Patents by Inventor Gihan M. Hashem

Gihan M. Hashem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conversion of a watson-crick DNA to a hoogsteen-paired duplex
    Patent number: 6362322
    Abstract: A method is described for obtaining Hoogsteen-paired pyrimidine*purine duplexes, either by heating a triplex to dissociate a Watson-Crick paired pyrimidine strand or by linking two parallel strands at their 5′ ends is disclosed. This duplex can be used as a new type of antisense molecule to pair with an RNA pyrimidine target sequence within an mRNA molecule. This duplex can also be used as a new type of antigene molecule to pair with a single-stranded DNA pyrimidine target sequence within the genome.
    Type: Grant
    Filed: January 19, 2000
    Date of Patent: March 26, 2002
    Assignee: Board of Regents, The University of Texas System
    Inventors: Donald M. Gray, Gihan M. Hashem