Abstract: An integrated system for automatic, accurate controlled and monitored online pill dispensing. The system has a vacuum based dispensing mechanism capable of individually select any number of pills from any of the programmable drug containers and prepares the required dosage in an easy to reach compartment. The pills are stored in the smart pill box filled by either the pharmacy according to doctor's prescriptions or by the patient with Over The Counter (OTC) pills. The system automatically detects the content of each smart pill box and its prescribed daily dosage to eliminate human errors. The system provides online information to the patient's Health Insurance Provider such as Drug Consuming Compliance, necessary data for drug interactions predictions and refill requests directly to the pharmacy in accordance with the health insurance provider policy.