Abstract: Disclosed are methods of treatment including administration of a pharmaceutical composition including brimonidine to an eye as a mist, the composition devoid of a penetration enhancer.

Abstract: The present invention is directed to methods for detecting and evaluating retinal affecting neurodegenerative diseases. A plurality of selected retinal parameters are measured generating an eyeprint signature for a subject. The eyeprint signature can be used to evaluate whether the subject is suffering from a retinal affecting neurodegenerative disease, to monitoring the progression of the neurodegenerative disease, as well as to monitor the effectiveness of a treatment for the neurodegenerative disease.

Abstract: A laser source attached to an ophthalmic observation instrument, such as a fundus camera, projects a spot, and a light collector is positioned in the image field of the instrument over the spot to collect return light scattered from a homogeneous tissue bed in the image field. The collected light is directed onto a photomultiplier and digitized at a sampling rate above several kHz to provide a continuous data stream which is fed to a process/control module that operates to automatically define a number n of sample intervals, select a subset of the sample intervals for analysis, transform the selected intervals, and evaluate the shape of the transformed sample intervals. The process/control module may be implemented on a simple computer, and include a user interface which indicates status of signal acquisition, selection and evaluation during a short, e.g., one-minute illumination interval.

Abstract: A beam steering optical system having a system pupil includes an irradiating optical system producing an irradiating light beam for irradiating an object. The system also includes a two-sided rotatable mirror positioned to cover only a first portion of the system pupil and to receive and reflect with a first surface the irradiating light beam. An objective lens receives the irradiating light beam reflected from the mirror and focuses the irradiating light beam on the object. These elements together define an irradiation path for the irradiating light beam. When reflected by the object, the irradiating light beam is denoted as a detecting light beam. The objective lens receives the detecting light beam reflected by the object and directs it to a second portion of the system pupil not covered by mirror.