Patents by Inventor Gigi Ngar Chee CHIU

Gigi Ngar Chee CHIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED AZOLE DERIVATIVES FOR GENERATION, PROLIFERATION AND DIFFERENTIATION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS
    Publication number: 20190359941
    Abstract: The present invention relates to substituted azole derivatives in combination with cytokines in the ex vivo expansion of CD34+ hematopoietic stem and progenitor cells (HSPC) in a biological sample, more particularly the expansion of these cells obtained from non-enriched, i.e., the mononuclear fraction of the biological sample. The present invention further describes the transplantation regimen of the expanded hematopoietic graft developed through xenotransplantation studies. In a preferred embodiment, the combination comprising the azole based compounds and cytokines selected from SCF, TPO, FLT-3L and IGFBP-2 and results in the expansion of expansion of CD45+CD34+CD38?CD45RA?CD90+ hematopoietic stem cells and/or CD45+CD34+CD38?CD45RA?CD90+CD49f+ hematopoietic stem cells and/or CD45+CD34+CD38?CD45RA? hematopoietic progenitor cells from the mononucleated cells isolated from umbilical cord blood.
    Type: Application
    Filed: August 18, 2017
    Publication date: November 28, 2019
    Applicants: National University of Singapore, Singapore Health Services Pte Ltd
    Inventors: Sudipto BARI, Christina Li Lin CHAI, Gigi Ngar Chee CHIU, William Ying Khee HWANG, Joo Leng LOW, Qixing ZHONG