Abstract: A system and method for generating a decision tree having a plurality of nodes, arranged hierarchically as parent nodes and child nodes, comprising: generating a node including: receiving i) training data including data instances, each data instance having a plurality of attributes and a corresponding label, ii) instance weightings, iii) a valid domain for each attribute generated, and iv) an accumulated weighted sum of predictions for a branch of the decision tree; and associating one of a plurality of binary prediction of an attribute with each node including selecting the one of the plurality of binary predictions having a least amount of error; in accordance with a determination that the node includes child nodes, repeat the generating the node step for the child nodes; and in accordance with a determination that the node is a terminal node, associating the terminal node with an outcome classifier; and displaying the decision tree including the plurality of nodes arranged hierarchically.

Abstract: A method comprises receiving one or more plan parameters of a first radiation treatment plan for a first patient and one or more passing rate data for the first treatment plan; generating a predictive model for passing rate data from the plan parameters of the first radiation treatment plan and the passing rate data for the first treatment plan; receiving one or more plan parameters of a second radiation treatment plan for a second patient; and applying the predictive model to the plan parameters of the second radiation treatment to generate one or more predicted passing rate data for the plan parameters for the second patient.

Abstract: A method comprises receiving one or more plan parameters of a first radiation treatment plan for a first patient and one or more passing rate data for the first treatment plan; generating a predictive model for passing rate data from the plan parameters of the first radiation treatment plan and the passing rate data for the first treatment plan; receiving one or more plan parameters of a second radiation treatment plan for a second patient; and applying the predictive model to the plan parameters of the second radiation treatment to generate one or more predicted passing rate data for the plan parameters for the second patient.

Abstract: Systems and methods for enhancing the selective targeting of agents for preferential action at a target with reduced action with healthy tissue distal the target tissue. One or more agents can be combined with nano scale structures/particles for delivery to the target tissue. Appropriate bombardment with accelerated particle radiation, such as proton radiation, induces the release of the agents at the target site. Nano carriers can be combined with therapeutic and/or imaging enhancement agents. Imaging of the target tissue can provide a verification of the delivered dose of particle radiation. Nanocarriers can be provided with an outer shell selected for biocompatibility and durability in the in vivo environment and further selected to provide a feedback mechanism in the treatment environment to accelerate the release of the agent and reduce a total radiation dose needed for that release.

Abstract: Systems and methods for enhancing the selective targeting of agents for preferential action at a target with reduced action with healthy tissue distal the target tissue. One or more agents can be combined with nano scale structures/particles for delivery to the target tissue. Appropriate bombardment with accelerated particle radiation, such as proton radiation, induces the release of the agents at the target site. Nano carriers can be combined with therapeutic and/or imaging enhancement agents. Imaging of the target tissue can provide a verification of the delivered dose of particle radiation. Nanocarriers can be provided with an outer shell selected for biocompatibility and durability in the in vivo environment and further selected to provide a feedback mechanism in the treatment environment to accelerate the release of the agent and reduce a total radiation dose needed for that release.

Abstract: Systems and methods for enhancing the selective targeting of agents for preferential action at a target with reduced action with healthy tissue distal the target tissue. One or more agents can be combined with nano scale structures/particles for delivery to the target tissue. Appropriate bombardment with accelerated particle radiation, such as proton radiation, induces the release of the agents at the target site. Nano carriers can be combined with therapeutic and/or imaging enhancement agents. Imaging of the target tissue can provide a verification of the delivered dose of particle radiation. Nanocarriers can be provided with an outer shell selected for biocompatibility and durability in the in vivo environment and further selected to provide a feedback mechanism in the treatment environment to accelerate the release of the agent and reduce a total radiation dose needed for that release.