Abstract: Disclosed is a hand-held sanitary device and to an impermeable and essentially biodegradable personal-hygiene sachet which can be filled with water and used for washing intimate body parts by gentle rubbing. The sanitary device chiefly includes a stop piece, a ring, a spring for keeping the personal-hygiene sachet sealed, a valve and connection to a water heater and dryer which is controlled by the valve. It can be used with running-water toilet bowls, without the need to use toilet paper. The sanitary device is particularly intended for the surface washing of intimate body parts, for vaginal washing, re-establishing pelvic-floor muscle tone, and pleasurable vaginal stimulation in women, using the hygienic sachet intended for each use.

Abstract: Disclosed is a hand-held sanitary device and to an impermeable and essentially biodegradable personal-hygiene sachet which can be filled with water and used for washing intimate body parts by gentle rubbing. The sanitary device chiefly includes a stop piece, a ring, a spring for keeping the personal-hygiene sachet sealed, a valve and connection to a water heater and dryer which is controlled by the valve. It can be used with running-water toilet bowls, without the need to use toilet paper. The sanitary device is particularly intended for the surface washing of intimate body parts, for vaginal washing, re-establishing pelvic-floor muscle tone, and pleasurable vaginal stimulation in women, using the hygienic sachet intended for each use.

Abstract: Described herein are methods and pharmaceutical compositions for the prevention and/or treatment of visual impairment and vision loss, and more particularly to the use of DAN family BMP antagonist(s) for the prevention of ocular neovascularization and, as a trophic factor for photoreceptors in eye diseases. Also described is a method for long-term inhibition of neovascularization in an ocular condition, a method of replacement therapy for vascular endothelial growth factor (VEGF) inhibitor treatment and a method for inhibiting and/or preventing ocular neovascularization and/or ocular angiogenesis in a mammalian subject, the methods comprising administering to a mammalian subject in need an effective amount a DAN family BMP antagonist such as DAND5.

Abstract: The invention is concerned with dementia-related neurological diseases and more particularly Alzheimer's disease. Herein described are primate cortical neuronal cells that are BMI1 -deficient and that displays one or more phenotypic hallmark of Alzheimer's disease. Also described are cellular models comprising such cells, methods for screening, designing anti-Alzheimer drugs and/or for identifying a potential biological target of an anti-Alzheimer drug using such cells. Described also are methods for diagnosing Alzheimer's disease, comprising assessing BMI1 activity and/or comprising detecting epigenetic BMI1 silencing.

Abstract: Implements and brackets for mounting implements on the lift arms of a working machine with a front end loader configuration are disclosed. The implements and brackets are configured to enable a user to mount the implement on the lift arms of the working machine in an inverted orientation, for example in order to mount a bucket that is typically used in a forward-facing orientation for digging or clearing in an inverted rearward facing position for piercing into the ground and performing a rearward scooping action. Some embodiment includes configurations for manual or powered adjustment of a lateral position of the implement in a direction transverse to the longitudinal axis of the working machine.

Abstract: Implements and brackets for mounting implements on the lift arms of a working machine with a front end loader configuration are disclosed. The implements and brackets are configured to enable a user to mount the implement on the lift arms of the working machine in an inverted orientation, for example in order to mount a bucket that is typically used in a forward-facing orientation for digging or clearing in an inverted rearward facing position for piercing into the ground and performing a rearward scooping action. Some embodiment includes configurations for manual or powered adjustment of a lateral position of the implement in a direction transverse to the longitudinal axis of the working machine.