Patents by Inventor Gilles Subra
Gilles Subra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240010610Abstract: The present invention relates to a compound of the following formula (I): in particular for use in a method for preventing or treating a disease in an individual, more particularly for preventing or treating a disease is associated to progerin or to prelamin A.Type: ApplicationFiled: November 24, 2021Publication date: January 11, 2024Inventors: Pierre CAU, Eric DESSAUD, Muriel AMBLARD-CAUSSIL, Pascal VERDIE, Gilles SUBRA, Alexandre DEFOUX, Claire NAVARRO, Sophie PERRIN
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Publication number: 20220267522Abstract: The present invention relates to new biopolymer, i.e. bioorganic nylons incorporating peptidic blocks obtained by a process of polymerization of amino peptidic blocks. The process of the invention comprises the steps of mixing amino peptidic blocks with or without a diaminoalcane and reacting the mixture according to polycondensation with a diacyl chloride in homogeneous or heterogeneous media.Type: ApplicationFiled: March 8, 2022Publication date: August 25, 2022Applicants: Universite De Montpellier, Centre National de la Recherche Scientifique (CNRS)Inventors: Jean Martinez, Ahmad Mehdi, Gilles Subra, Saïd Jebors
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Patent number: 11299590Abstract: The present invention relates to new biopolymer, i.e. bioorganic nylons incorporating peptidic blocks obtained by a process of polymerization of amino peptidic blocks. The process of the invention comprises the steps of mixing amino peptidic blocks with or without a diaminoalcane and reacting the mixture according to polycondensation with a diacyl chloride in homogeneous or heterogeneous media.Type: GrantFiled: December 9, 2016Date of Patent: April 12, 2022Inventors: Jean Martinez, Ahmad Mehdi, Gilles Subra, Saïd Jebors
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Publication number: 20210393855Abstract: The present invention relates to hydrogels prepared using silylated organic molecules (such as silylated biomolecules), a process for obtaining the same, and uses thereof.Type: ApplicationFiled: June 25, 2021Publication date: December 23, 2021Applicants: Universite de Montpellier, Centre National de la Recherche Scientifique (CNRS)Inventors: Jean Martinez, Ahmad Mehdi, Gilles Subra, Said Jebors, Cécile Echalier
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Publication number: 20190367670Abstract: The present invention relates to new biopolymer, i.e. bioorganic nylons incorporating peptidic blocks obtained by a process of polymerization of amino peptidic blocks. The process of the invention comprises the steps of mixing amino peptidic blocks with or without a diaminoalcane and reacting the mixture according to polycondensation with a diacyl chloride in homogeneous or heterogeneous media.Type: ApplicationFiled: December 9, 2016Publication date: December 5, 2019Applicants: Universite De Montpellier, Centre National de la Recherche Scientifique (CNRS)Inventors: Jean Martinez, Ahmad Mehdi, Gilles Subra, Saïd Jebors
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Publication number: 20180200408Abstract: The present invention relates to hydrogels prepared using silylated organic molecules (such as silylated biomolecules), a method for obtaining same, and uses thereof.Type: ApplicationFiled: July 7, 2016Publication date: July 19, 2018Applicants: Universite de Montpellier, Centre National de la Recherche Scientifique (CNRS)Inventors: Jean Martinez, Ahmad Mehdi, Gilles Subra, Said Jebors, Cécile Echalier
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Publication number: 20170239237Abstract: This invention concerns pyrroloquinoline derivatives as antagonists of 5-HT6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in schizophrenia, anxiety, depression, maniac depression, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, panic attacks, attention deficit hyperactivity disorder, attention deficit disorder, Parkinson's disease, Huntington's disease, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, obesity and type-2 diabetes, functional bowel disorder, Irritable Bowel Syndrome. The compounds have the general formula (XIV), wherein the symbols have the meanings given in the description.Type: ApplicationFiled: May 5, 2017Publication date: August 24, 2017Inventors: Pawel ZAJDEL, Katarzyna GRYCHOWSKA, Maciej PAWLOWSKI, Anna PARTYKA, Anna WESOLOWSKA, Andrzej J. BOJARSKI, Piotr POPIK, Tomasz KOS, Grzegorz SATALA, Frederic LAMATY, Evelina COLACINO, Jean MARTINEZ, Gilles SUBRA, Xavier BANTREIL
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Patent number: 9676772Abstract: This invention concerns pyrroloquinoline derivatives as antagonists of 5-HT6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in schizophrenia, anxiety, depression, maniac depression, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, panic attacks, attention deficit hyperactivity disorder, attention deficit disorder, Parkinson's disease, Huntington's disease, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, obesity and type-2 diabetes, functional bowel disorder, Irritable Bowel Syndrome. The compounds have the general formula (XIV), wherein the symbols have the meanings given in the description.Type: GrantFiled: July 25, 2013Date of Patent: June 13, 2017Assignees: Uniwersyter Jagiellonski, Instytut Farmakologii Polskiej Akademii Nauk, Centre National De La Recherche Scientifique, Universite de MontpellierInventors: Pawel Zajdel, Katarzyna Grychowska, Maciej Pawlowski, Anna Partyka, Anna Wesolowska, Andrzej J. Bojarski, Piotr Popik, Tomasz Kos, Grzegorz Satala, Frederic Lamaty, Evelina Colacino, Jean Martinez, Gilles Subra, Xavier Bantreil
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Publication number: 20160096865Abstract: The invention relates to novel peptide-silane “hybrid block” molecules, to the synthesis thereof and to the use of same for producing novel peptide-silica hybrid materials that can be used in various applications.Type: ApplicationFiled: June 24, 2013Publication date: April 7, 2016Applicant: Universite de Montpellier IInventors: Jean MARTINEZ, Gilles SUBRA, Ahmad MEHDI, Said JEBORS, Christine ENJALBAL, Luc BRUNEL, Francois FAJULA
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Patent number: 8546533Abstract: The present invention relates to a pipecolic linker and its use as a solid-phase linker in organic synthesis. Said pipecolic solid-phase linker may be used for coupling functional groups chosen between primary amines, secondary amines, aromatic amines, alcohols, phenols and thiols. In particular, said pipecolic solid-phase linker may be used for peptide or pseudopeptide synthesis, such as the reverse N to C peptide synthesis or the retro-inverso peptide synthesis, or for the synthesis of small organic molecules.Type: GrantFiled: August 28, 2009Date of Patent: October 1, 2013Assignees: Centre National de la Recherche Scientifique (CNRS), Universite de Montpellier 1, Universite Jagellone, Universite Montpellier 2—Sciences et TechniquesInventors: Jean Martinez, Pawel Zajdel, Maciej Pawlowski, Gilles Subra
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Publication number: 20120070856Abstract: The invention relates to a protein cross-linking agent of the formula, where R1 is an aryl group optionally substituted once or several times by a grouping selected from the group consisting of hydroxy, C1-C4 alkyl, OBoc, SO3Na, Deu, and C1-C4 alkoxy groupings, R2 is N, (III), or (IV), n and in are identical or different integers between 0 and 10, p is an integer between 0 and 5, k is 0, 1, 2 or 3, and X and X? are identical or different and are a reactive function of the proteins. The invention also relates to a method for the structural analysis of a protein or a protein complex.Type: ApplicationFiled: March 4, 2010Publication date: March 22, 2012Inventors: Jean Martinez, Gilles Subra, Christine Goubet, David Paramelle, Eric Forest, Michaël Heymann, Christophe Geourjon
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Patent number: 8097590Abstract: The invention relates to a dipeptide conjugate having general formula I, AA2-AA1-NH2, wherein A represent the radical corresponding to a monocarboxylic acid with general formula II, HOOC—R, in which: R represents a linear or branched aliphatic radical at C1-C24, which is optionally substituted by a hydroxyl group and which can comprise one or more unsaturations, preferably between 1 and 6 unsaturations, and/or which can comprise a phenyl group or lipoic acid or the reduced form thereof, dihydrolipoic acid or N-lipoyllysine; and AA1 and AA2 represent identical or different amino acids which are selected from the group containing Ala, Asn, Cys, Gln, Gly, Ile, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Asp, Glu, Arg, His, Lys, Orn, Dap, Dab, the corresponding homo-amino acids and the corresponding beta-amino acids in the form of enantiomers or diastereoisomers and mixtures thereof, including racemic mixtures.Type: GrantFiled: May 10, 2005Date of Patent: January 17, 2012Assignees: Centre National de la Recherche Scientifique (CNRS), Institut Europeen de Biologie Cellulaire, Universite de Montpellier I, Universite de Montpellier IIInventors: Anne-Marie Pinel, Pascal Verdie, Pascaline Dubs, Jean Martinez, Gilles Subra
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Patent number: 8017581Abstract: The invention relates to a tripeptide conjugate having general formula I, A-AA1-AA2-AA3-NH2, wherein A represents the radical corresponding to a monocarboxylic acid with general formula II, HOOC—R, in which: R represents a linear or branched aliphatic radical at C1-C24, which is optionally substituted by a hydroxyl group and which can comprise one or more unsaturations, preferably between 1 and 6 unsaturations, lipoic acid or the reduced form thereof, dihydrolipoic acid, N-lipoyllysine, or phenylbutyric acid; and AA1, AA2 and AA3, which may be identical or different, represent independently of each other an amino acid selected from His, Phe, Ala, Arg, Lys, Orn, Trp, Nap, Tpi and Tic, on the condition that at least one of AA1, AA2 or AA3 represent Phe, preferably Dphe in the form of enantiomers or diastereoisomers and mixtures thereof, including racemic mixtures.Type: GrantFiled: May 10, 2005Date of Patent: September 13, 2011Assignees: Centre National de la Recherche Scientifique (CNRS), Institut Europeen de Biologie Cellulaire, Universite de Montpellier I, Universite Montpellier IIInventors: Jean Martinez, Pascal Verdie, Pascaline Dubs, Anne-Marie Pinel, Gilles Subra
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Publication number: 20110152464Abstract: The present invention relates to a pipecolic linker and its use as a solid-phase linker in organic synthesis. Said pipecolic solid-phase linker may be used for coupling functional groups chosen between primary amines, secondary amines, aromatic amines, alcohols, phenols and thiols. In particular, said pipecolic solid-phase linker may be used for peptide or pseudopeptide synthesis, such as the reverse N to C peptide synthesis or the retro-inverso peptide synthesis, or for the synthesis of small organic molecules.Type: ApplicationFiled: August 28, 2009Publication date: June 23, 2011Applicant: UNIVERSITE DE MONTPELLIER IInventors: Jean Martinez, Pawel Zajdel, Maciej Pawlowski, Gilles Subra
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Publication number: 20110003943Abstract: The present invention relates to a supported oxidation reactant of formula (I): R-[Met(O)k]n-X-(I) in which: —R represents a hydrogen atom or an amine function-protecting group, —[Met(O)] represents an oxidized methionine residue of formula—k is 1 or 2—represents a solid or soluble support used in organic synthesis, —X represents a radical derived from a function of the type amine or hydroxyl, or halogeno, capable of anchoring methionine, it being understood that this function capable of anchoring methionine can be separated from the support by means of a functionalized arm or a spacer, and—n is an integer greater than or equal to 1. The invention also relates to the use of a supported oxidation reactant of formula (I), for the formation of intramolecular disulfide bridges, in particular in peptides and/or proteins.Type: ApplicationFiled: June 14, 2007Publication date: January 6, 2011Applicants: Centre National de la Recherche Scientifique (CNRS, Universite de Montpellier l, GenepepInventors: Jean Martinez, Gilles Subra, Michèle Cristau, Sonia Cantel
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Patent number: 7785577Abstract: The invention relates to a peptide of formula W-DPhe-Arg-Z (I) and to a conjugate thereof of a formula A-W-DPhe-Arg-Z (II), wherein A is a radical corresponding to a monocarboxylic acid of general formula HOOC—R (III), wherein R is an linear or branched possibly substituted by a hydroxy group aliphatic C1-C24 radical which can comprise one or several unsaturations, preferably from 1 to 6 unsaturations, a lipoic acid or the reduced form thereof, a dihydrolipoic acid, N-lipoyl-lysine or a phenylbutyric acid, W is His, Ala-His, Ala-Ala-His, Nle-Ala-His, DTrp-Ala-His, Nle-Trp-His, Lys, Ala-Lys, Nle-Ala-Lys, Orn, Ala-Orn, Nle-Ala-Orn, Ala, Nle-Ala-Ala, Arg, Ala-Arg.Type: GrantFiled: May 10, 2005Date of Patent: August 31, 2010Assignees: Institut Europeen de Biologie Cellulaiare, Centre National de la Recherche Scientifique (CNRS), Universite de Montpellier I, Universite de Montpellier IIInventors: Michel Hocquaux, Anne-Marie Pinel, Jean Martinez, Gilles Subra
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Publication number: 20080200396Abstract: The invention relates to a peptide of formula W-DPhe-Arg-Z (I) and to a conjugate thereof of a formula A-W-DPhe-Arg-Z (II), wherein A is a radical corresponding to a nionocarboxylic acid of general formula HOOC—R (III), wherein R is an linear or branched possibly substituted by a hydroxy group aliphatic C1-C24 radical which can comprise one or several unsaturations, preferably from 1 to 6 unsaturations, a lipoic acid or the reduced form thereof, a dihydrolipoic acid, N-lipoyl-lysine or a phenylbutyric acid, W is His, Ala-His, Ala-Ala-His, Nle-Ala-His, DTrp-Ala-His, Nle-Trp-His, Lys, Ala-Lys, Nle-Ala-Lys, Orn, Ala-Orn, Nle-Ala-Orn, Ala, Nle-Ala-Ala, Arg, Ala-Arg.Type: ApplicationFiled: May 10, 2005Publication date: August 21, 2008Applicants: INSTITUT EUROPEN DE BIOLOGIE CELLULAIRE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS, UNIVERSITE DE MONTPELLIER I, UNIVERSITE MONTPELLIER IIInventors: Michel Hocquaux, Anne-Marie Pinel, Jean Martinez, Gilles Subra
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Publication number: 20070231284Abstract: The invention relates to a dipeptide conjugate having general formula I, AA2-AA1-NH2, wherein A represent the radical corresponding to a monocarboxylic acid with general formula II, HOOC—R, in which: R represents a linear or branched aliphatic radical at C1-C24, which is optionally substituted by a hydroxyl group and which can comprise one or more unsaturations, preferably between 1 and 6 unsaturations, and/or which can comprise a phenyl group or lipoic acid or the reduced form thereof, dihydrolipoic acid or N-lipoyllysine; and AA1 and AA2 represent identical or different amino acids which are selected from the group containing Ala, Asn, Cys, Gln, Gly, Ile, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Asp, Glu, Arg, His, Lys, Orn, Dap, Dab, the corresponding homo-amino acids and the corresponding beta-amino acids in the form of enantiomers or diastereoisomers and mixtures thereof, including racemic mixtures.Type: ApplicationFiled: May 10, 2005Publication date: October 4, 2007Inventors: Anne-Marie Pinel, Pascal Verdie, Pascaline Dubs, Jean Martinez, Gilles Subra