Patents by Inventor Gillian Einstein

Gillian Einstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Relation of apolipoprotein E genotype and estrogen deprivation in alzheimer's disease
    Publication number: 20020192725
    Abstract: A method of screening a subject for risk of developing Alzheimer's disease comprises determining the presence of at least one ApoE4 allele in a subject, and determining the presence or absence of decreased estrogen levels in said subject (e.g., due to previous or impending menopause or hysterectomy). The presence of at least one ApoE4 allele (and particularly two ApoE4 alleles) in combination with decreased estrogen levels in said subject indicating said subject is at greater risk of developing Alzheimer's disease (e.g., as compared to subjects with at corresponding number of ApoE4 alleles, but who do not have decreased estrogen levels), and that the subject will receive greater benefit from estrogen replacement therapy in treating Alzheimer's disease than a subject who does not carry one or two ApoE4 alleles.
    Type: Application
    Filed: June 26, 2002
    Publication date: December 19, 2002
    Inventors: Gillian Einstein, Laura W. Shaughnessy, Donald E. Schmechel
  • Method of determining Alzheimer's disease risk using apolipoprotein E4 genotype analysis in combination with decreased estrogen levels
    Patent number: 6432643
    Abstract: A method of screening a subject for risk of developing Alzheimer's disease is carried out by determining the presence of at least one ApoE4 allele in a subject, and determining the presence or absence of decreased estrogen levels in the subject (e.g., due to previous or impending menopause or hysterectomy). The presence of at least one ApoE4 allele (and particularly two ApoE4 alleles) in combination with decreased estrogen levels in the subject indicating the subject is at greater risk of developing Alzheimer's disease (e.g., as compared to subjects with at corresponding number of ApoE4 alleles, but who do not have decreased estrogen levels), and that the subject will receive greater benefit from estrogen replacement therapy in treating Alzheimer's disease than a subject who does not carry one or two ApoE4 alleles.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: August 13, 2002
    Assignee: Duke University
    Inventors: Gillian Einstein, Laura W. Shaughnessy, Donald E. Schmechel
  • METHOD OF DETERMINING ALZHEIMER'S DISEASE RISK USING APOLIPOPROTEIN E4 GENOTYPE ANALYSIS IN COMBINATION WITH DECREASED ESTROGEN LEVELS
    Publication number: 20020098481
    Abstract: A method of screening a subject for risk of developing Alzheimer's disease comprises determining the presence of at least one ApoE4 allele in a subject, and determining the presence or absence of decreased estrogen levels in said subject (e.g., due to previous or impending menopause or hysterectomy). The presence of at least one ApoE4 allele (and particularly two ApoE4 alleles) in combination with decreased estrogen levels in said subject indicating said subject is at greater risk of developing Alzheimer's disease (e.g., as compared to subjects with at corresponding number of ApoE4 alleles, but who do not have decreased estrogen levels), and that the subject will receive greater benefit from estrogen replacement therapy in treating Alzheimer's disease than a subject who does not carry one or two ApoE4 alleles.
    Type: Application
    Filed: October 22, 1999
    Publication date: July 25, 2002
    Inventors: GILLIAN EINSTEIN, LAURA W. SHAUGHNESSY, DONALD E. SCHMECHEL