Abstract: An electro-chemical surgical knife is detailed that in a single instrument provides both a chemically assisted mechanical dissector and an electrical knife. The chemically assisted mechanical dissector: includes a conductive mechanical instrument, a source (7) of a cleavage solution, a pump (8) for feeding the cleavage solution to, a channel (2) for transporting the cleavage solution to an operating location, and a flow controller (8c) for controlling the feeding of the cleavage solution by the pump to an inlet of the channel. The electric knife includes a source of high frequency AC electrical power (5) for feeding AC current through an electric conductor (3) to, an electrode (6) formed by the conductive mechanical instrument and further comprises a second controller (5c) for controlling the feeding of the AC current to the electrode.

Abstract: A device and a method for delivering a solution to tissues and/or organs. The solution contains at least one solvent and at least one solute. The device includes at least one chamber which contains sodium 2-mercaptoethanesulfonate in powder form. The method includes the steps of dissolving the solute in the solvent inside the device. The resulting solution is delivered immediately to tissues and/or organs to facilitate dissection.

Abstract: A device and a method for delivering a solution to tissues and/or organs. The solution contains at least one solvent and at least one solute. The device includes at least one chamber which contains sodium 2-mercaptoethanesulfonate (Mesna) in powder form. The method includes dissolving the solute in the solvent inside the device. The resulting solution is delivered immediately to tissues and/or organs to facilitate dissection. A composition including Mesna and one or more dye which is used in a method of surgery, a kit including Mesna, and a method for visualization of a composition including Mesna which is applied to tissues. A method for producing a composition including Mesna for use in a method of surgery, a kit for obtaining a composition including Mesna for use in a method of surgery, a device for chemically assisted tissue dissection facilitated by Mesna, and a method of surgery using Mesna.

Abstract: A device for delivering a sodium-2-mercaptoethane (Mesna) formulation to tissues and/or organs. The device includes a first chamber including Mesna in solid form, a second chamber including a buffer and at least one outlet for delivering the Mesna formulation, the outlet is. being in fluid communication with at least one of the chambers. The chambers are separated from each other by at least one disruptable separator and are in fluid communication with each other upon disruption of the separator thereby forming the Mesna formulation. The pH of the buffer in the second chamber is at least 8.5. A process for the preparation of a Mesna formulation.

Abstract: An electro-chemical surgical knife is detailed that in a single instrument provides both a chemically assisted mechanical dissector and an electrical knife. The chemically assisted mechanical dissector: includes a conductive mechanical instrument, a source, (7), of cleavage solution, a pump, (8), for feeding the cleavage solution to, a channel, (2), for transporting the cleavage solution to the operating location, and a flow controller, (8c), for controlling the volumetric feeding of cleavage solution by the pump to the channel inlet. The electric knife includes a source of high frequency AC electrical power, (5), for feeding AC current through an electric conductor, (3), to, an electrode, (6), formed by the conductive mechanical instrument and further comprises A second controller, (5c), for controlling the feeding of electric current to the electrode.

Abstract: A sterile lyophilizate composition having improved stability and shelf-life. The lyophilizate includes from 30 to 100% of Mesna and 0 to 70% of an excipient. A process for the preparation of the sterile lyophilizate composition and a dosage unit formulation including the lyophilizate composition.

Abstract: A device and a method for delivering a solution to tissues and/or organs. The solution contains at least one solvent and at least one solute. The device includes at least one chamber which contains sodium 2-mercaptoethanesulfonate in powder form. The method includes the steps of dissolving the solute in the solvent inside the device. The resulting solution is delivered immediately to tissues and/or organs to facilitate dissection.

Abstract: The invention provides a sterile lyophilizate composition having improved stability and shelf-life, the lyophilizate having from 30 to 100% of Mesna and 0 to 70% of an excipient. The invention further provides a process for the preparation of the sterile lyophilizate composition and a dosage unit formulation with the lyophilizate composition.

Abstract: A device and a method for delivering a solution to tissues and/or organs is described. The solution contains at least one solvent and at least one solute. The device includes at least one chamber which contains sodium 2-mercaptoethanesulfonate in powder form. The method includes the steps of dissolving the solute in the solvent inside the device. The resulting solution is delivered immediately to tissues and/or organs to facilitate dissection.

Abstract: A sterile lyophilizate composition having improved stability and shelf-life. The lyophilizate includes from 30 to 100% of Mesna and 0 to 70% of an excipient. A process for the preparation of the sterile lyophilizate composition and a dosage unit formulation including the lyophilizate composition.

Abstract: The invention provides a sterile lyophilizate composition having improved stability and shelf-life, the lyophilizate having from 30 to 100% of Mesna and 0 to 70% of an excipient. The invention further provides a process for the preparation of the sterile lyophilizate composition and a dosage unit formulation with the lyophilizate composition.

Abstract: The invention provides a sterile lyophilizate composition having improved stability and shelf-life, the lyophilizate comprising from 30 to 100% of Mesna and 0 to 70% of an excipient. The invention further provides a process for the preparation of said sterile lyophilizate composition and a dosage unit formulation comprising said lyophilizate composition.

Abstract: A device and a method for delivering a solution to tissues and/or organs is described. The solution contains at least one solvent and at least one solute. The device includes at least one chamber which contains sodium 2-mercaptoethanesulfonate in powder form. The method includes the steps of dissolving the solute in the solvent inside the device. The resulting solution is delivered immediately to tissues and/or organs to facilitate dissection.