Patents by Inventor Gilbert Jay
Gilbert Jay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20060241015Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially expressed in prostate and breast cancers and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., cancers.Type: ApplicationFiled: January 24, 2003Publication date: October 26, 2006Inventors: Zairen Sun, Xuan Li, Gilbert Jay, Karl Kovacs, Wufang Fan, Youmin Shu
-
Patent number: 7115393Abstract: The present invention relates to all facets of novel polynucleotides for melanocortin-1 receptors, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially relating to melanocortin-1, such as melanoma, pigmentation disorders and conditions, inflammation, etc.Type: GrantFiled: June 10, 2002Date of Patent: October 3, 2006Assignee: OriGene Technologies, Inc.Inventors: Youmin Shu, Xuan Li, Anthony C. Yee, Gilbert Jay
-
Patent number: 7053193Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides, Urb-ctf, are expressed in breast cancer and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially related to breast cancer.Type: GrantFiled: January 25, 2002Date of Patent: May 30, 2006Assignee: Origene Technologies, Inc.Inventors: Zairen Sun, Wufang Fan, Karl F. Kovacs, Xuan Li, Gilbert Jay
-
Publication number: 20060026700Abstract: The present invention relates to genes and genes clusters which are expressed in a tissue specific maner. For example, the invention relates to a group of genes encoding GPCR-like receptors that are involved in the function and activity of the immune system. These genes are organized into a discrete cluster at chromosomal location 1q22 (the “immune gene complex”) and span about 700 kb of DNA. The region closest to the centromere comprises genes that are expressed predominantly in the thymus, while the distal region comprises genes which are expressed predominantly in the bone marrow and other hematopoietic cells. Another cluster of GPCR genes is located at chromosomal band 11q24. These genes are expressed predominantly in pancreatic tissue, establishing this region of chromosome 11 as a unique gene complex involved in pancreatic function. A cluster of transmembrane and GPCR-type receptor genes is also located at chromosomal band 11q12.2.Type: ApplicationFiled: April 15, 2003Publication date: February 2, 2006Applicant: Origene Technologies, Inc.Inventors: Gilbert Jay, Richard Lebovitz, Youmin Shu, Zairen Sun, Meng Wu
-
Patent number: 6953673Abstract: The present invention relates to the histamine H2 receptor (H2R), a member of the G-protein-coupled heptahelical receptor family. This novel H2 receptor codes for a novel carboxy-terminal tail which imparts important regulatory functions to the receptor, e.g., in down-regulation, signal transduction, and in coupling the activity of the H2R to downstream effector molecules, such as G-protein-coupled receptor kinases (GRK). The present invention relates to all facets of this new form of the H2R receptor, including nucleic acids that encode it, H2R polypeptides, binding-partners thereto, as well as its use in research, diagnosis, drug discovery, validation, and targeting, therapy, and clinical medicine.Type: GrantFiled: December 18, 2001Date of Patent: October 11, 2005Assignee: Origene Technologies, Inc.Inventors: Karl F. Kovacs, Gilbert Jay
-
Publication number: 20050120393Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in prostate and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions relating to prostate, such as prostate cancers, as well as other disease and conditions.Type: ApplicationFiled: August 2, 2002Publication date: June 2, 2005Applicant: OriGene Technologies, Inc.Inventors: Zairen Sun, Xuan Li, Gilbert Jay, Karl Kovacs, Youmin Shu, Wufang Fan
-
Publication number: 20050106579Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are modulated during angiogeneis and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, determining predisposition to, etc., diseases and conditions, such as abnormal, insufficient, excessive, etc.Type: ApplicationFiled: November 21, 2003Publication date: May 19, 2005Inventors: Zairen Sun, Xuan Li, Gilbert Jay
-
Publication number: 20050069886Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially-regulated in prostate cancer and are therefore useful in variety of ways. including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, to prostate cancer.Type: ApplicationFiled: November 7, 2002Publication date: March 31, 2005Inventors: Zairen Sun, Xuan Li, Gilbert Jay, Karl Kovacs, Wufang Fan
-
Publication number: 20050055733Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in small intestine or colon and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions relating to small intestine or colon.Type: ApplicationFiled: July 8, 2002Publication date: March 10, 2005Inventors: Zairen Sun, Xuan Li, Gilbert Jay, Karl Kovacs, Youmin Shu, Wufang Fan
-
Publication number: 20050019818Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.Type: ApplicationFiled: August 20, 2004Publication date: January 27, 2005Inventors: Youmin Shu, Wufang Fan, Karl Kovacs, Xuan Li, Gilbert Jay
-
Patent number: 6833247Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially-regulated in prostate cancer and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, to prostate cancer.Type: GrantFiled: May 14, 2002Date of Patent: December 21, 2004Assignee: Origene Technologies, Inc.Inventors: Zairen Sun, Xuan Li, Gilbert Jay
-
Publication number: 20040249144Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic/science and medicine, etc. The polynucleotides are differentially-regulated in breast cancer and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, predisposition to, etc., diseases and conditions relating to breast cancer.Type: ApplicationFiled: April 5, 2004Publication date: December 9, 2004Inventors: Zairen Sun, Xuan Li, Gilbert Jay, Karl F. Kovacs, Wufang Fan
-
Publication number: 20040248116Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drub discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially-regulated in prostate cancer and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, to prostate cancer.Type: ApplicationFiled: July 15, 2004Publication date: December 9, 2004Inventors: Zairen Sun, Gilbert Jay
-
Publication number: 20040234979Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic, etc. The polynucleotides are differentially expressed in cancers, especially breast cancers, and are therefore are useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating preventing or treating, determining predisposition to, etc., diseases and conditions, such as cancer and other cell-cycle diseases, especially relating to breast. The identification of specific genes, and groups of genes, expressed in a pathway physiologically relevant to cancer permits the definition of disease pathways and the delineation of targets in these pathways which are useful in diagnostic, therapeutic, and clinical applications.Type: ApplicationFiled: July 1, 2004Publication date: November 25, 2004Inventors: Zairen Sun, Gilbert Jay
-
Patent number: 6780595Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.Type: GrantFiled: February 26, 2002Date of Patent: August 24, 2004Assignee: Origene Technologies, Inc.Inventors: Youmin Shu, Wufang Fan, Karl F. Kovacs, Xuan Li, Gilbert Jay
-
Publication number: 20040023219Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially-regulated in prostate cancer and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, to prostate cancer.Type: ApplicationFiled: July 19, 2002Publication date: February 5, 2004Inventors: Zairen Sun, Xuan Li, Gilbert Jay
-
Publication number: 20030235826Abstract: The present invention relates to OTB182, and all facets of novel polynucleotides encoded by it, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in excitable tissues, such as heart, brain, and muscle, and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, such neuropathy, neuralgic amyotrophy (e.g., HNA), myopathy, sensorineural hearing loss (e.g., DFNA20), mental retardation, neuromuscular disorders, and other diseases especially relating to excitable tissues, such as heart, brain, and muscle.Type: ApplicationFiled: June 24, 2002Publication date: December 25, 2003Inventors: Youmin Shu, Xuan Li, Gilbert Jay
-
Publication number: 20030232339Abstract: The present invention relates to all facets of a novel polynucleotide, TRPCC, the polypeptides it encodes, antibodies, and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in brain, kidney, pituitary, and other tissues, and are therefore useful in a variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to brain and/or kidney disease, including diseases and conditions such as hypomagnesemia, hypocalcemia, and amyotrophic lateral sclerosis with frontotemporal dementia, etc.Type: ApplicationFiled: June 13, 2002Publication date: December 18, 2003Inventors: Youmin Shu, Xuan Li, Gilbert Jay
-
Publication number: 20030228658Abstract: The present invention relates to all facets of novel polynucleotides for melanocortin-1 receptors, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially relating to melanocortin-1, such as melanoma, pigmentation disorders and conditions, inflammation, etc. The identification of a specific genes expressed in pathways physiologically relevant to pigmentation and inflammation permits the definition of functional and disease pathways, and the delineation of targets in these pathways which are useful in diagnostic, therapeutic, and clinical applications.Type: ApplicationFiled: June 10, 2002Publication date: December 11, 2003Inventors: Youmin Shu, Xuan Li, Anthony C. Yee, Gilbert Jay
-
Patent number: 6657054Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are modulated during angiogeneis and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, determining predisposition to, etc., diseases and conditions, such as abnormal, insufficient, excessive, etc.Type: GrantFiled: June 10, 2002Date of Patent: December 2, 2003Assignee: Origene Technologies, Inc.Inventors: Zairen Sun, Xuan Li, Gilbert Jay