Patents by Inventor Gilles Audoly

Gilles Audoly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Yeast-based assay for measuring the functional activity of an HIV-1 protease in response to an antiviral agent
    Patent number: 9493769
    Abstract: A method of determining sensitivity or resistance of isolates of HIV retroviruses to a molecule includes a) amplifying sequences coding for a protease of a retrovirus to be studied, with or without the or some of amino acid sequences situated upstream and downstream of a cleavage site of a precursor in which the amino acid sequences are situated, b) recombining fragments of DNA, a final product of the amplification, and an expression vector allowing expression of sequence coding for the protease of the retrovirus to be studied under control of a known inducible promoter through co-transformation of the vector and the DNA fragments with at least one yeast cell, c) culturing co-transformed yeast cell or cells to obtain a sufficient number of transformants to perform a sensitivity or resistance test, and recovering transformants issuing from the co-transformed cell, on any suitable medium, d) incubating the transformants in the presence of a molecule to be tested, e) qualitatively or quantitatively analyzing the
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: November 15, 2016
    Assignees: UNIVERSITE D'AIX-MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS
    Inventors: Pablo Gluschankof, Didier Raoult, Najoua Ben M'Barek, Gilles Audoly, Christelle Perrin-East
  • Methods for determining human immunodeficiency virus type 2 (HIV-2) protease sensitivity or resistance to antivirals utilizing an inducible yeast expression system
    Patent number: 7989161
    Abstract: A method for determining sensitivity or resistance of isolates of HIV (human immunodeficiency virus) retroviruses to chemical molecules having an inhibiting activity on a viral protease or to therapeutic treatments based on inhibitors of the viral protease, including causing cell lysis of at least one yeast by expression of the retrovirus protease.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: August 2, 2011
    Assignees: Université de la Méditérranée, Centre National de la Recherche Scientifique - CNRS
    Inventors: Pablo Gluschankof, Didier Raoult, Najoua Ben M'Barek, Gilles Audoly
  • METHOD FOR DETERMINING THE SENSITIVITY OR RESISTANCE OF RETROVIRUS ISOLATES TO MOLECULES, THERAPEUTIC RETROVIRAL TREATMENTS BASED ON VIRAL PROTEASE INHIBITORS AND DIAGNOSTIC KITS
    Publication number: 20100028891
    Abstract: A method of determining sensitivity or resistance of isolates of HIV retroviruses to a molecule includes a) amplifying sequences coding for a protease of a retrovirus to be studied, with or without the or some of amino acid sequences situated upstream and downstream of a cleavage site of a precursor in which the amino acid sequences are situated, b) recombining fragments of DNA, a final product of the amplification, and an expression vector allowing expression of sequence coding for the protease of the retrovirus to be studied under control of a known inducible promoter through co-transformation of the vector and the DNA fragments with at least one yeast cell, c) culturing co-transformed yeast cell or cells to obtain a sufficient number of transformants to perform a sensitivity or resistance test, and recovering transformants issuing from the co-transformed cell, on any suitable medium, d) incubating the transformants in the presence of a molecule to be tested, e) qualitatively or quantitatively analyzing the
    Type: Application
    Filed: July 16, 2009
    Publication date: February 4, 2010
    Applicants: UNIVERSITE DE LA MEDITERRANEE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS
    Inventors: Pablo Gluschankof, Didier Raoult, Najoua Ben M'Barek, Gilles Audoly, Christelle Perrin-East
  • Methods for determining the sensitivity or resistance of retrovirus isolates to therapeutic retroviral treatments based on viral protease inhibitors and diagnostic kits
    Publication number: 20090104595
    Abstract: A method for determining sensitivity or resistance of isolates of HIV (human immunodeficiency virus) retroviruses to chemical molecules having an inhibiting activity on a viral protease or to therapeutic treatments based on inhibitors of the viral protease, including causing cell lysis of at least one yeast by expression of the retrovirus protease.
    Type: Application
    Filed: June 2, 2005
    Publication date: April 23, 2009
    Applicants: Universite de La Mediterranee, Centre National de La Recherche Scientifique- CNRS
    Inventors: Pablo Gluschankof, Didier Raoult, Najoua Ben M'Barek, Gilles Audoly