Patents by Inventor GINA MARIE ZASTROW-HAYES

GINA MARIE ZASTROW-HAYES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF IDENTIFYING AND CHARACTERIZING GENE EDITING VARIATIONS IN NUCLEIC ACIDS
    Publication number: 20230257799
    Abstract: Compositions and methods of identifying and characterizing potential gene editing on-target and off-target sites and/or edits in a nucleic acid are provided.
    Type: Application
    Filed: April 21, 2023
    Publication date: August 17, 2023
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARY BEATTY, NICHOLAS DOANE CHILCOAT, STEPHANE DESCHAMPS, GREGORY D MAY, GINA MARIE ZASTROW-HAYES
  • Methods for characterizing DNA sequence composition in a genome
    Patent number: 11702685
    Abstract: Methods for the high-throughput analysis of transgenic events are herein disclosed. The methods use libraries of sheared genomic DNA ligated to specialized adapters and pooled for sequence analysis and comparison to known genomic and insert sequence. The method finds use in detecting characterizing insertion site, transgene integrity, and transgene copy number.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: July 18, 2023
    Inventors: Mary Beatty, Kevin Hayes, Jenna Hoffman, Haining Lin, Gina Marie Zastrow-Hayes
  • ALTERATION OF SEED COMPOSITION IN PLANTS
    Publication number: 20230220409
    Abstract: Provided are compositions comprising polynucleotides encoding modified MFT polypeptides. Also provided are recombinant DNA constructs, plants, plant cells, seed, and grain comprising the polynucleotides. Additionally, methods using the polynucleotides in plants to increase seed oil and/or protein content are also provided herein.
    Type: Application
    Filed: June 2, 2021
    Publication date: July 13, 2023
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: JANEL M BETTIS, JOHN D EVERARD, KRISTIN HAUG COLLET, ZHAN-BIN LU, BO SHEN, SHREEDHARAN SRIRAM, YANG WANG, GINA MARIE ZASTROW-HAYES
  • Methods of identifying and characterizing gene editing variations in nucleic acids
    Patent number: 11661624
    Abstract: Compositions and methods of identifying and characterizing potential gene editing on-target and off-target sites and/or edits in a nucleic acid are provided.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: May 30, 2023
    Inventors: Mary Beatty, Nicholas Doane Chilcoat, Stephane Deschamps, Gregory D May, Gina Marie Zastrow-Hayes
  • METHODS FOR CHARACTERIZING DNA SEQUENCE COMPOSITION IN A GENOME
    Publication number: 20210238651
    Abstract: Methods for the high-throughput analysis of transgenic events are herein disclosed. The methods use libraries of sheared genomic DNA ligated to specialized adapters and pooled for sequence analysis and comparison to known genomic and insert sequence. The method finds use in detecting characterizing insertion site, transgene integrity, and transgene copy number.
    Type: Application
    Filed: February 8, 2021
    Publication date: August 5, 2021
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARY BEATTY, KEVIN HAYES, JENNA HOFFMAN, HAINING LIN, GINA MARIE ZASTROW-HAYES
  • SYSTEMS AND METHODS FOR EDITING A PLANT GENOME
    Publication number: 20210207153
    Abstract: Systems and methods for editing plant genomes include systems and methods for transforming plants generally, and Brassica plants particularly, with genome editing systems including CRISPR-Cas. Systems and methods for editing plant genomes include systems and methods for transforming Brassica microspores with genome editing systems and culturing the plant microspores that increase genome editing frequency.
    Type: Application
    Filed: May 30, 2019
    Publication date: July 8, 2021
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: David George Charne, Wenpin Chen, James Brent Gillespie, Siva S. Ammirajo Jetty, Zhan-Bin Liu, Gina Marie Zastrow-Hayes
  • Methods for characterizing DNA sequence composition in a genome
    Patent number: 10941436
    Abstract: Methods for the high-throughput analysis of transgenic events are herein disclosed. The methods use libraries of sheared genomic DNA ligated to specialized adapters and pooled for sequence analysis and comparison to known genomic and insert sequence. The method finds use in detecting characterizing insertion site, transgene integrity, and transgene copy number.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: March 9, 2021
    Inventors: Mary Beatty, Kevin Hayes, Jenna Hoffman, Haining Lin, Gina Marie Zastrow-Hayes
  • Detection of sequences uniquely associated with a dna target region
    Patent number: 10927409
    Abstract: The disclosed embodiments concern methods for determining sequences of interest using targeted unique molecular index (TUMI) sequences that are uniquely associated with individual polynucleotide fragments in plants, such as those present in a transgenic event, a site-specific mutation or a wild type variant. System, apparatus, and computer program products are also provided for determining a sequence of interest implementing the methods disclosed.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: February 23, 2021
    Inventors: Ananta Acharya, Amanda Gannon, Hena Guo, Kevin Hayes, Robyn Lynn Laskowski, Robert Ebow McEwan, Lasantha Ubayasena, Gina Marie Zastrow-Hayes
  • METHODS OF IDENTIFYING AND CHARACTERIZING GENE EDITING VARIATIONS IN NUCLEIC ACIDS
    Publication number: 20200040378
    Abstract: Compositions and methods of identifying and characterizing potential gene editing on-target and off-target sites and/or edits in a nucleic acid are provided.
    Type: Application
    Filed: March 29, 2018
    Publication date: February 6, 2020
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARY BEATTY, NICHOLAS DOANE CHILCOAT, STEPHANE DESCHAMPS, GREGORY D MAY, GINA MARIE ZASTROW-HAYES
  • METHODS FOR CHARACTERIZING DNA SEQUENCE COMPOSITION IN A GENOME
    Publication number: 20200032320
    Abstract: Methods for the high-throughput analysis of transgenic events are herein disclosed. The methods use libraries of sheared genomic DNA ligated to specialized adapters and pooled for sequence analysis and comparison to known genomic and insert sequence. The method finds use in detecting characterizing insertion site, transgene integrity, and transgene copy number.
    Type: Application
    Filed: October 10, 2019
    Publication date: January 30, 2020
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARY BEATTY, KEVIN HAYES, JENNA HOFFMAN, HAINING LIN, GINA MARIE ZASTROW-HAYES