Patents by Inventor Gilbert Rosseels

Gilbert Rosseels has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5444056
    Abstract: An aminoalkoxyphenyl derivative of general formula:Cy--B--Ph--O--A--Am (1)as well as a pharmaceutically acceptable salt thereof in whichB represents a --S--, --SO-- or --SO.sub.2 -- group,Ph represents an optionally substituted phenyl radical,A denotes a straight or branched alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxy propylene radical in which the hydroxy is optionally substituted by a C.sub.1 -C.sub.4 alkyl radical.Am represents a group: ##STR1## and Cy is a cyclic group, provided that when Cy represents either a benzo[b]furyl group substituted at position 4 by a halogen atom or a C.sub.1 -C.sub.4 alkyl group, or a benzo[b]thienyl group substituted at position 4 by a halogen atom or by a C.sub.1 -C.sub.4 alkyl group and when B represents a --SO.sub.2 -- group, R.sub.3 represents a --Alk--Ar radical.
    Type: Grant
    Filed: February 7, 1990
    Date of Patent: August 22, 1995
    Assignee: Sanofi
    Inventors: Jean Gubin, Pierre Chatelain, Henri Inion, Gilbert Rosseels
  • Patent number: 5223510
    Abstract: The subject of the invention is benzofuran, benzothiophene, indole or indolizine compounds of general formula: ##STR1## in which: Het represents one of the groups: ##STR2## in which T,T' and T"represent particularly a group: ##STR3## R and R.sub.a, identical or different, represent X represent --O-- or --S--Y represents a radical ##STR4## These compounds are useful as medecines particularly for the treatment of pathological syndroms of the cardio-vascular system.
    Type: Grant
    Filed: July 26, 1991
    Date of Patent: June 29, 1993
    Assignee: Sanofi
    Inventors: Jean Gubin, Pierre Chatelain, Jean Lucchetti, Gilbert Rosseels, Henri Inion
  • Patent number: 4520026
    Abstract: Novel indolizine derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: R represents an alkyl radical having from 1 to 8 carbon atoms, or a phenyl group non-substituted or bearing one or two substituents, selected from halogen atoms and from lower alkyl and alkoxy groups,X.sub.1 represents hydrogen, chlorine, bromine, iodine, methyl or methoxy,A represents a group selected from: ##STR2## in which X.sub.2 represents hydrogen, chlorine, bromine, iodine, methyl or methoxy and X.sub.3 represents hydrogen, chlorine, bromine, iodine or methyl,R.sub.1 represents a methyl, ethyl, n-propyl or n-butyl radical,n represents an integer in the range of 2 to 6 inclusive,with the proviso that when both X.sub.2 and X.sub.3 represent hydrogen or methyl, X.sub.1 is other than hydrogen.They are effective for treating pathological syndromes of the heart and particularly angina pectoris and cardiac arrhythmias.
    Type: Grant
    Filed: June 29, 1982
    Date of Patent: May 28, 1985
    Assignee: S. A. Labaz N.V.
    Inventors: Gilbert Rosseels, Henri Inion
  • Patent number: 4499095
    Abstract: Indolizine derivatives corresponding to the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: R represents a straight- or branched-chain alkyl radical having from 1 to 4 carbon atoms or a phenyl radical, R.sub.1 represents a straight- or branched-chain alkyl radical having from 1 to 6 carbon atoms, X.sub.1 represents hydrogen, chlorine, bromine, methyl or methoxy, A represents a radical of the formula: ##STR2## in which X.sub.2 represents hydrogen, chlorine, bromine, methyl or methoxy, n represents 1 or 2, a process for preparing said derivatives, pharmaceutical or veterinary compositions containing at least one of said derivatives and a method of treating pathological syndromes of the heart by administration of at least one of said derivatives to a subject in need of such treatment.
    Type: Grant
    Filed: June 7, 1983
    Date of Patent: February 12, 1985
    Assignee: Sanofi
    Inventors: Gilbert Rosseels, Peter Polster
  • Patent number: 4400387
    Abstract: Indolizine derivatives represented by the general formula: ##STR1## wherein R represents a straight- or branched-chain alkyl radical having from 1 to 8 carbon atoms, or a phenyl group non-substituted or bearing one or two substituents, which may be the same or different, selected from halogen atoms, for example fluorine, chlorine and bromine and from lower alkyl and alkoxy groups, for example methyl and methoxy and X.sub.1, X.sub.2 and X.sub.3, which may be the same or different, each represent hydrogen, chlorine, bromine or methoxy with the proviso that when they are identical X.sub.1, X.sub.2 and X.sub.3 are not simultaneously hydrogen.They possess an inhibitory activity with respect to the action of xanthine oxidase and of adenosine deaminase as well as an uricosuric action and can be used in the treatment of physiological disturbances consequent upon an excess of uric acid, upon disorders of the immunization system and as antiparasitic agents.
    Type: Grant
    Filed: June 30, 1980
    Date of Patent: August 23, 1983
    Assignee: S. A. Labaz-Sanofi N.V.
    Inventors: Gilbert Rosseels, Pierre Nokin
  • Patent number: 4378362
    Abstract: Novel indolizine derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: R represents an alkyl radical having from 1 to 8 carbon atoms, or a phenyl group non-substituted or bearing one or two substituents, selected from halogen atoms and from lower alkyl and alkoxy groups,X.sub.1 represents hydrogen, chlorine, bromine, iodine, methyl or methoxy,A represents a group selected from: ##STR2## in which X.sub.2 represents hydrogen, chlorine, bromine, iodine, methyl or methoxy and X.sub.3 represents hydrogen, chlorine, bromine, iodine or methyl,R.sub.1 represents a methyl, ethyl, n-propyl or n-butyl radical,n represents an integer in the range of 2 to 6 inclusive,with the proviso that when both X.sub.2 and X.sub.3 represent hydrogen or methyl, X.sub.1 is other than hydrogen.They are effective for treating pathological syndromes of the heart and particularly angina pectoris and cardiac arrhythmias.
    Type: Grant
    Filed: February 6, 1981
    Date of Patent: March 29, 1983
    Assignee: S.A. Labaz N.V.
    Inventors: Gilbert Rosseels, Henri Inion
  • Patent number: 4103012
    Abstract: Novel indolizine derivatives of the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R represents a branched- or straight-chain alkyl radical having from 1 to 5 carbon atoms, a phenyl radical, a mono-fluoro-, mono-chloro- or mono-bromo-phenyl, a di-fluoro-, di-chloro- or di-bromo-phenyl radical, a methoxy-phenyl radical or a methyl-phenyl radical optionally substituted on the aromatic moiety by an atom of fluorine, chlorine or bromine and R.sub.1 and R.sub.2, which are different, represent a hydrogen atom or a group of the formula: ##STR2## wherein R.sub.3 and R.sub.4 which are identical, each represent a hydrogen atom or a methyl radical, Am represents a dimethylamino, diethylamino, di-n-propylamino, di-n-butylamino, morpholino, piperidino, pyrrolidino or 4-methyl-piperazino group and n is an integer in the range of from 2 to 6 inclusive.
    Type: Grant
    Filed: February 16, 1977
    Date of Patent: July 25, 1978
    Assignee: Labaz
    Inventors: Jean Gubin, Gilbert Rosseels