Patents by Inventor Giedre KRENCIUTE

Giedre KRENCIUTE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF GENERATING AN ACTIVATION INDUCIBLE EXPRESSION SYSTEM IN IMMUNE CELLS
    Publication number: 20230340067
    Abstract: The present invention provides methods of genetically modifying an immune cell such that the immune cell expresses a transgene in an activation dependent manner. The application also provides genetically modified immune cells prepared using such methods, and the uses of the genetically modified immune cells in immunotherapy (e.g., adoptive cell therapy) for treatment of a disease such as cancer, autoimmune disease or infectious disease.
    Type: Application
    Filed: June 25, 2021
    Publication date: October 26, 2023
    Applicant: St. Jude Children's Research Hospital, Inc.
    Inventors: Stephen GOTTSCHALK, Giedre KRENCIUTE, Zelda ODE
  • T CELL GENE EXPRESSION ANALYSIS FOR USE IN T CELL THERAPIES
    Publication number: 20220326216
    Abstract: The application provides T cell gene expression signatures that can be used to predict T cell therapy outcomes.
    Type: Application
    Filed: April 8, 2020
    Publication date: October 13, 2022
    Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
    Inventors: Benjamin YOUNGBLOOD, Jeremy CRAWFORD, Yiping FAN, Caitlin ZEBLEY, Stephen GOTTSCHALK, Giedre KRENCIUTE, Christopher PETERSEN
  • DNMT3A KNOCK-OUT STAT5 ACTIVATED GENETICALLY ENGINEERED T-CELLS
    Publication number: 20220226379
    Abstract: The application provides modified immune effector cells wherein the DNA (cytosine-5)-methyltransferase 3A (DNMT3A)-mediated de novo DNA methylation of the cell genome is inhibited, and STAT5 signaling pathway is activated. The application also provides related pharmaceutical compositions and the methods for generating such modified immune effector cells. The application further provides uses of such modified immune effector cells for treating diseases such as cancers, infectious diseases and autoimmune diseases.
    Type: Application
    Filed: April 8, 2020
    Publication date: July 21, 2022
    Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
    Inventors: Stephen GOTTSCHALK, Giedre KRENCIUTE, Christopher PETERSEN, Benjamin YOUNGBLOOD
  • CHIMERIC ANTIGEN RECEPTORS WITH CD20 SAFETY SWITCH
    Publication number: 20220195007
    Abstract: The present disclosure provides chimeric antigen receptors (CARs), particularly CARs that have enhanced antitumor properties and/or can be regulated by safety switches. Also provided are polypeptides of the CARs and other related molecules, polynucleotides, vectors, and cell compositions comprising the same. Pharmaceutical compositions comprising the polypeptides, polynucleotides, vectors, or cells of the present disclosure, and their uses in treating a cancer in a subject are also provided.
    Type: Application
    Filed: April 10, 2020
    Publication date: June 23, 2022
    Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
    Inventors: Mireya Paulina VELASQUEZ, Stephen GOTTSCHALK, Janice RIBERDY, Albert ZHOU, Byoung RYU, Abishek VAIDYA, Giedre KRENCIUTE
  • CHIMERIC ANTIGEN RECEPTORS WITH MYD88 AND CD40 COSTIMULATORY DOMAINS
    Publication number: 20210252058
    Abstract: The application relates to a chimeric antigen receptor that targets Eph receptors and allows activation of co-stimulatory pathways. The application also relates to polynucleotides that encode the chimeric antigen receptor, vectors, and host cells comprising the chimeric antigen receptor. The application also relates to methods for preparing host cells comprising a chimeric antigen receptor in order to improve the in vivo effector function of the chimeric antigen receptor host cells.
    Type: Application
    Filed: May 17, 2019
    Publication date: August 19, 2021
    Applicants: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC., BAYLOR COLLEGE OF MEDICINE
    Inventors: Stephen GOTTSCHALK, Brooke PRINZING, Giedre KRENCIUTE