Patents by Inventor Gina Chia Yi Chu

Gina Chia Yi Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods to sensitize cancer cells to tyrosine kinase inhibitors
    Patent number: 11878000
    Abstract: The present invention generally relates to sensitizer compounds and their use in combination with Tyrosine Kinase Inhibitors (TKIs) for sensitizing tumor, cancer or pre-cancerous cells to TKI treatment. In particular, the present invention relates to administration regimes that combine TKIs such as Gefitinib or Icotinib with TKI-sensitizing DZ1 esters and amides conjugated to statin or platin-based drugs, or to Artemisinin, including, without limitation: DZ1-Simvastatin amide, DZ1-Simvastatin ester, DZ1-Cisplatin ester, and DZ1-Cisplatin amide, DZ1-Artemisinin ester, and DZ1-Artemisinin amide. Furthermore, the present invention relates to improved TKI treatment of cancers by sensitizing tumor, cancer or pre-cancerous cells, in particular cancers that develop TKI resistance, including e.g. lung cancer and pancreatic cancer.
    Type: Grant
    Filed: October 21, 2017
    Date of Patent: January 23, 2024
    Assignees: Da Zen Theranostics, Inc., Cedars-Sinai Medical Center
    Inventors: Liyuan Yin, Yi Zhang, Stefan Mrdenovic, Gina Chia Yi Chu, Ruoxiang Wang, Qinghua Zhou, Jian Zhang, Leland W. K. Chung