Abstract: The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.

Abstract: The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.

Abstract: The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.

Abstract: The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.

Abstract: The present invention provides muscarinic M4 receptor agonists of formula (I) and pharmaceutically acceptable salts thereof, wherein m, n, p, q, R, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases such as schizophrenia, Alzheimer's disease and various cognitive disorders as well as in the treatment or alleviation of pain.

Abstract: The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.

Abstract: The present invention provides muscarinic M4 receptor agonists of formula (I) and pharmaceutically acceptable salts thereof, wherein m, n, p, q, R, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases such as schizophrenia, Alzheimer's disease and various cognitive disorders as well as in the treatment or alleviation of pain.

Abstract: The present invention provides muscarinic M4 receptor agonists of formula (I) and pharmaceutically acceptable salts thereof, wherein m, n, p, q, R, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases such as schizophrenia, Alzheimer's disease and various cognitive disorders as well as in the treatment or alleviation of pain.

Abstract: A dump body which dissuades material from sitting on a top surface of a sidewall of the dump body and thereby reduces spillage while hauling material is disclosed. The dump body may additionally allow an operator of a loader to clearly distinguish the edge of the dump body to facilitate loading and reduce structural damage. The dump body may further create a lower center of gravity while hauling the same payload, which may reduce the risk of rolling the dump body. The dump body may include a pair of sidewalls attached on opposing sides of a bottom wall and extending upwardly, with each having a top surface inclined toward an interior of the dump body. The incline may start at an inside edge of the sidewall and extend upwardly to an outside edge of the sidewall residing at a very outer extent of the sidewall.

Abstract: Disclosed are compounds that are antagonists of the CXCR4 receptor.

Abstract: The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.

Abstract: The present invention provides muscarinic M4 receptor agonists of formula (I) and pharmaceutically acceptable salts thereof, wherein m, n, p, q, R, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases such as schizophrenia, Alzheimer's disease and various cognitive disorders as well as in the treatment or alleviation of pain.

Abstract: This invention relates to compounds that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula I, where n is 1 or 2; p is 0, 1 or 2; q is 0, 1 or 2; and R1-R6 are as defined herein.

Abstract: This invention relates to compounds that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula I, where n is 1 or 2; p is 0, 1 or 2; q is 0, 1 or 2; and R1-R6 are as defined herein.

Abstract: A hitch assembly is disclosed for use with an articulated mobile machine. The hitch assembly may have a yoke portion, a tube portion, a driveshaft, and a hitch carrier to rotationally support the driveshaft inside the tube portion and having a plurality of first holes. The hitch assembly may further have a plurality of fasteners to connect the hitch carrier to the tube portion via the plurality of first holes, and a thrust collar to threadingly engage a periphery of the hitch carrier and having a plurality of second holes. The hitch assembly may additionally have a locking plate with at least one pin to engage at least one of the plurality of second holes, and a plurality of third holes to receive at least some of the plurality of fasteners. The number of the plurality of second holes is greater than the number of the plurality of first holes.

Abstract: A bumper assembly is disclosed for use with a mobile machine. The bumper assembly may have a heat exchanger, and a bumper configured to support the heat exchanger. The bumper may have a recess formed in an upper surface and located to provide a clearance space around a lower portion of the heat exchanger.

Abstract: A bumper assembly is disclosed for use with a mobile machine. The bumper assembly may have a heat exchanger, and a bumper configured to support the heat exchanger. The bumper may have a recess formed in an upper surface and located to provide a clearance space around a lower portion of the heat exchanger.

Abstract: A hitch assembly is disclosed for use with an articulated mobile machine. The hitch assembly may have a yoke portion, a tube portion, a driveshaft, and a hitch carrier to rotationally support the driveshaft inside the tube portion and having a plurality of first holes. The hitch assembly may further have a plurality of fasteners to connect the hitch carrier to the tube portion via the plurality of first holes, and a thrust collar to threadingly engage a periphery of the hitch carrier and having a plurality of second holes. The hitch assembly may additionally have a locking plate with at least one pin to engage at least one of the plurality of second holes, and a plurality of third holes to receive at least some of the plurality of fasteners. The number of the plurality of second holes is greater than the number of the plurality of first holes.

Abstract: A dump body which dissuades material from sitting on a top surface of a sidewall of the dump body and thereby reduces spillage while hauling material is disclosed. The dump body may additionally allow an operator of a loader to clearly distinguish the edge of the dump body to facilitate loading and reduce structural damage. The dump body may further create a lower center of gravity while hauling the same payload, which may reduce the risk of rolling the dump body. The dump body may include a pair of sidewalls attached on opposing sides of a bottom wall and extending upwardly, with each having a top surface inclined toward an interior of the dump body. The incline may start at an inside edge of the sidewall and extend upwardly to an outside edge of the sidewall residing at a very outer extent of the sidewall.

Abstract: Disclosed are compounds that are antagonists of the CXCR4 receptor.