Patents by Inventor Gilles Divita

Gilles Divita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS
    Publication number: 20230304010
    Abstract: The present application provides peptides and nucleic acids that are useful for treating virus (e.g., SARS-CoV-2) infection. Exemplary peptides comprise chimeric peptides and blocking peptides that block the interaction between SPIKE and ACE2. Exemplary nucleic acids include siRNAs that specifically target SARS-CoV-2. The present applications also provide complexes and nanoparticles further comprising a second peptide (e.g., a cell-penetrating peptide) that promotes intracellular delivery of the peptides and nucleic acids.
    Type: Application
    Filed: July 23, 2021
    Publication date: September 28, 2023
    Inventors: Neil P. DESAI, Gilles DIVITA
  • Peptides and nanoparticles for intracellular delivery of molecules
    Patent number: 11713336
    Abstract: The present invention pertains to peptides and peptide-containing complexes/nanoparticles that are useful for stabilizing and delivering cargo molecules such as nucleic acids.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: August 1, 2023
    Assignee: Aadigen, LLC
    Inventors: Gilles Divita, Neil Desai
  • COMPOSITIONS FOR TREATING CANCER WITH KRAS MUTATIONS AND USES THEREOF
    Publication number: 20230167437
    Abstract: The present application provides guide RNAs and genome-editing complexes or nanoparticles that are useful for specifically targeting a mutated KRAS. Exemplary genome-editing complexes or nanoparticles comprise cell-penetrating peptides, and optionally a DNA nuclease (such as Cas9) or a polynucleotide encoding the DNA nuclease.
    Type: Application
    Filed: April 23, 2021
    Publication date: June 1, 2023
    Inventors: Neil P. DESAI, Gilles DIVITA
  • PEPTIDES AND NANOPARTICLES FOR INTRACELLULAR DELIVERY OF MOLECULES
    Publication number: 20210032290
    Abstract: The present invention pertains to peptides and peptide-containing complexes/nanoparticles that are useful for stabilizing and delivering cargo molecules such as nucleic acids.
    Type: Application
    Filed: July 15, 2020
    Publication date: February 4, 2021
    Inventors: Gilles DIVITA, Neil DESAI
  • PEPTIDES AND NANOPARTICLES FOR INTRACELLULAR DELIVERY OF MRNA
    Publication number: 20200323964
    Abstract: The present invention pertains to peptide-containing complexes/nanoparticles that are useful for delivering into a cell one or more mRNA (such as therapeutic mRNA, e.g., mRNA encoding a tumor suppressor protein).
    Type: Application
    Filed: October 15, 2018
    Publication date: October 15, 2020
    Inventors: Neil DESAI, Gilles DIVITA
  • Peptides and nanoparticles for intracellular delivery of molecules
    Patent number: 10745440
    Abstract: The present invention pertains to peptides and peptide-containing complexes/nanoparticles that are useful for stabilizing and delivering cargo molecules such as nucleic acids.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: August 18, 2020
    Assignee: Aadigen, LLC
    Inventors: Gilles Divita, Neil Desai
  • Cell penetrating peptides for intracellular delivery of molecules
    Patent number: 10688194
    Abstract: A cell-penetrating peptide characterized in that it comprises an amino acid sequence X3X4X1X2X5X4X1X2X6X7X1X8X9X10X11X13 (SEQ ID No: 11), wherein X1 is F or W, X2 is F, W or Y, X3 is beta-A or S, X4 is K, R or L, X5 is E, R or S, X6 is R. T or S, X7 is E, R or S, X8 is none, F or W, X9 is P or R, X10 is R or L, X11 is K, W or R, X12 is R or F and X13 is R or K.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: June 23, 2020
    Assignee: Aadigen, LLC
    Inventors: Gilles Divita, Sebastien Deshayes, Karidia Konate, May Catherine Morris
  • PEPTIDES AND NANOPARTICLES FOR INTRACELLULAR DELIVERY OF VIRUS
    Publication number: 20200172913
    Abstract: The present invention pertains to peptide-containing complexes/nanoparticles that are useful for delivering into a cell one or more viruses (such as recombinant viruses, e.g., recombinant AAV) and/or masking antigenic epitopes on the one or more viruses.
    Type: Application
    Filed: August 9, 2018
    Publication date: June 4, 2020
    Inventors: Neil DESAI, Gilles DIVITA
  • Cell penetrating peptides for intracellular delivery of molecules
    Patent number: 10421784
    Abstract: A cell-penetrating peptide characterized in that it comprises an amino acid sequence: X1X2X3WWX4X5WAX6X3X7X8X9X10X11X12WX13R (SEQ ID No: 10), wherein X1, is beta-A or S, X2 is L or none, X3 is R or none, X4 is L, R or G, X5 is R, W or S, X6 is S, P or T, X7 is W or P, X8 is F, A or R, X9 is S, L, P or R, X10 is R or S, X11 n is W or none, X12 is A, R or none and X13 is W or F, and wherein if X3 is none, then X3, X11 and X12 are none as well.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: September 24, 2019
    Assignee: AADIGEN, LLC
    Inventors: Gilles Divita, Sebastien Deshayes, Karidia Konate, May Catherine Morris
  • PEPTIDES AND NANOPARTICLES FOR INTRACELLULAR DELIVERY OF GENOME-EDITING MOLECULES
    Publication number: 20190211317
    Abstract: The present invention pertains to peptide-containing complexes/nanoparticles that are useful for stabilizing and/or delivering one or more molecules of a genome-editing system, such as proteins and/or nucleic acids, for example CRISPR proteins and/or nucleic acids.
    Type: Application
    Filed: May 26, 2017
    Publication date: July 11, 2019
    Applicant: Aadigen, LLC
    Inventors: Gilles DIVITA, Neil DESAI
  • Cell penetrating peptides for intracellular delivery of molecules
    Patent number: 10287581
    Abstract: The present invention relates to a new family of cell-penetrating peptides, comprising an amino acid sequence X1LX2RALWRLX3RX4LWRLX5X6X7X8, wherein X1 is beta-A or S, X2 is F or W, X3 is L, W, C or I, X4 is S, A, N or T, X5 is L or W, X6 is W or R, X7 is K or R, and X8 is A or none. These peptides exhibit high efficiency, low toxicity and a natural tropism for lung tissues, and can be used either in simple complex with the cargo to be vectorised, or in nanoparticles comprising two layers of cell-penetrating peptides around the cargo.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: May 14, 2019
    Assignee: AADIGEN, LLC
    Inventors: Gilles Divita, Karidia Konate, May Catherine Morris, Sebastien Deshayes
  • CELL PENETRATING PEPTIDES FOR INTRACELLULAR DELIVERY OF MOLECULES
    Publication number: 20190077833
    Abstract: A cell-penetrating peptide characterized in that it comprises an amino acid sequence: X1X2X3WWX4X5WAX6X3X7X8X9X10X11X12WX13R (SEQ ID No: 10), wherein X1, is beta-A or S, X2 is L or none, X3 is R or none, X4 is L, R or G, X5 is R, W or S, X6 is S, P T, X7 is W or P, X8 is F, A or R, X9 is S, L, P or R, X10 is R or S, X11 n is W or none, X12 is A, R or none and X13 is W or F, and wherein if X3 is none, then X3, X11 and X12 are none as well.
    Type: Application
    Filed: March 20, 2017
    Publication date: March 14, 2019
    Inventors: Gilles DIVITA, Sebastien DESHAYES, Karidia KONATE, May Catherine MORRIS
  • CELL PENETRATING PEPTIDES FOR INTRACELLULAR DELIVERY OF MOLECULES
    Publication number: 20190046652
    Abstract: A cell-penetrating peptide characterized in that it comprises an amino acid sequence X3X4X1X2X5X4X1X2X6X7X1X8X9X10X11X13 (SEQ ID No: 1 1), wherein X1 is F or W, X2 is F, W or Y, X3 is beta-A or S, X4 is K, R or L, X5 is E, R or S, X6 is R. T or S, X7 is E, R or S, X8 is none, F or W, X9 is P or R, X10 is R or L, X11 is K, W or R, X12 is R or F and X13 is R or K.
    Type: Application
    Filed: October 26, 2018
    Publication date: February 14, 2019
    Inventors: Gilles DIVITA, Sebastien DESHAYES, Karidia KONATE, May Catherine MORRIS
  • Cell penetrating peptides for intracellular delivery of molecules
    Patent number: 10189876
    Abstract: A cell-penetrating peptide characterized in that it comprises an amino acid sequence consisting of XWXRLXXXXXX (SEQ ID No: 5), wherein X in position 1 is beta-A or S; X in positions 3, 9 and 10 are, independently from each other, W or F; X in position 6 is R if X in position 8 is S, and X in position 6 is S if X in position 8 is R; X in position 7 is L or none; X in position 11 is R or none, and wherein X in position 7 is L if X in position 11 is none.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: January 29, 2019
    Assignee: Aadigen, LLC
    Inventors: Gilles Divita, Sebastien Deshayes, Karidia Konate, May Catherine Morris
  • PEPTIDES AND NANOPARTICLES FOR INTRACELLULAR DELIVERY OF MOLECULES
    Publication number: 20190002499
    Abstract: The present invention pertains to peptides and peptide-containing complexes/nanoparticles that are useful for stabilizing and delivering cargo molecules such as nucleic acids.
    Type: Application
    Filed: December 23, 2015
    Publication date: January 3, 2019
    Inventors: Gilles DIVITA, Neil DESAI
  • Cell penetrating peptides for intracellular delivery of molecules
    Patent number: 10118944
    Abstract: A cell-penetrating peptide characterized in that it comprises an amino acid sequence consisting of a beta-alanine or a serine in N-terminal position, linked to a sequence consisting of 9 consecutive amino acids from the sequence RXWXRLWXRLR (SEQ ID NO:7), wherein X in position 2 is R or S and X in positions 4 and 8 are, independently from each other, W or F.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: November 6, 2018
    Assignee: Aadigen LLC
    Inventors: Gilles Divita, Sebastien Deshayes, Karidia Konate, May Catherine Morris
  • Cell penetrating peptides for intracellular delivery of molecules
    Patent number: 10111965
    Abstract: A cell-penetrating peptide characterized in that it comprises an amino acid sequence X3X4X1X2X5X4X1X2X6X7X1X8X9X10X11X12X13 (SEQ ID No: 11), wherein X1 is F or W, X2 is F, W or Y, X3 is beta-A or S, X4 is K, R or L, X5 is E, R or S, X6 is R. T or S, X7 is E, R or S, X8 is none, F or W, X9 is P or R, X10 is R or L, X11 is K, W or R, X12 is R or F and X13 is R or K.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: October 30, 2018
    Assignee: Aadigen, LLC
    Inventors: Gilles Divita, Sebastien Deshayes, Karidia Konate, May Catherine Morris
  • CELL PENETRATING PEPTIDES FOR INTRACELLULAR DELIVERY OF MOLECULES
    Publication number: 20180179253
    Abstract: A cell-penetrating peptide characterized in that it comprises an amino acid sequence consisting of XWXRLXXXXXX (SEQ ID No: 5), wherein X in position 1 is beta-A or S; X in positions 3, 9 and 10 are, independently from each other, W or F; X in position 6 is R if X in position 8 is S, and X in position 6 is S if X in position 8 is R; X in position 7 is L or none; X in position 11 is R or none, and wherein X in position 7 is L if X in position 11 is none.
    Type: Application
    Filed: November 2, 2017
    Publication date: June 28, 2018
    Inventors: Gilles DIVITA, Sebastien DESHAYES, Karidia KONATE, May Catherine MORRIS
  • Cell penetrating peptides for intracellular delivery of molecules
    Patent number: 9834581
    Abstract: A cell-penetrating peptide characterized in that it comprises an amino acid sequence consisting of XWXRLXXXXXX (SEQ ID No: 5), wherein X in position 1 is beta-A or S; X in positions 3, 9 and 10 are, independently from each other, W or F; X in position 6 is R if X in position 8 is S, and X in position 6 is S if X in position 8 is R; X in position 7 is L or none; X in position 11 is R or none, and wherein X in position 7 is L if X in position 11 is none.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: December 5, 2017
    Assignee: Aadigen LLC
    Inventors: Gilles Divita, Sebastien Deshayes, Karidia Konate, May Catherine Morris
  • CELL PENETRATING PEPTIDES FOR INTRACELLULAR DELIVERY OF MOLECULES
    Publication number: 20170258928
    Abstract: A cell-penetrating peptide characterized in that it comprises an amino acid sequence X3X4X1X2X5X4X1X2X6X7X1X8X9X10X11X12X13 (SEQ ID No: 11), wherein X1 is F or W, X2 is F, W or Y, X3 is beta-A or S, X4 is K, R or L, X5 is E, R or S, X6 is R. T or S, X7 is E, R or S, X8 is none, F or W, X9 is P or R, X10 is R or L, X11 is K, W or R, X12 is R or F and X13 is R or K.
    Type: Application
    Filed: February 9, 2017
    Publication date: September 14, 2017
    Inventors: Gilles DIVITA, Sebastien DESHAYES, Karidia KONATE, May Catherine MORRIS