Patents by Inventor Gilbert J. Grant

Gilbert J. Grant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Liposomal analgesic drug compositions prepared in GMV using an ammonium sulfate gradient
    Patent number: 7357944
    Abstract: Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising ‘GMV’ (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: April 15, 2008
    Assignees: New York University, Yissum Research Development, Co
    Inventors: Elijah M. Bolotin, Gilbert J. Grant, Yechezkel Barenholz, Herman Turndorf, Boris Piskoun
  • Liposomak compositions and methods of preparation
    Patent number: 6926905
    Abstract: Long-term local anesthesia is provided by administering to a subject in need thereof a liposomal anesthetic formulation prepared by the dehydration-rehydration method. In this method, lyophilized liposomes encapsulating the local anesthetic are rehydrated by agitating them in an aqueous medium. Preferably this method includes the further step of washing the rehydrated liposomes in hyperosmotic saline solution.
    Type: Grant
    Filed: July 16, 2003
    Date of Patent: August 9, 2005
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, New York University
    Inventors: Gilbert J. Grant, Elijah M. Bolotin, Yechezkel Barenholz, Herman Turndorf
  • Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
    Publication number: 20040156891
    Abstract: Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising ‘GMV’ (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
    Type: Application
    Filed: February 5, 2004
    Publication date: August 12, 2004
    Applicants: New York University, Yissum Research Development Co. of the Hebrew University of Jerusalem
    Inventors: Elijah M. Bolotin, Gilbert J. Grant, Yechezkel Barenholz, Herman Turndorf, Boris Piskoun
  • Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
    Patent number: 6696080
    Abstract: Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising ‘GMV’ (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
    Type: Grant
    Filed: November 13, 2000
    Date of Patent: February 24, 2004
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, New York University
    Inventors: Elijah M. Bolotin, Gilbert J. Grant, Yechezkel Barenholz, Herman Turndorf, Boris Piskoun
  • Liposomak compositions and methods of preparation
    Publication number: 20040018230
    Abstract: Long-term local anesthesia is provided by administering to a subject in need thereof a liposomal anesthetic formulation prepared by the dehydration-rehydration method. In this method, lyophilized liposomes encapsulating the local anesthetic are rehydrated by agitating them in an aqueous medium. Preferably this method includes the further step of washing the rehydrated liposomes in hyperosmotic saline solution.
    Type: Application
    Filed: July 16, 2003
    Publication date: January 29, 2004
    Applicant: New York University
    Inventors: Gilbert J. Grant, Elijah M. Bolotin, Yechezkel Barenholz, Herman Turndorf
  • Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
    Patent number: 6162462
    Abstract: Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising `GMV` (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: December 19, 2000
    Assignees: New York University, Yissum Research Development Co. of the Hebrew Univ. of Jerusalem
    Inventors: Elijah M. Bolotin, Gilbert J. Grant, Yechezkel Barenholz, Herman Turndorf, Boris Piskoun