Abstract: The present invention relates to the field of oncology. laboratory tools and methods, and especially anti-tumor DNA crosslinking agents. Most patients with advanced solid tumors develop resistance to chemotherapy due to the ability of cancer cells to repair or tolerate sustained DNA damages. The inventors showed that the compounds according to the present invention allow the detection and visualization of alkylated DNA damages induced by PBDs without altering their DNA crosslinking ability. This enables the study of the effect and properties of PBDs. In particular, the present invention relates new derivates of PBD molecules and their synthesis. The present invention also relates to a method for visualizing DNA crosslinking: to a method for assessing the resistance of a tumor to a crosslinking agent and to a method for identifying a molecule or treatment for improving the efficiency of a crosslinking agent.

Abstract: A pressure cooker pressure regulator having at least two operating thresholds, the regulator being of the type comprising a valve body fixed to the lid of a pressure cooker and having a valve seat formed therein, and a needle carrying a rating mass and bearing against the seat, the regulator is such that the needle is slidably mounted relative to the rating mass, that a spring is interposed between the needle and the rating mass, and that means are provided for adjusting the force exerted by the spring on the needle and comprising means selectively implemented to oppose upward displacement of the rating mass relative to the valve body under the effect of pressure applied to the needle via the seat.

Abstract: The sluice oscillates about a shaft (16) in order to control the level of a downstream reach (4) to occupy a reference level as defined by the position of an opening (36) for connection to the atmosphere and suitable for being closed by a needle (38) carried on a float (40). The plate (6) is driven by a caisson (18) which is immersed in the upstream reach (2) and which contains a quantity of water (28) that is increased by sucking air via a hydraulic Venturi (50) driven by the flow of water between the two reaches. The displacements of the float (40) control the pressure reduction which is actually applied to said caisson in such a manner as to obtain the desired level control. The invention is applicable to controlling irrigation networks.

Abstract: A sluice gate is provided in the form of a vane wheel on a horizontal shaft mounted transversally across the sluice in which it is installed, said vanes being distributed about the shaft and being partially immersible for the purpose of gate operation, same said vanes providing different sluice closing surface areas and said sluice gate comprising wheel locking means to maintain the vanes fixedly in the sluice. Application in small irrigation sluices is suggested.

Abstract: An energy-efficient automatic sluice gate for sustaining a fluid level, separating an upstream pool from a downstream pool in an irrigation system and enabling the level of water in one of the pools to be kept constant at a settable value.

Abstract: The valve includes a disk (8) one side of which is subjected to the action of an adjustable thrust unit and the other side of which is applied against a seat (3) connected to the pressure source of said hydraulic installation, the thrust unit (12) being constituted by an adjustably pressurized deformable chamber. The valve is used in particular for protecting hydraulic installations e.g. water pipes against accidental overpressures, e.g. water-hammer.

Abstract: Apparatus for increasing the homogeneity of the mixture of fluids, e.g. petroleum products flowing together in a pipe. The apparatus operates by dividing the flow into multiple converging jets and comprises a tubular body (10) for insertion in the pipe. The tubular body (10) houses a cylindrical sheath (9) inside which two plates (21, 22) provided with perforations (23) define two inlet chambers (25, 26) between which the flow is distributed. The space (33) between the plates is partitioned by a plurality of partitions (36) which are substantially perpendicular to the axis of the sheath so as to constitute outlet cells in which jets from the perforations of the plates converge. Said outlet cells have openings (38) formed in the sheath for the lateral removal of the fluids which mix therein.