Abstract: The invention relates to novel 21-alkylated steroids of the pregnane series having the formula: ##STR1## WHEREIN X = H or halogen;Y = h.sub.2, h(oh), h(oacyl), O or H(halogen);R.sub.1 = an alkyl group having 1-4 C-atoms;R.sub.2 = r.sub.1 or H;R.sub.3 = h, ch.sub.3 or halogen;Z = oh, oalkyl or Oacyl or form together with R.sub.4 a group as indicated below;Q = (when C.sub.15 -C.sub.16 is saturated) alkylidene having 1-4 C-atoms or (.beta.H) (.alpha.R.sub.4), in which R.sub.4 together with Z is alkylidenedioxy having 3-5 C-atoms, alkylidene having 1-4 C-atoms, aralkylidene having 7-8 C-atoms, alkylene of the formula ##STR2## wherein A = H or halogen and B = H, halogen, alkyl (1-4 C), haloalkyl, alkoxy or phenyl, or a [17.alpha.,16.alpha.-d]- or [16.alpha.,17.alpha.-d]-oxazolino-group, wherein the C-atom in 2'-position may be substituted by alkyl (1-4 C) or phenyl; or Q = (when C.sub.15 -C.sub.16 is unsaturated) methyl or halomethyl, and a process for obtaining same.

Abstract: The invention relates to novel alkylated steroids of the pregnane series having the formula: ##SPC1##, whereinX = a member of the group consisting of H and halogen;Y = a member of the group consisting of H.sub.2, H(OH), H(OAcyl) and O;R.sub.1 = a member of the group consisting of H, CH.sub.3 and halogen;R.sub.2 = alkyl having 1-4 carbon atoms;R.sub.3 = a member of the group consisting of H (except when Y = H.sub.2), OAcyl, Oalkyl, and CH.sub.3 ;R.sub.4 = a member of the group consisting of H and alkyl having 1-4 carbon atoms and in which at least one of the substituents R.sub.3 and R.sub.4 is alkyl; andC.sub.1 -c.sub.2 and C.sub.6 -C.sub.7 are selected from a saturated and an unsaturated bond.The novel compounds possess strong anti-inflammatory properties and are useful in the treatment of inflammatory conditions especially those associated with the skin and allergic reactions.