Patents by Inventor Gijsbertus Theodorus Johannes van der Horst

Gijsbertus Theodorus Johannes van der Horst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PREMATURELY AGEING MOUSE MODELS FOR THE ROLE OF DNA DAMAGE IN AGEING AND INTERVENTION IN AGEING-RELATED PATHOLOGY
    Publication number: 20090077676
    Abstract: The current invention pertains to a method for screening and discovery of compounds capable of inhibiting, preventing, delaying or reducing genome maintenance disorders and consequences thereof, in particular ageing related symptoms and disorders. The current invention provides a method for screening and discovery of compounds that are capable of inhibiting, preventing, delaying or reducing genome maintenance disorders and consequences thereof. The invention exploits animal models that comprise deficiencies in their genome maintenance systems, such as DNA repair systems, and display premature, enhanced, accelerated or segmental ageing phenotypes. These animal models can be advantageously applied to screen compounds and thereby develop schemes of intervention to treat, delay, inhibit, prevent or cure ageing related symptoms. The current invention thus provides a new and powerful tool to screen aid/or discover therapeutically active compounds to treat ageing related symptoms and diseases.
    Type: Application
    Filed: November 15, 2005
    Publication date: March 19, 2009
    Inventors: Jan Hendrik Jozef Hoeijmakers, Gijsbertus Theodorus Johannes van der Horst, Wim Vermeulen, Roland Kanaar, Ingrid van der Pluijm, George Aris Garinis, Harmen van Steeg, James Robbert Mitchell, Nicolaas Gerardus Josepth Jaspers, Laura Niedernhofer, Jan de Boer, Jaan Olle Andressoo