Patents by Inventor Gilles H Michel

Gilles H Michel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lentiviral vectors for site-specific gene insertion
    Patent number: 7531647
    Abstract: Murine leukemia virus (MLV) and lentivirus vectors have been used previously to deliver genes to hematopoietic stem cells (HSCs) in human gene therapy trials. However, these vectors integrate randomly into the host genome, leading to disruption or inactivation of vital host genes. The present invention discloses a novel lentiviral vector system that overcomes this problem by integrating into a host genome in a site-specific manner.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: May 12, 2009
    Assignee: City of Hope
    Inventors: Jiing-Kuan Yee, Gilles H Michel
  • NOVEL LENTIVIRAL VECTORS FOR SITE-SPECIFIC GENE INSERTION
    Publication number: 20080200663
    Abstract: Murine leukemia virus (MLV) and lentivirus vectors have been used previously to deliver genes to hematopoietic stem cells (HSCs) in human gene therapy trials. However, these vectors integrate randomly into the host genome, leading to disruption or inactivation of vital host genes. The present invention discloses a novel lentiviral vector system that overcomes this problem by integrating into a host genome in a site-specific manner.
    Type: Application
    Filed: April 21, 2008
    Publication date: August 21, 2008
    Inventors: Jiing-Kuan Yee, Gilles H. Michel