Patents by Inventor Gilbert Mouzin
Gilbert Mouzin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4409241Abstract: The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower-alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.Type: GrantFiled: September 20, 1982Date of Patent: October 11, 1983Assignee: Pierre Fabre S.A.Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger
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Patent number: 4382930Abstract: The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower-alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.Type: GrantFiled: December 29, 1980Date of Patent: May 10, 1983Assignee: Pierre Fabre S.A.Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger
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Patent number: 4380667Abstract: The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.Type: GrantFiled: September 19, 1979Date of Patent: April 19, 1983Assignee: Pierre Fabre S.A.Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger
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Patent number: 4372975Abstract: The invention relates to new substituted 2-benzoyl-4-chloroglycinanilide derivatives, to a process for their production and to their use as medicaments.The new derivatives according to the invention correspond to the general formula ##STR1## in which: R may be a linear or branched alkyl group, preferably a lower alkyl group;R.sub.1 and R.sub.2 may be the same or different and are selected from hydrogen, alkyl, alkenyl, alkynyl, hydroxy alkyl, alkoxy alkyl and aralkyl groups, these various groups optionally being linear or branched, and from 3- to 6-membered cycloalkyl groups optionally substituted on the .alpha.-carbon atom by an alkynyl radical;in addition, the groups R.sub.1 and R.sub.Type: GrantFiled: October 27, 1980Date of Patent: February 8, 1983Assignee: Pierre Fabre SAInventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger, Sylvano Casadio
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Patent number: 4370347Abstract: The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower-alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.Type: GrantFiled: October 19, 1981Date of Patent: January 25, 1983Assignee: Pierre Fabre S.A.Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger
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Patent number: 4289770Abstract: New derivatives of 2-benzoyl-4-nitro anilides, their preparation and their use as medicaments.The new chemical derivatives of the invention have the general formula ##STR1## in which R represents a linear or branched alkyl group, an alkenyl group, a cycloalkyl group or a benzyl group,R.sub.1 represents a hydrogen atom, an alkyl group or a hydroxy alkyl group,R.sub.2 represents a hydroxy-alkyl, alkenyl or alkynyl group, possibly substituted one or more times by an alkyl radical, or a cycloalkyl group having three to six carbon atoms;R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are attached, a nitrogen heterocycle containing possibly a second heteroatom selected from among oxygen and nitrogen;under the condition, however, that when R.sub.2 represents a hydroxy-alkyl group R.sub.1 may not be a hydrogen atom.Use as hypnotic agents for the treatment of insomnia.Type: GrantFiled: June 13, 1980Date of Patent: September 15, 1981Assignee: Pierre Fabre S.A.Inventors: Henri Cousse, Gilbert Mouzin
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Patent number: 4246271Abstract: The present invention relates to new derivatives of 4-phenyl-2-thiazolyl oxamates having the formula: ##STR1## in which: X represents hydrogen, halogen, lower-alkyl, or lower-alkoxy.R is lower-alkyl or phenyllower-alkyl, e.g., benzyl.These compounds, which have inhibiting properties on the passive cutaneous anaphylactic reaction, are useful in the treatment of asthma. Pharmaceutical compositions thereof and method of treating therewith.Type: GrantFiled: June 14, 1979Date of Patent: January 20, 1981Inventors: Henri Cousse, Gilbert Mouzin, Jean-Pierre Tarayre, Silvano Casadio
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Patent number: 4225610Abstract: The present invention concerns new derivatives of 4-phenyl 2-amino thiazole of the formula ##STR1## in which X represents a hydrogen atom, a halogen, a lower alkyl or an alkoxy,R is a hydrogen, a haloalkoxy, a substituted or unsubstituted aryl, a pyridyl, an aryloxy or a carboxy alkyl, having immunomodulating properties, useful in the treatment of rheumatoid arthritis and other ailments requiring immunotherapy.Type: GrantFiled: October 19, 1978Date of Patent: September 30, 1980Assignee: Pierre Fabre, S.A.Inventors: Jean-Pierre Tarayre, Henri Cousse, Gilbert Mouzin, Henri Lauressergues, Silvano Casadio
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Patent number: 4188387Abstract: The invention relates to new chemical compounds which can be used as analgesic drugs and their preparation.The new chemical compounds have the general formula: ##STR1## in which: R is a lower alkylR.sub.1, which is always other than H, is a linear or branched lower alkyl, an allyl, amino alkyl of type ##STR2## in which n=2 to 4, R.sub.2 R.sub.3 represent a lower alkyl; they may also form a heterocycle with the nitrogen atom.Y is a hydrogen, halogen, lower alkyl, alkoxy, ##STR3## R being a lower alkyl. The position of Y is variable on the ring.X=oxygen or sulfur atom.The drugs containing these active principles may be used in the treatment of rheumatismal disturbances and various pains.Type: GrantFiled: March 9, 1978Date of Patent: February 12, 1980Assignee: Pierre Fabre S.A.Inventors: Guy Pitet, Henri Cousse, Gilbert Mouzin, Antoine Stenger
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Patent number: 4167566Abstract: The invention relates to compounds of the formula ##STR1## in which R and R' are identical or different and may be a hydrogen, an alkyl, a dialkylamino, an alkoxy, a halogen, or a hydroxy. These compounds are useful as drugs in the control of thromboses.Type: GrantFiled: March 9, 1978Date of Patent: September 11, 1979Assignee: Pierre Fabre, S.A.Inventors: Guy Pitet, Henri Cousse, Gilbert Mouzin, Andre Delhon
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Patent number: 4152521Abstract: The invention concerns new chemical compounds which can be used as medicaments, their preparation, and pharmaceutical compositions, and method of treating therewith.The new chemical compounds have the general formula ##STR1## in which X, which is in 7 position, represents a halogen atom or a trifluoromethyl group.The medicaments containing these active principles may be used in the treatment of various pains, i.e., as analgesics.Type: GrantFiled: August 7, 1978Date of Patent: May 1, 1979Assignee: Pierre Fabre S.A.Inventors: Henri Cousse, Gilbert Mouzin
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Patent number: 4122181Abstract: The invention concerns new chemical compounds which can be used as medicaments, their preparation, and pharmaceutical compositions, and method of treating therewith.The new chemical compounds have the general formula ##STR1## in which X, which is in 7 position, represents a halogen atom or a trifluoromethyl group.The medicaments containing these active principles may be used in the treatment of various pains, i.e., as analgesics.Type: GrantFiled: December 10, 1976Date of Patent: October 24, 1978Assignee: Pierre Fabre S.A.Inventors: Henri Cousse, Gilbert Mouzin
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Patent number: 4098879Abstract: The present invention relates to new chemical compounds which can be used as inhibitors of dental plaque, and orally-acceptable compositions thereof, combinations thereof with known compounds having an inhibitory action on the formation of dental plaque, such as biguanidines, and method of treating therewith for the prevention of dental plaque or tartar and dental caries.The new compounds have the general formula ##STR1## in which R.sub.1 = H or alkylR.sub.2 = ch.sub.2 oh, alkyl carboxylate, ##STR2## and R.sub.2 is in 2 or 3 position.Compositions containing these active principles are useful in particular in the preventive treatment of periodontopathies and odontopathies and in the field of oral-dental hygiene.Type: GrantFiled: January 3, 1977Date of Patent: July 4, 1978Assignee: Pierre Fabre S.A.Inventors: Henri Cousse, Gilbert Mouzin, Jean-Claude Vezin, Lucien Dussourd d'Hinterland, Jacques Dubois
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Patent number: 4060637Abstract: The invention relates to new chemical compounds which can be used as drugs, as well as pharmaceutical compositions.The new products have the general formula: ##STR1## Drugs containing these active principles can be administered orally, rectally, parenterally or locally and are intended in particular for use as psychotropics, either alone or associated with other active principles. 5-Bromo-ortho-cresotamide may also be named 5-Bromo-2-hydroxy-3-methyl-benzamide.Type: GrantFiled: November 21, 1974Date of Patent: November 29, 1977Assignee: Pierre Fabre SAInventors: M. Antoine Stenger, Henri Cousse, M. Gilbert Mouzin
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Patent number: 4058558Abstract: This invention relates to new chemical compounds useful as drugs, as well as to pharmaceutical compositions containing the same.The new products are aromatic keto acid compounds with antiinflammatory as well as analgetic and hypocholesteremic activity and having the general formula ##STR1## wherein R.sub.1 is hydrogen, halogen, phenyl, halophenyl, phenoxy, or substituted phenoxy.R.sub.2 is hydrogen or alkoxy.R.sub.1 and R.sub.2 may form a ring, for instance: phenyl or cyclohexyl.R.sub.3 is always other than hydrogen, being either methyl (CH.sub.3) or methylene. When R.sub.3 is CH.sub.3, a double bond is present between the A and B carbons. When R.sub.3 is a methylene connected by a double bond to the B carbon, there can be only a single bond between the A and B carbons. The remaining valences of the A carbon atom are satisfied by hydrogen atoms.R.sub.Type: GrantFiled: March 21, 1975Date of Patent: November 15, 1977Assignee: Pierre Fabre S.A.Inventors: Henri Cousse, Gilbert Mouzin, Jean-Pierre Rieu
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Patent number: 4008323Abstract: This invention relates to new chemical compounds useful as drugs, as well as to pharmaceutical compositions containing the same. This application claims their hypocholesterolemic use.The new products are aromatic keto acid compounds with antiinflammatory as well as analgetic and hypocholesteremic acitvity and having the general formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, phenyl, halophenyl, alkyl, phenoxy, or substituted phenoxy.R.sub.2 is hydrogen or alkoxy. R.sub.1 and R.sub.2 may form a ring, for instance: phenyl or cyclohexyl. R.sub.3 is always other than hydrogen, being either methyl (CH.sub.3) or methylene.When R.sub.3 is CH.sub.3, a double bond is present between the A and B carbons. When R.sub.3 is a methylene connected by a double bond to the B carbon, there can be only a single bond between the A and B carbons. The remaining valences of the A carbon atom are satisfied by hydrogen atoms.R.sub.Type: GrantFiled: March 21, 1975Date of Patent: February 15, 1977Assignee: Pierre Fabre S.A.Inventors: Henri Cousse, Gilbert Mouzin, Jean-Pierre Rieu, Andre Delhon
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Patent number: 4006181Abstract: The present invention relates to a new process for the obtaining of dimethylaminoethyl acetylsalicylate and its salts.It is characterized by the fact that the synthesis of the acid chloride is effected in an aliphatic hydrocarbon in the presence of pyridine as catalyst; after condensation with the dimethylaminoethanol, the product obtained is recovered by crystallization in anhydrous medium.The products obtained can be used in the pharmaceutical industry.Type: GrantFiled: April 23, 1975Date of Patent: February 1, 1977Assignee: Pierre Fabre S.A.Inventors: Henri Cousse, Gilbert Mouzin
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Patent number: 3958002Abstract: 5-Bromo-N-(N.sup.1 -pyrrolidino-alkyl)-ortho-cresotamides having 2 to 5 carbon atoms in the alkyl moiety and therapeutically acceptable salts thereof, compositions containing such compounds useful as antitussives, and a method of suppressing of a cough in a host by administering an effective amount of such a compound with a pharmaceutically acceptable excipient. 5-Bromo-ortho-cresotamide may also be named 5-bromo-2-hydroxy-3-methyl-benzamide.Type: GrantFiled: January 6, 1975Date of Patent: May 18, 1976Assignee: Pierre Fabre S.A.Inventors: Antoine Stenger, Henri Cousse, Gilbert Mouzin
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Patent number: RE30309Abstract: The present invention relates to new chemical compounds which can be used as inhibitors of dental plaque, and orally-acceptable compositions thereof, combinations thereof with known compounds having an inhibitory action on the formation of dental plaque, such as biguanidines, and method of treating therewith for the prevention of dental plaque or tartar and dental caries.The new compounds have the general formula ##STR1## in which R.sub.1 =H or alkylR.sub.2 =CH.sub.2 OH, alkyl carboxylate, ##STR2## and R.sub.2 is in 2 or 3 position.Compositions containing these active principles are useful in particular in the preventive treatment of periodontopathies and odontopathies and in the field of oral-dental hydgiene.Type: GrantFiled: March 15, 1979Date of Patent: June 17, 1980Assignee: Pierre Fabre S.A.Inventors: Henri Cousse, Gilbert Mouzin, Jean-Claude Vezin, Lucien D. d'Hinterland, Jacques Dubois
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Patent number: RE31237Abstract: New derivatives of 2-benzoyl-4-nitro anilides, their preparation and their use as medicaments.The new chemical derivatives of the invention have the general formula ##STR1## in which R represents a linear or branched alkyl group, an alkenyl group, a cycloalkyl group or a benzyl group,R.sub.1 represents a hydrogen atom, an alkyl group or a hydroxy alkyl group,R.sub.2 represents a hydroxy-alkyl, alkenyl or alkynyl group, possibly substituted one or more times by an alkyl radical, or a cycloalkyl group having three to six carbon atoms;R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are attached, a nitrogen heterocycle containing possibly a second heteroatom selected from among oxygen and nitrogen;under the condition, however, that when R.sub.2 represents a hydroxy-alkyl group R.sub.1 may not be a hydrogen atom.Use as hypnotic agents for the treatment of insomnia.Type: GrantFiled: February 19, 1982Date of Patent: May 10, 1983Assignee: Pierre Fabre S.A.Inventors: Henri Cousse, Gilbert Mouzin