Patents by Inventor Gina McLaren
Gina McLaren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7783098Abstract: A method including acquiring images of medical slides at a plurality of different focus positions, determining a position which produces a maximum value of pixel values relative to a pixel value mean, wherein said determining comprises using a pixel value mean as a coarse estimate of coarse focus position, and subsequently refining said coarse focus position to find a fine focus position, and wherein said refining comprises fitting to a polynomial, and using a specified portion of the polynomial as a fine estimate of focus position, and producing a focus control signal that is related to said maximum value to control a focus position.Type: GrantFiled: August 29, 2008Date of Patent: August 24, 2010Assignee: Carl Zeiss MicroImaging GmbHInventors: James W. Douglass, Thomas J. Riding, James E. Ring, Gina McLaren, William J. Decker, Robert T. Ellis
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Patent number: 7558415Abstract: A method, system, and apparatus are provided for automated light microscopic for detection of proteins associated with cell proliferative disorders.Type: GrantFiled: February 13, 2007Date of Patent: July 7, 2009Assignee: Carl Zeiss MicroImaging AIS, Inc.Inventors: Gina McLaren, Robert Ellis, James W. Douglass, Thomas J. Riding, James E. Ring
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Publication number: 20090060303Abstract: A method including acquiring images of medical slides at a plurality of different focus positions, determining a position which produces a maximum value of pixel values relative to a pixel value mean, wherein said determining comprises using a pixel value mean as a coarse estimate of coarse focus position, and subsequently refining said coarse focus position to find a fine focus position, and wherein said refining comprises fitting to a polynomial, and using a specified portion of the polynomial as a fine estimate of focus position, and producing a focus control signal that is related to said maximum value to control a focus position.Type: ApplicationFiled: August 29, 2008Publication date: March 5, 2009Applicant: Carl Zeiss Microlmaging AIS, Inc.Inventors: James W. Douglass, Thomas J. Riding, James E. Ring, Gina McLaren, William J. Decker, Robert T. Ellis
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Patent number: 7428325Abstract: A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space. The color space converted image is then filtered. The candidate interest pixels are morphologically processed and compared to blob parameters to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification.Type: GrantFiled: March 13, 2007Date of Patent: September 23, 2008Assignee: Carl Zeiss MicroImaging AIS, Inc.Inventors: James W. Douglass, Thomas J. Riding, James E. Ring, Gina McLaren, William J. Decker, Robert T. Ellis
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Publication number: 20070206843Abstract: A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space. The color space converted image is then filtered. The candidate interest pixels are morphologically processed and compared to blob parameters to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification.Type: ApplicationFiled: March 13, 2007Publication date: September 6, 2007Inventors: James Douglass, Thomas Riding, James Ring, Gina McLaren, William Decker, Robert Ellis
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Publication number: 20070140540Abstract: A method, system, and apparatus are provided for automated light microscopic for detection of proteins associated with cell proliferative disorders.Type: ApplicationFiled: February 13, 2007Publication date: June 21, 2007Inventors: Gina McLaren, Robert Ellis, James Douglass, Thomas Riding, James Ring
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Patent number: 7190818Abstract: A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images (288) which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space (290). The color space converted image is then low pass filtered (292) and compared to a threshold (294) to remove artifacts and background objects from the candidate object of interest pixels of the color converted image. The candidate object of interest pixels are morphologically processed (296) to group candidate object of interest pixels together into groups which are compared to blob parameters (298) to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification.Type: GrantFiled: December 24, 2003Date of Patent: March 13, 2007Assignee: Clarient, Inc.Inventors: Bob Ellis, William J. Decker, Gina McLaren
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Patent number: 7177454Abstract: A method, system, and apparatus are provided for automated light microscopic for detection of proteins associated with cell proliferative disorders.Type: GrantFiled: February 3, 2003Date of Patent: February 13, 2007Assignee: Clarient, Inc.Inventors: Gina McLaren, Robert Ellis, James W. Douglass, Thomas J. Riding, James E. Ring
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Publication number: 20060080181Abstract: Provided is a system for and method of generating sales proposals and contracts. The system comprises a computer, including a proposal generator program, a local sales policy file, and an unspecified number of sales proposals; a second computer, including a contract generator program, a master sales policy file, and an unspecified number of sales contracts; a communication network and a customer information database. A sales policy file can be downloaded. After negotiating with a customer, the system generates a proposal, determines whether the proposal is accepted by the customer, sends the proposal to a home office, determines whether the proposal is accepted by a manager, generates a contract, and updates a customer information database.Type: ApplicationFiled: October 12, 2004Publication date: April 13, 2006Inventors: Curtis Fernandes, Gina McLaren, Robert Ellis
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Publication number: 20050283414Abstract: The disclosure is a system for and method of performing automated billing and other client-related activities on a remote computer system.Type: ApplicationFiled: October 20, 2004Publication date: December 22, 2005Inventors: Curtis Fernandes, Gina McLaren, Roger Johnson, Cindy Mason
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Patent number: 6947583Abstract: A method for automated image analysis of a biological specimen by histological reconstruction. Also provided is an automated cell image method for analyzing a biological specimen that has consecutively been stained by either an in situ hybridization (ISH) method, or an immunohistochemistry (IHC) method or a nucleic acid stain, and counterstained. The method couples composite images in an automated manner for processing and analysis. To identify structure in tissue that cannot be captured in a single field of view image or a single staining technique, the disclosure provides a method for histological reconstruction to analyze many fields of view on potentially many slides simultaneously.Type: GrantFiled: October 3, 2003Date of Patent: September 20, 2005Assignee: Clarient, Inc.Inventors: Bob Ellis, William J. Decker, Gina McLaren
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Publication number: 20040136581Abstract: A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images (288) which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space (290). The color space converted image is then low pass filtered (292) and compared to a threshold (294) to remove artifacts and background objects from the candidate object of interest pixels of the color converted image. The candidate object of interest pixels are morphologically processed (296) to group candidate object of interest pixels together into groups which are compared to blob parameters (298) to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification.Type: ApplicationFiled: December 24, 2003Publication date: July 15, 2004Applicant: Chroma Vision Medical Systems, Inc., a California corporationInventors: Bob Ellis, William J. Decker, Gina McLaren
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Publication number: 20040071327Abstract: A method for automated image analysis of a biological specimen by histological reconstruction. Also provided is an automated cell image method for analyzing a biological specimen that has consecutively been stained by either an in situ hybridization (ISH) method, or an immunohistochemistry (IHC) method or a nucleic acid stain, and counterstained. The method couples composite images in an automated manner for processing and analysis. To identify structure in tissue that cannot be captured in a single field of view image or a single staining technique, the disclosure provides a method for histological reconstruction to analyze many fields of view on potentially many slides simultaneously.Type: ApplicationFiled: October 3, 2003Publication date: April 15, 2004Applicant: ChromaVision Medical Systems, Inc., a California corporationInventors: Bob Ellis, William J. Decker, Gina McLaren
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Publication number: 20040066960Abstract: A method, system, and apparatus are provided for automated light microscopic for detection of proteins associated with cell proliferative disorders.Type: ApplicationFiled: February 3, 2003Publication date: April 8, 2004Applicant: ChromaVision Medical Systems, Inc., a California corporationInventors: Gina McLaren, Robert Ellis, James W. Douglass, Thomas J. Riding, James E. Ring
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Patent number: 6718053Abstract: A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images (288) which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space (290). The color space converted image is then low pass filtered (292) and compared to a threshold (294) to remove artifacts and background objects from the candidate object of interest pixels of the color converted image. The candidate object of interest pixels are morphologically processed (296) to group candidate object of interest pixels together into groups which are compared to blob parameters (298) to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification.Type: GrantFiled: February 1, 2000Date of Patent: April 6, 2004Assignee: ChromaVision Medical Systems, Inc.Inventors: Bob Ellis, William J. Decker, Gina McLaren
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Patent number: 6631203Abstract: A method for automated image analysis of a biological specimen by histological reconstruction. Also provided is an automated cell image method for analyzing a biological specimen that has consecutively been stained by either an in situ hybridization (ISH) method, or an immunohistochemistry (IHC) method or a nucleic acid stain, and counterstained. The method couples composite images in an automated manner for processing and analysis. To identify structure in tissue that cannot be captured in a single field of view image or a single staining technique, the disclosure provides a method for histological reconstruction to analyze many fields of view on potentially many slides simultaneously.Type: GrantFiled: February 20, 2002Date of Patent: October 7, 2003Assignee: ChromaVision Medical Systems, Inc.Inventors: Bob Ellis, William J. Decker, Gina McLaren
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Patent number: 6546123Abstract: A method, system, and apparatus are provided for automated light microscopic for detection of proteins associated with cell proliferative disorders.Type: GrantFiled: July 12, 2000Date of Patent: April 8, 2003Assignee: ChromaVision Medical Systems, Inc.Inventors: Gina McLaren, Robert Ellis
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Patent number: 6418236Abstract: A method for automated image analysis of a biological specimen by histological reconstruction. Also provided is an automated cell image method for analyzing a biological specimen that has consecutively been stained by either an in situ hybridization (ISH) method, or an immunohistochemistry (IHC) method or a nucleic acid stain, and counterstained. The method couples composite images in an automated manner for processing and analysis. To identify structure in tissue that cannot be captured in a single field of view image or a single staining technique, the disclosure provides a method for histological reconstruction to analyze many fields of view on potentially many slides simultaneously.Type: GrantFiled: June 24, 1999Date of Patent: July 9, 2002Assignee: ChromaVision Medical Systems, Inc.Inventors: Bob Ellis, William Decker, Gina McLaren
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Publication number: 20020076092Abstract: A method for automated image analysis of a biological specimen by histological reconstruction. Also provided is an automated cell image method for analyzing a biological specimen that has consecutively been stained by either an in situ hybridization (ISH) method, or an immunohistochemistry (IHC) method or a nucleic acid stain, and counterstained. The method couples composite images in an automated manner for processing and analysis. To identify structure in tissue that cannot be captured in a single field of view image or a single staining technique, the disclosure provides a method for histological reconstruction to analyze many fields of view on potentially many slides simultaneously.Type: ApplicationFiled: February 20, 2002Publication date: June 20, 2002Applicant: Chroma Vision Medical Systems, Inc., a California corporationInventors: Bob Ellis, William J. Decker, Gina McLaren