents by Inventor Gideon Pilarski

Gideon Pilarski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID STATE FORMS OF SITAGLIPTIN SALTS
    Publication number: 20120316175
    Abstract: Solid state forms of Sitagliptin salts, processes for preparing the solid state forms, and pharmaceutical compositions thereof, are provided.
    Type: Application
    Filed: August 20, 2012
    Publication date: December 13, 2012
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: Gideon PILARSKI, Nurit PERLMAN, Ariel MITTELMAN, Nada KOSUTIC HULITA, Marina KALUJNY, Revital RAMATY
  • Solid state forms of sitagliptin salts
    Patent number: 8329696
    Abstract: Solid state forms of Sitagliptin salts (e.g. Sitagliptin sulfate, Formula I), processes for preparing the solid state forms, and pharmaceutical compositions thereof, are provided. These compounds are of a class of dipeptidyl peptidase IV enzyme inhibitors which are useful, for example, for the manufacture of a medicament for the treatment of type 2 diabetes mellitus.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: December 11, 2012
    Assignee: Teva Pharmaceuticals Industries Ltd.
    Inventors: Gideon Pilarski, Nurit Perlman, Ariel Mittelman, Nada Kosutic Hulita, Marina Kalujny, Revital Ramaty
  • SOLID STATE FORMS OF SITAGLIPTIN SALTS
    Publication number: 20100249140
    Abstract: Solid state forms of Sitagliptin salts, processes for preparing the solid state forms, and pharmaceutical compositions thereof, are provided.
    Type: Application
    Filed: March 29, 2010
    Publication date: September 30, 2010
    Applicant: Teva Pharmaceutical Industries Ltd.
    Inventors: Gideon PILARSKI, Nurit PERLMAN, Ariel MITTELMAN, Nada KOSUTIC HULITA, Marina KALUJNY, Revital RAMATY
  • Method for the preparation of Pregabalin and salts thereof
    Patent number: 7763749
    Abstract: Processes for preparing and purifying Pregabalin and salts thereof are provided.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: July 27, 2010
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Lilach Hedvati, Ziv Dee Noor, Claude Singer, Gideon Pilarski
  • Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
    Patent number: 7678938
    Abstract: The invention relates to pure (R)-CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)-CMH and to the process for isolating (S)-CMH from the mother liquor.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: March 16, 2010
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Lilach Hedvati, Ziv Dee-Noor, Claude Singer, Gideon Pilarski
  • NILOTINIB INTERMEDIATES AND PREPARATION THEREOF
    Publication number: 20100016590
    Abstract: Intermediates of Nilotinib were prepared, including, for example, 3-(trifluoromethyl-5-(4-methyl-1H-imidazole-1-yl)-benzeneamine; 3-(4-(pyridin-3-yl)pyrimidin-2-ylamino) -4-methylbenzoyl halogen dihydrochloride; and N-(3-Bromo-5-trifluoromethylphenyl)-4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide. Nilotinib.3HCl and its crystalline forms are also described.
    Type: Application
    Filed: July 17, 2009
    Publication date: January 21, 2010
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: Yanling WANG, Jie LI, Vinod Kumar KANSAL, Jirang ZHU, Revital LIFSHITZ-LIRON, Dhirenkumar N. MISTRY, Sanjay L. VASOYA, Sundaraselvan ARIYAMUTHU, Gideon PILARSKI, Xungui HE
  • Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
    Patent number: 7619112
    Abstract: The invention relates to pure (R)—CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)—CMH and to the process for isolating (S)—CMH from the mother liquor.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: November 17, 2009
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Lilach Hedvati, Ziv Dee-Noor, Claude Singer, Gideon Pilarski
  • Olmesartan medoxomil with reduced levels of impurities
    Publication number: 20090209603
    Abstract: The present invention provides the preparation of olmesartan medoxomil containing less than about 0.1% of one or more of the impurities OLM-Me, OLM-Cl, and OLM-eliminate.
    Type: Application
    Filed: February 19, 2009
    Publication date: August 20, 2009
    Inventors: Lilach Hedvati, Gideon Pilarski
  • Synthesis of gatifloxacin
    Patent number: 7531656
    Abstract: Provided are a method for making (±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolenecarboxylic acid, commonly known as gatifloxacin, in high purity, in a suspension in a dipolar aprotic solvent.
    Type: Grant
    Filed: August 14, 2003
    Date of Patent: May 12, 2009
    Assignee: Teva Pharmaceuticals USA, Inc.
    Inventors: Valerie Niddam-Hildesheim, Ben-Zion Dolitzky, Gideon Pilarski, Greta Sterimbaum
  • Processes for solifenacin preparation
    Publication number: 20090099365
    Abstract: Processes for preparing solifenacin comprising distilling ethanol and organic solvent from a reaction mixture and recycling the organic solvent are described. Also described are processes for reducing solifenacin diastereomeric and enantiomeric impurities.
    Type: Application
    Filed: July 14, 2008
    Publication date: April 16, 2009
    Inventors: Nurit Perlman, Gideon Pilarski
  • Pregabalin free of lactam and a process for preparation thereof
    Patent number: 7488846
    Abstract: The present invention encompasses Pregabalin substantially free of Lactam and a process for obtaining Pregabalin substantially free of Lactam comprising extracting an acidic mixture containing a complex of Pregabalin with a strong mineral acid, with C3-8 alcohol; and combining the organic phase with an organic base.
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: February 10, 2009
    Assignee: Teva Pharmaceuical Industries Ltd.
    Inventors: Lilach Hedvati, Gideon Pilarski, Yuriy Raizi, Sharon Tomer, Ziv Dee-Noor, Claude Singer
  • Pregabalin free of isobutylglutaric acid and a process for preparation thereof
    Patent number: 7462737
    Abstract: A Pregabalin having a low level of 3-isobutylglutaric acid is provided.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: December 9, 2008
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Lilach Hedvati, Ziv Dee-Noor, Claude Singer, Gideon Pilarski, Yuriy Raizi, Sharon Tomer
  • Novel synthesis of gatifloxacin
    Publication number: 20080188658
    Abstract: Provided is a method for making (±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolenecarboxylic acid, commonly known as gatifloxacin, in high purity, in a suspension in a dipolar aprotic solvent.
    Type: Application
    Filed: April 2, 2008
    Publication date: August 7, 2008
    Inventors: Valerie Niddam-Hildesheim, Ben-Zion Dolitzky, Gideon Pilarski, Greta Sterimbaum
  • Processes for preparing substantially pure pantoprazole magnesium
    Publication number: 20080177076
    Abstract: Provided are processes for preparing substantially pure pantoprazole magnesium.
    Type: Application
    Filed: November 5, 2007
    Publication date: July 24, 2008
    Inventors: Lilach Hedvanti, Gideon Pilarski
  • Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
    Publication number: 20070287859
    Abstract: The invention relates to pure (R)-CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)-CMH and to the process for isolating (S)-CMH from the mother liquor.
    Type: Application
    Filed: August 14, 2007
    Publication date: December 13, 2007
    Inventors: Lilach Hedvati, Dee-Noor Ziv, Claude Singer, Gideon Pilarski
  • Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
    Publication number: 20070287860
    Abstract: The invention relates to pure (R)—CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)—CMH and to the process for isolating (S)—CMH from the mother liquor.
    Type: Application
    Filed: August 14, 2007
    Publication date: December 13, 2007
    Inventors: Lilach Hedvati, Ziv Dee-Noor, Claude Singer, Gideon Pilarski
  • Optical resolution of-3-carbamoylmethyl-5-methyl hexanoic acid
    Publication number: 20070287748
    Abstract: The invention relates to pure (R)—CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)—CMH and to the process for isolating (S)—CMH from the mother liquor.
    Type: Application
    Filed: August 14, 2007
    Publication date: December 13, 2007
    Inventors: Lilach Hedvati, Ziv Dee-Noor, Claude Singer, Gideon Pilarski
  • Method for the preparation of pregabalin and salts thereof
    Publication number: 20070073085
    Abstract: Processes for preparing and purifying Pregabalin and salts thereof are provided.
    Type: Application
    Filed: May 10, 2006
    Publication date: March 29, 2007
    Inventors: Lilach Hedvati, Ziv Dee Noor, Claude Singer, Gideon Pilarski
  • Novel synthesis of gatifloxacin
    Publication number: 20070072868
    Abstract: Provided are a method for making (±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolenecarboxylic acid, commonly known as gatifloxacin, in high purity, in a suspension in a dipolar aprotic solvent.
    Type: Application
    Filed: November 28, 2006
    Publication date: March 29, 2007
    Inventors: Valerie Niddam-Hildesheim, Ben-Zion Dolitzky, Gideon Pilarski, Greta Sterimbaum
  • Optical resolution of 3-carbamoylmethyl-5-methylhexanoic acid
    Publication number: 20070043241
    Abstract: The invention relates to pure (R)—CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)—CMH and to the process for isolating (S)—CMH from the mother liquor.
    Type: Application
    Filed: May 10, 2006
    Publication date: February 22, 2007
    Inventors: Lilach Hedvati, Ziv Dee-Noor, Claude Singer, Gideon Pilarski