Patents by Inventor Gilbert Gorr
Gilbert Gorr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10822628Abstract: The present invention relates to a method of producing sesquiterpene lactones of the thapsigargin family, the method comprising the steps of: (a) culturing plant cells of the genus Thapsia in a nutrient medium in a suspension cell culture, wherein the cells produce one or more sesquiterpene lactones of the thapsigargin family; and (b) recovering one or more sesquiterpene lactones of the thapsigargin family produced in (a). The present invention further relates to a suspension cell culture comprising plant cells of the genus Thapsia, wherein the plant cells are capable of producing one or more sesquiterpene lactones of the thapsigargin family and to a plant cell biomass comprising plant cells of the genus Thapsia obtained from said suspension cell culture.Type: GrantFiled: December 2, 2014Date of Patent: November 3, 2020Assignee: Phyton Holdings, LLCInventors: Gilbert Gorr, Harald Heckenmüller, David Alexander Ullisch, Jens Stefan Wilke, Yantree Devi Sankar-Thomas
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Patent number: 10253098Abstract: The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.Type: GrantFiled: May 28, 2015Date of Patent: April 9, 2019Assignee: GREENOVATION BIOTECH GMBHInventors: Manfred Schuster, Ralf Kircheis, Andreas Nechansky, Wolfgang Jost, Gilbert Gorr
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Patent number: 10172306Abstract: The present invention relates to a method of producing Ingenol, Ingenol esters and/or Tiglian-3-one derivatives, the method comprising the steps of: (a) culturing plant cells obtained from a plant selected from the family Euphorbiaceae in a nutrient medium in a suspension cell culture, wherein the cells produce Ingenol, one or more Ingenol esters and/or one or more Tiglian-3-one derivatives; and (b) recovering the Ingenol, the one or more Ingenol esters and/or the one or more Tiglian-3-one derivatives produced in (a). The present invention further relates to a plant suspension cell culture, wherein the cells are obtained from a plant selected from the family Euphorbiaceae, and wherein the plant cells produce Ingenol and/or one or more Ingenol ester and/or one or more Tiglian-3-one derivatives.Type: GrantFiled: March 18, 2016Date of Patent: January 8, 2019Assignee: Phyton Holdings, LLCInventors: Gilbert Gorr, David Alexander Ullisch, Yantree Devi Sankar-Thomas, Thomas Selge, Thomas Leibold, Harald Heckenmüller
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Publication number: 20180042194Abstract: The present invention relates to a method of producing Ingenol, Ingenol esters and/or Tiglian-3-one derivatives, the method comprising the steps of: (a) culturing plant cells obtained from a plant selected from the family Euphorbiaceae in a nutrient medium in a suspension cell culture, wherein the cells produce Ingenol, one or more Ingenol esters and/or one or more Tiglian-3-one derivatives; and (b) recovering the Ingenol, the one or more Ingenol esters and/or the one or more Tiglian-3-one derivatives produced in (a). The present invention further relates to a plant suspension cell culture, wherein the cells are obtained from a plant selected from the family Euphorbiaceae, and wherein the plant cells produce Ingenol and/or one or more Ingenol ester and/or one or more Tiglian-3-one derivatives.Type: ApplicationFiled: March 18, 2016Publication date: February 15, 2018Applicant: Phyton Holdings, LLCInventors: Gilbert Gorr, David Alexander Ullisch, Yantree Devi Sankar-Thomas, Thomas Selge, Thomas Leibold, Harald Heckenmüller
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Publication number: 20160312255Abstract: The present invention relates to a method of producing sesquiterpene lactones of the thapsigargin family, the method comprising the steps of: (a) culturing plant cells of the genus Thapsia in a nutrient medium in a suspension cell culture, wherein the cells produce one or more sesquiterpene lactones of the thapsigargin family; and (b) recovering one or more sesquiterpene lactones of the thapsigargin family produced in (a). The present invention further relates to a suspension cell culture comprising plant cells of the genus Thapsia, wherein the plant cells are capable of producing one or more sesquiterpene lactones of the thapsigargin family and to a plant cell biomass comprising plant cells of the genus Thapsia obtained from said suspension cell culture.Type: ApplicationFiled: December 2, 2014Publication date: October 27, 2016Applicant: Phyton Holdings, LLCInventors: Gilbert Gorr, Harald Heckenmuller, David Alexander Ullisch, Jens Stefan Wilke, Yantree Devi Sankar-Thomas
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Publication number: 20150284461Abstract: The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.Type: ApplicationFiled: May 28, 2015Publication date: October 8, 2015Applicant: GREENOVATION BIOTECH GMBHInventors: Manfred Schuster, Ralf Kircheis, Andreas Nechansky, Wolfgang Jost, Gilbert Gorr
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Patent number: 9051577Abstract: The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that • the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and • at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.Type: GrantFiled: July 11, 2007Date of Patent: June 9, 2015Assignee: GREENOVATION BIOTECH GMBHInventors: Manfred Schuster, Ralf Kircheis, Andreas Nechansky, Wolfgang Jost, Gilbert Gorr
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Publication number: 20150065714Abstract: The invention relates to the production of alkaloids from Liliaceae cell culture.Type: ApplicationFiled: August 29, 2014Publication date: March 5, 2015Applicant: Phyton Holdings, LLCInventors: Venkatesh SRINIVASAN, Jennifer Alford, Beth Slusar-Place, Charles Swindell, Michael Horn, Khisal Alvi, Gilbert Gorr
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Patent number: 8877501Abstract: The present invention relates to the production of alkaloids from Liliaceae cell culture.Type: GrantFiled: June 18, 2010Date of Patent: November 4, 2014Assignee: Phyton Holdings, LLCInventors: Venkatesh Srinivasan, Jennifer Alford, Beth Slusar-Place, Charles Swindell, Michael Horn, Khisal Alvi, Gilbert Gorr
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Patent number: 8790928Abstract: A method of amplifying gene expression in a moss plant cell or moss tissue, DNA constructs therefor, moss plant cells and uses thereof for the production of protein.Type: GrantFiled: July 29, 2004Date of Patent: July 29, 2014Assignee: Greenovation Biotech GmbHInventor: Gilbert Gorr
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Publication number: 20120302754Abstract: The present invention relates to the production of alkaloids from Liliaceae cell culture.Type: ApplicationFiled: June 18, 2010Publication date: November 29, 2012Applicant: PHYTON HOLDINGS, LLCInventors: Venkatesh Srinivasan, Jennifer Alford, Beth Slusar-Place, Charles Swindell, Michael Horn, Khisal Alvi, Gilbert Gorr
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Patent number: 7834167Abstract: Disclosed are isolated nucleic acid molecules encoding wild type nucleus derived moss expression promoting regions (MEPRs) as well as a method for producing recombinant polypeptides using such MEPRs.Type: GrantFiled: June 6, 2008Date of Patent: November 16, 2010Assignee: Greenovation Biotech GmbHInventors: Marta Rodriguez-Franco, Wolfgang Jost, Andreas Weise, Gilbert Gorr
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Patent number: 7781197Abstract: Bryophyte plants and bryophyte plant cells comprising dysfunctional fucT and xylT genes and an introduced glycosyltransferase gene, methods for the production of glycosylated proteins therewith, vectors and uses thereof.Type: GrantFiled: December 18, 2003Date of Patent: August 24, 2010Assignee: greenovation Biotech GmbHInventors: Ralf Reski, Gilbert Gorr, Eva Decker, Christian Stemmer, Otmar Lienhart, Anna Koprivova
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Patent number: 7741539Abstract: The present invention relates to a method for producing heterologous glycosylated proteins in non-animal eukaryotic cells such as in transformed bryophyte, yeast, ciliate or algae cells. In particular, the method relates to a method for producing glycosylated proteins comprising animal glycosylation patterns—comprising sialic acid residues—, such as pharmaceutical proteins for use in mammals, e.g. humans, in bryophyte cells such as those of Physcomitrella patens, the genetic material required therefore, such as DNA and RNA, vectors, host cells, methods of introducing genetic material there into, and uses thereof. Furthermore, the present invention relates to novel polypeptides and proteins obtained by the method according to the invention. Moreover, the present invention provides a method of producing sialic acid or CMP-sialic acid in a transformed non-mammalian eukaryotic cell, tissue or organism.Type: GrantFiled: July 12, 2006Date of Patent: June 22, 2010Assignee: greenovation Biotech GmbHInventors: Gilbert Gorr, Heike Launhardt, Marta Rodriguez Franco, Christian Stemmer
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Publication number: 20100050292Abstract: The invention discloses DNA molecules encoding galactosyltransferases, recombinant host cells, tissues or organisms comprising dysfunctional galactosyltransferase gene(s), recombinant host cells, tissues or organisms comprising an introduced functional galactosyltransferase gene, methods for the production of proteins therewith, methods for the production of galactosyltransferase and vectors and uses thereof.Type: ApplicationFiled: September 28, 2007Publication date: February 25, 2010Applicant: GREENOVATION BIOTECH GMBHInventors: Heike Launhardt, Christian Stemmer, Wolfgang Jost, Gilbert Gorr, Ralf Reski, Stefan Rensing
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Publication number: 20090291078Abstract: The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that • the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and • at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.Type: ApplicationFiled: July 11, 2007Publication date: November 26, 2009Applicant: GREENOVATION BIOTECH GMBHInventors: Manfred Schuster, Ralf Kircheis, Andreas Nechansky, Wolfgang Jost, Gilbert Gorr
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Patent number: 7538259Abstract: Disclosed are isolated nucleic acid molecules encoding wild type nucleus derived moss expression promoting regions (MEPRs) as well as a method for producing recombinant polypeptides using such MEPRs.Type: GrantFiled: July 30, 2004Date of Patent: May 26, 2009Assignee: Greenovation Biotech GmbHInventors: Marta Rodriguez-Franco, Wolfgang Jost, Andreas Weise, Gilbert Gorr
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Publication number: 20090111187Abstract: Disclosed are isolated nucleic acid molecules encoding wild type nucleus derived moss expression promoting regions (MEPRs) as well as a method for producing recombinant polypeptides using such MEPRs.Type: ApplicationFiled: June 6, 2008Publication date: April 30, 2009Inventors: Marta Rodriguez-Franco, Wolfgang Jost, Andreas Weise, Gilbert Gorr
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Publication number: 20080248523Abstract: A method of amplifying gene expression in a moss plant cell or moss tissue, DNA constructs therefor, moss plant cells and uses thereof for the production of protein.Type: ApplicationFiled: July 29, 2004Publication date: October 9, 2008Applicant: Greenovation Biotech GMBHInventor: Gilbert Gorr
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Publication number: 20080201804Abstract: The present invention relates to a method for producing heterologous glycosylated proteins in non-animal eukaryotic cells such as in transformed bryophyte, yeast, ciliate or algae cells. In particular, the method relates to a method for producing glycosylated proteins comprising animal glycosylation patterns—comprising sialic acid residues—, such as pharmaceutical proteins for use in mammals, e.g. humans, in bryophyte cells such as those of Physcomitrella patens, the genetic material required therefore, such as DNA and RNA, vectors, host cells, methods of introducing genetic material there into, and uses thereof. Furthermore, the present invention relates to novel polypeptides and proteins obtained by the method according to the invention. Moreover, the present invention provides a method of producing sialic acid or CMP-sialic acid in a transformed non-mammalian eukaryotic cell, tissue or organism.Type: ApplicationFiled: July 12, 2006Publication date: August 21, 2008Inventors: Gilbert Gorr, Heike Launhardt, Christian Stemmer, Marta Rodriguez Franco