Patents by Inventor Gifford P. Marzoni

Gifford P. Marzoni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiproliferative compounds having nitrogen-containing tricyclic ring systems and phenyl substituents
    Patent number: 5574039
    Abstract: The invention relates to TS-inhibiting compounds of the formula ##STR1## where W is an alkylene group; D is a structure having two rings that are unsubstituted or substituted, where (i) one ring is a phenyl ring and (ii) the other ring is a phenyl ring or a 6-membered heterocyclic ring; R is a hydrogen atom or an alkyl group; and X and Y together form ##STR2## and to salts of these compounds. The moiety W can be CH.sub.2, and D can be a phenyl ring bridged through a sulfonyl group to another ring.
    Type: Grant
    Filed: September 22, 1994
    Date of Patent: November 12, 1996
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Michael D. Varney, Gifford P. Marzoni, Cynthia L. Palmer, Judith P. Deal, Terence R. Jones
  • Process of making alkoxy cycloalkanol esters of dihydrolysergic acid
    Patent number: 4968802
    Abstract: Alkoxycycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.
    Type: Grant
    Filed: January 10, 1990
    Date of Patent: November 6, 1990
    Assignee: Eli Lilly and Company
    Inventors: William L. Garbrecht, Gifford P. Marzoni, Kathleen R. Whitten
  • Cycloalkanol esters of dihydrolysergic acid
    Patent number: 4939258
    Abstract: Cycloalkyl or ketocycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)-ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.
    Type: Grant
    Filed: January 10, 1990
    Date of Patent: July 3, 1990
    Assignee: Eli Lilly and Company
    Inventors: Kathleen R. Whitten, William L. Garbrecht, Gifford P. Marzoni, C. John Parli
  • Cycloalkylamides of (8.beta.)-1-alkyl-6-(substituted) ergolines
    Patent number: 4931447
    Abstract: This invention provides (8.beta.)-N-cycloalkyl-1-alkyl-6-(substituted) ergoline-8-carboxamides useful for blocking 5HT.sub.2 receptors in mammals having an excess of serotonin centrally or peripherally. The invention also provides methods for treating hypertension, migraine, vasospasm, thrombosis, ischemia, depression, anxiety, sleep disorders and appetite disorders with a compound of the invention.
    Type: Grant
    Filed: August 14, 1989
    Date of Patent: June 5, 1990
    Assignee: Eli Lilly and Company
    Inventors: Mark M. Foreman, William L. Garbrecht, Gifford P. Marzoni, Kathleen R. Whitten
  • Alkoxy cycloalkanol esters of dihydrolysergic acid
    Patent number: 4914100
    Abstract: Alkoxycycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.
    Type: Grant
    Filed: April 24, 1989
    Date of Patent: April 3, 1990
    Assignee: Eli Lilly and Company
    Inventors: William L. Garbrecht, Gifford P. Marzoni, Kathleen R. Whitten
  • Cycloalkanol esters of dihydrolysergic acid
    Patent number: 4906639
    Abstract: Cycloalkyl or ketocycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)-ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.
    Type: Grant
    Filed: April 11, 1989
    Date of Patent: March 6, 1990
    Assignee: Eli Lilly and Company
    Inventors: Kathleen R. Whitten, William L. Garbrecht, Gifford P. Marzoni, C. John Parli
  • Alkoxy cycloalkanol esters of dihydrolysergic acid having peripheral serotonin antagonists properties
    Patent number: 4847261
    Abstract: Alkoxycycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.
    Type: Grant
    Filed: September 29, 1988
    Date of Patent: July 11, 1989
    Assignee: Eli Lilly and Company
    Inventors: William L. Garbrecht, Gifford P. Marzoni, Kathleen R. Whitten
  • Cycloalkanol esters of dihydrolysergic acid having peripheral serotonin antagonist properties
    Patent number: 4845224
    Abstract: Cycloalkyl or ketocycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)-ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.
    Type: Grant
    Filed: April 29, 1987
    Date of Patent: July 4, 1989
    Assignee: Eli Lilly and Company
    Inventors: Kathleen R. Whitten, William L. Garbrecht, Gifford P. Marzoni, C. John Parli
  • Ergoline esters useful as serotonin antagonists
    Patent number: 4835159
    Abstract: The present invention provides novel bicyclic ergoline esters useful as serotonin antagonists.
    Type: Grant
    Filed: August 24, 1988
    Date of Patent: May 30, 1989
    Assignee: Eli Lilly and Company
    Inventors: William L. Garbrecht, Gifford P. Marzoni, Pawel Fludzinski
  • Ketoalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists
    Patent number: 4820713
    Abstract: Ketoalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acid, useful as 5HT receptor antagonists.
    Type: Grant
    Filed: May 23, 1988
    Date of Patent: April 11, 1989
    Assignee: Eli Lilly and Company
    Inventors: Gifford P. Marzoni, William L. Garbrecht
  • Ergoline esters useful as serotonin antagonists
    Patent number: 4782063
    Abstract: The present invention provides novel bicyclic ergoline esters useful as serotonin antagonists.
    Type: Grant
    Filed: May 11, 1987
    Date of Patent: November 1, 1988
    Assignee: Eli Lilly and Company
    Inventors: William L. Garbrecht, Gifford P. Marzoni, Pawel Fludzinski
  • Process of making ketoalkanol esters of dihydrolysergic acid
    Patent number: 4772709
    Abstract: Ketoalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acid, useful and 5HT receptor antagonists.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: September 20, 1988
    Assignee: Eli Lilly and Company
    Inventors: Gifford P. Marzoni, William L. Garbrecht
  • N-alkylation of dihydrolysergic acid
    Patent number: 4734501
    Abstract: The present invention provides a process for N-alkylating dihydrolysergic acid with a substituted benzenesulfonate derivative.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: March 29, 1988
    Assignee: Eli Lilly and Company
    Inventor: Gifford P. Marzoni
  • Alkoxy cycloalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists
    Patent number: 4714704
    Abstract: Alkoxycycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: December 22, 1987
    Assignee: Eli Lilly and Company
    Inventors: William L. Garbrecht, Gifford P. Marzoni, Kathleen R. Whitten
  • Alkoxy and dialkoxyalkyl esters of dihydrolysergic acid and related compounds useful as 5HT receptor antagonists
    Patent number: 4713385
    Abstract: Alkoxy or dialkoxyalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acid, useful as 5HT receptor antagonists.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: December 15, 1987
    Assignee: Eli Lilly and Company
    Inventors: Gifford P. Marzoni, William L. Garbrecht
  • Cyclic ether esters of 2-substituted-6-(substituted and unsubstituted) dihydrolysergic acid useful as 5HT receptor antagonists
    Patent number: 4704395
    Abstract: Cyclic ether esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acid, useful as 5HT receptor antagonists.
    Type: Grant
    Filed: December 20, 1985
    Date of Patent: November 3, 1987
    Assignee: Eli Lilly and Company
    Inventors: Gifford P. Marzoni, William L. Garbrecht
  • Fluoroalkyl esters of dihydrolysergic acid useful as 5HT.sub.2 receptor antagonists
    Patent number: 4683237
    Abstract: Mono, difluoro or trifluoroalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)-ergoline-8.beta.-carboxylic acid, useful as 5HT.sub.2 receptor antagonists.
    Type: Grant
    Filed: December 20, 1985
    Date of Patent: July 28, 1987
    Assignee: Eli Lilly and Company
    Inventors: Gifford P. Marzoni, William L. Garbrecht
  • Cycloalkanol esters of dihydrolysergic acid useful as 5Ht.sub.2 receptor antagonists
    Patent number: 4683236
    Abstract: Cycloalkyl or ketocycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)-ergoline-8.beta.-carboxylic acids, useful as 5HT.sub.2 receptor antagonists.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: July 28, 1987
    Assignee: Eli Lilly and Company
    Inventors: Kathleen R. Whitten, William L. Garbrecht, Gifford P. Marzoni, C. John Parli
  • Synthesis of thiazoles
    Patent number: 4468517
    Abstract: Certain 4-halomethylthiazoles having a 2-substituted-aminomethyl group are prepared by reacting an aminothioamide with a dihalopropanone in the presence of a haloalkane and a bicarbonate, and dehydrating the resulting intermediate.
    Type: Grant
    Filed: May 12, 1983
    Date of Patent: August 28, 1984
    Assignee: Eli Lilly and Company
    Inventor: Gifford P. Marzoni