Abstract: The present invention relates to a process for preparing hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]-3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester of formula (I). In accordance with the present invention, the compound (I) can be efficiently prepared with high purity by coupling bimatoprost in a boronate protected form with 6-(nitrooxy)hexanoyl chloride and removing the boronate protecting group. The invention also relates to a process for the preparation of 6-(nitrooxy) hexanoic acid having a HPLC purity equal to or greater than 99% and containing an amount of 6-{[6-(nitrooxy)hexanoyl]oxy}hexanoic acid (compound (IXa) equal to or lower than 0.2%.

Abstract: The present disclosure relates to a tower comprising a fluid transporting pipe (24) and an element (29) for anchoring a transporting pipe (24) to the bottom (14) of the expanse of water (12), which element is connected to an upstream point (38) of an intermediate section (30) of the pipe. The tower comprises a buoy (26) connected to a downstream point (40) of the intermediate section in order to keep the intermediate section (40) in a substantially vertical configuration. The buoy (26) has a height less than 1.5 times its maximum transverse direction and delimits a first through-passage (78A) in which the intermediate section (30) is fitted. The buoy (26) delimits a second through-passage (78B), separate from the first through-passage (78A), the second through-passage (78B) accepting the upper section (34). The tower (20) comprises a coupling section (32) that couples the connecting upper section (34) to the intermediate section (30).

Abstract: The present disclosure relates to a tower comprising a fluid transporting pipe (24) and an element (29) for anchoring a transporting pipe (24) to the bottom (14) of the expanse of water (12), which element is connected to an upstream point (38) of an intermediate section (30) of the pipe. The tower comprises a buoy (26) connected to a downstream point (40) of the intermediate section in order to keep the intermediate section (40) in a substantially vertical configuration. The buoy (26) has a height less than 1.5 times its maximum transverse direction and delimits a first through-passage (78A) in which the intermediate section (30) is fitted. The buoy (26) delimits a second through-passage (78B), separate from the first through-passage (78A), the second through-passage (78B) accepting the upper section (34). The tower (20) comprises a coupling section (32) that couples the connecting upper section (34) to the intermediate section (30).