Patents by Inventor Gill Anlezark

Gill Anlezark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nitroreductase enzymes
    Publication number: 20040014191
    Abstract: Nitroreductases, and genes encoding the same, are provided that demonstrate preferential catalytic conversion of the alkylating agent CB1954 into its highly cytotoxic 4-hydroxylamine (4HX) derivative, this derivative demonstrating anticarcinoma properties. Accordingly, the catalytic activity of the nitroreductase enzymes of the present invention may be employed to achieve catalysis of CB1954 into its cytotoxic derivative in a site-directed manner, such as by Directed-Enzyme Prodrug Therapy (DEPT).
    Type: Application
    Filed: February 12, 2003
    Publication date: January 22, 2004
    Inventors: Nigel Minton, Gill Anlezark, Thomas Vaughan