Patents by Inventor Gil H. Choi
Gil H. Choi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030049648Abstract: The present invention relates to novel genes from S. aureus and the polypeptides they encode. Also provided as are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of S. aureus polypeptide activity. The invention additionally relates to diagnostic methods for detecting Staphylococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Staphylococcus.Type: ApplicationFiled: February 28, 2002Publication date: March 13, 2003Inventor: Gil H. Choi
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Patent number: 6521441Abstract: The present invention relates to 11 novel genes from S. aureus and the polypeptides they encode. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of S. aureus polypeptide activity. The invention additionally relates to diagnostic methods for detecting Staphylococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Staphylococcus.Type: GrantFiled: January 15, 2002Date of Patent: February 18, 2003Assignees: Human Genome Sciences, Inc., Ludwig Institute For Cancer ResearchInventors: Andrew J. G. Simpson, Gil H. Choi
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Publication number: 20030017495Abstract: The present invention relates to novel genes from E. faecalis and the polypeptides they encode. Also provided as are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of E. faecalis polypeptide activity. The invention additionally relates to diagnostic methods for detecting Enterococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.Type: ApplicationFiled: July 29, 2002Publication date: January 23, 2003Applicant: Human Genome Sciences, Inc.Inventors: Gil H. Choi, Camella Bailey, Alex Hromockyj, Charles A. Kunsch
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Publication number: 20020164692Abstract: The present invention relates to novel human immune system-related polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human immune system-related polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human immune system-related polypeptides.Type: ApplicationFiled: September 12, 2001Publication date: November 7, 2002Inventors: Jian Ni, David Hilbert, Joseph J. Kenny, Paul A. Moore, Gil H. Choi, Daniel R. Soppet, Reinhard Ebner, Joachim R. Gruber, Gregory A. Endress, Steven M. Ruben
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Publication number: 20020146738Abstract: The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.Type: ApplicationFiled: April 5, 2002Publication date: October 10, 2002Applicant: Human Genome Sciences, Inc.Inventors: Antonio Jose C. Abad, Gil H. Choi, Richard A. Calderone
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Patent number: 6448043Abstract: The present invention relates to a novel gene from E. faecalis, EF040, and the encoded polypeptides. Also provided are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of E. faecalis EF040 polypeptide activity. The invention additionally relates to diagnostic methods for detecting Enterococcus EF040 nucleic acids, encoded polypeptides and anti-EF040 antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.Type: GrantFiled: May 4, 1998Date of Patent: September 10, 2002Assignee: Human Genome Sciences, Inc.Inventors: Gil H. Choi, Camella Bailey, Alex Hromockyj, Charles A. Kunsch
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Publication number: 20020120103Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: July 27, 2001Publication date: August 29, 2002Inventors: Craig A. Rosen, George A. Komatsoulis, Kevin P. Baker, Charles E. Birse, Daniel R. Soppet, Henrik S. Olsen, Paul A. Moore, Ping Wei, Reinhard Ebner, D. Roxanne Duan, Yanggu Shi, Gil H. Choi, Michele Fiscella, Jian Ni, Steven M. Ruben, Steven C. Barash
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Publication number: 20020110562Abstract: The present invention relates to novel immunogenic polypeptides, and fragments thereof, and vaccines for the prevention and treatment of pneumococcal infection, especially by Streptococcus pneumoniae. The invention also relates to antibodies against the disclosed polypeptides, as well as vaccines containing said polypeptides and methods of disease prevention.Type: ApplicationFiled: February 5, 2002Publication date: August 15, 2002Inventors: John E. Adamou, Gil H. Choi
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Publication number: 20020103338Abstract: The present invention relates to novel genes from S. aureus and the polypeptides they encode. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of S. aureus polypeptide activity. The invention additionally relates to diagnostic methods for detecting Staphylococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Staphylococcus.Type: ApplicationFiled: August 10, 2001Publication date: August 1, 2002Inventor: Gil H. Choi
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Patent number: 6420135Abstract: The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.Type: GrantFiled: October 30, 1997Date of Patent: July 16, 2002Assignee: Human Genome Sciences, Inc.Inventors: Charles A. Kunsch, Gil H. Choi, Patrick S. Dillon, Craig A. Rosen, Steven C. Barash, Michael R. Fannon, Brian A. Dougherty
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Patent number: 6416989Abstract: The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.Type: GrantFiled: October 15, 1999Date of Patent: July 9, 2002Assignees: Human Genome Sciences, Inc., The Georgetown UniversityInventors: Antonio Jose C. Abad, Gil H. Choi, Richard A. Calderone
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Publication number: 20020072595Abstract: The present invention relates to novel genes located in two chromosomal regions within uropathogenic E. coli that are associated with virulence. These chromosomal regions are known as pathogenicity islands (PAIs). In particular, the present application discloses 142 sequenced fragments (contigs) of DNA from two pools of cosmids covering pathogenicity islands PAI IV and PAI V located on the chromosome of the uropathogenic Escherichia coli J96. Further disclosed are 351 predicted protein-coding open reading frames within the sequenced fragments.Type: ApplicationFiled: September 20, 2001Publication date: June 13, 2002Applicant: Human Genome Sciences, Inc.Inventors: Patrick J. Dillon, Gil H. Choi, Rodney A. Welch
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Patent number: 6403337Abstract: The present invention relates to novel genes from S. aureus and the polypeptides they encode. Also provided as are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of S. aureus polypeptide activity. The invention additionally relates to diagnostic methods for detecting Staphylococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Staphylococcus.Type: GrantFiled: February 24, 2000Date of Patent: June 11, 2002Assignee: Human Genome Sciences, Inc.Inventors: Camella Bailey, Gil H. Choi
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Publication number: 20020061545Abstract: The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.Type: ApplicationFiled: January 22, 2001Publication date: May 23, 2002Inventors: Gil H. Choi, Charles A. Kunsch, Steven C. Barash, Patrick J. Dillon, Brian Dougherty, Michael R. Fannon, Craig A. Rosen
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Publication number: 20020045737Abstract: The present invention relates to novel genes from E. faecalis and the polypeptides they encode. Also provided as are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of E. faecalis polypeptide activity. The invention additionally relates to diagnostic methods for detecting Enterococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.Type: ApplicationFiled: May 4, 1998Publication date: April 18, 2002Applicant: HUMAN GENOME SCIENCES, INC.Inventors: GIL H. CHOI, CAMELLA BAILEY, ALEX HROMOCKYJ, CHARLES A. KUNSCH
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Publication number: 20020032323Abstract: The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.Type: ApplicationFiled: October 30, 1997Publication date: March 14, 2002Inventors: CHARLES A. KUNSCH, GIL H. CHOI, PATRICK J. DILLON, CRAIG A. ROSEN, STEVEN C. BARASH, MICHAEL R. FANNON, BRIAN A. DOUGHERTY
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Patent number: 6316609Abstract: The present invention relates to novel genes located in two chromosomal regions within uropathogenic E. coli that are associated with virulence. These chromosomal regions are known as pathogenicity islands (PAIs). In particular, the present application discloses 142 sequenced fragments (contigs) of DNA from two pools of cosmids covering pathogenicity islands PAI IV and PAI V located on the chromosome of the uropathogenic Escherichia coli J96. Further disclosed are 351 predicted protein-coding open reading frames within the sequenced fragments.Type: GrantFiled: November 21, 1997Date of Patent: November 13, 2001Assignees: Human Genome Sciences, Inc., Wisconsin Alumni Research FoundationInventors: Patrick J. Dillon, Gil H. Choi, Rodney A. Welch
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Patent number: 6159469Abstract: The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.Type: GrantFiled: October 30, 1997Date of Patent: December 12, 2000Assignee: Human Genome Sciences, Inc.Inventors: Gil H. Choi, Charles A. Kunsch, Steven C. Barash, Patrick J. Dillon, Brian Dougherty, Michael R. Fannon, Craig A. Rosen
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Patent number: 6120999Abstract: The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.Type: GrantFiled: July 9, 1998Date of Patent: September 19, 2000Assignees: Human Genome Sciences, Inc., The Georgetown UniversityInventors: Antonio Jose C. Abad, Gil H. Choi, Richard A. Calderone