Patents by Inventor Gil Koehane

Gil Koehane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydrolysis-promoting hydrophobic taxane derivatives
    Patent number: 6482850
    Abstract: Provided herein is a taxane having a hydrocarbon attached at the 2′ and/or 7 positions, the hydrocarbon's alpha position being occupied by a “hydrolysis-promoting group” (“HPG”). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the &agr;-carbon of the hydrophobic taxane. The Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers or inflammatory diseases.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: November 19, 2002
    Assignee: The Liposome Company
    Inventors: Shaukat Ali, J. Craig Franklin, Imran Ahmad, Eric Mayhew, Soumendu Bhattacharya, Gil Koehane, Andrew S. Janoff
  • Hydrolysis-promoting hydrophobic taxane derivatives
    Patent number: 6392063
    Abstract: Provided herein is a taxane having a hydrocarbon attached at the 2′ and/or 7 positions, the hydrocarbon's alpha position being occupied by a “hydrolysis-promoting group” (“HPG”). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the a-carbon of the hydrophobic taxane. The Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers or inflammatory diseases.
    Type: Grant
    Filed: July 19, 2000
    Date of Patent: May 21, 2002
    Assignee: The Liposome Company, Inc.
    Inventors: Shaukat Ali, J. Craig Franklin, Imran Ahmad, Eric Mayhew, Soumendu Bhattacharya, Gil Koehane, Andrew S. Janoff
  • Hydrolysis-promoting hydrophobic taxane derivatives
    Publication number: 20020052518
    Abstract: Provided herein is a taxane having a hydrocarbon attached at the 2′ and/or 7 positions, the hydrocarbon's alpha position being occupied by a “hydrolysis-promoting group” (“HPG”). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the &agr;-carbon of the hydrophobic taxane. The Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers or inflammatory diseases.
    Type: Application
    Filed: August 29, 2001
    Publication date: May 2, 2002
    Inventors: Shaukat Ali, J. Craig Franklin, Imran Ahmad, Eric Mayhew, Soumendu Bhattacharya, Gil Koehane, Andrew S. Janoff
  • Hydrolysis-promoting hydrophobic taxane derivatives
    Patent number: 6107332
    Abstract: Provided herein is a taxane having a hydrocarbon attached at the 2' and/or 7 positions, the hydrocarbon's alpha position being occupied by a "hydrolysis-promoting group" ("HPG"). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the .alpha.-carbon of the hydrophobic taxane. The Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers or inflammatory diseases.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: August 22, 2000
    Assignee: The Liposome Company, Inc.
    Inventors: Shaukat Ali, J. Craig Franklin, Imran Ahmad, Eric Mayhew, Soumendu Bhattacharya, Gil Koehane, Andrew S. Janoff