Patents by Inventor Gillie A. ROTH

Gillie A. ROTH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TOLL-LIKE RECEPTOR (TLR) AGONIST NANOPARTICLES AND USES THEREOF
    Publication number: 20230173059
    Abstract: The present disclosure provides nanoparticles comprising a polymer and a plurality of TLR agonist moieties conjugated to the polymer and present on the surface of the nanoparticles. Methods of producing the nanoparticles, hydrogels comprising the nanoparticles, and vaccines comprising the nanoparticles and/or hydrogels are also provided. Methods for inducing an antigen-specific humoral immune response or enhancing cancer immunotherapy in a subject are also provided.
    Type: Application
    Filed: May 14, 2021
    Publication date: June 8, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eric A. Appel, Emily C. Gale, Anton A. A. Smith, Gillie A. Roth, Vittoria C.T.M. Picece
  • INJECTABLE HYDROGELS FOR CONTROLLED RELEASE OF IMMUNOMODULATORY COMPOUNDS
    Publication number: 20210338801
    Abstract: An immunomodulatory delivery system includes a hydrogel, a first immunomodulatory cargo encapsulated in the cargo, and a second immunomodulatory cargo encapsulated in the hydrogel. The hydrogel includes a polymer non-covalently crossed-linked with a plurality of nanoparticles. The first immunomodulatory cargo is smaller than the second immunomodulatory cargo. A ratio of a diffusivity of the first immunomodulatory cargo through the hydrogel to a diffusivity of the second immunomodulatory cargo through the hydrogel is less than 3.
    Type: Application
    Filed: October 1, 2019
    Publication date: November 4, 2021
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Gillie A. ROTH, Eric Andrew APPEL, Mark DAVIS, Emily C. GALE, Santiago CORREA