Patents by Inventor Gina Zhang

Gina Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12121510
    Abstract: The present invention generally relates to sensitizer compounds and their use to sensitize cancer and/or pre-cancerous cells of certain cancers to treatment with certain resistance-prone therapeutics used in cancer therapy. In embodiments, the conjugates of particular esters or amides of Near Infrared Dyes, are used as sensitizers to avoid or overcome therapeutic resistance once formed. In embodiments, the sensitizers include conjugates with Cisplatin, Simvastatin, Artemisinin, platin-based compounds or statins. In embodiments, the resistance prone cancer therapeutics include cisplatin, gemcitabine, doxorubicin, paclitaxel, docetaxel, and platin-based compounds. These may be administered in combination with the sensitizer, or the sensitizer itself may comprise an therapeutic-derived moiety conjugated to the sensitizer, for example as is the case for dye-CIS conjugated sensitizers. Alternatively, the sensitizer may be co-administered with one or more therapeutic.
    Type: Grant
    Filed: October 21, 2017
    Date of Patent: October 22, 2024
    Assignees: Da Zen Theranostics, Inc., Cedars-Sinai Medical Center
    Inventors: Liyuan Yin, Yi Zhang, Stefan Mrdenovic, Gina Chia Yi Chu, Ruoxiang Wang, Qinghua Zhou, Jian Zhang, Leland W. K. Chung
  • Publication number: 20240261263
    Abstract: The present invention generally relates to sensitizer compounds and their use in combination with Tyrosine Kinase Inhibitors (TKIs) for sensitizing tumor, cancer or pre-cancerous cells to TKI treatment. In particular, the present invention relates to administration regimes that combine TKIs such as Gefitinib or Icotinib with TKI-sensitizing DZ1 esters and amides conjugated to statin or platin-based drugs, or to Artemisinin, including, without limitation: DZ1-Simvastatin amide, DZ1-Simvastatin ester, DZ1-Cisplatin ester, and DZ1-Cisplatin amide, DZ1-Artemisinin ester, and DZ1-Artemisinin amide. Furthermore, the present invention relates to improved TKI treatment of cancers by sensitizing tumor, cancer or pre-cancerous cells, in particular cancers that develop TKI resistance, including e.g. lung cancer and pancreatic cancer.
    Type: Application
    Filed: December 6, 2023
    Publication date: August 8, 2024
    Inventors: Liyuan Yin, Yi Zhang, Stefan Mrdenovic, Gina Chi-Yi Chu, Ruoxiang Wang, Qinghua Zhou, Jian Zhang, Leland W.K. Chung
  • Publication number: 20180154051
    Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.
    Type: Application
    Filed: October 30, 2017
    Publication date: June 7, 2018
    Inventors: Syed F.A. Hossainy, Fuh-Wei Tang, Lothar W. Kleiner, Thierry Glauser, Yiwen Tang, Wouter E. Roorda, Stephen D. Pacetti, Gina Zhang, Yung-Ming Chen, Andrew F. McNiven, Sean A. McNiven, Brandon J. Yoe
  • Patent number: 9821091
    Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: November 21, 2017
    Assignee: Abbot Cardiovascular Systems Inc.
    Inventors: Syed F. A. Hossainy, Fuh-Wei Tang, Lothar W. Kleiner, Thierry Glauser, Yiwen Tang, Wouter E. Roorda, Stephen D. Pacetti, Gina Zhang, Yung-Ming Chen, Andrew F. McNiven, Sean A. McNiven, Brandon J. Yoe
  • Publication number: 20150132249
    Abstract: A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.
    Type: Application
    Filed: January 6, 2015
    Publication date: May 14, 2015
    Inventors: Gina Zhang, Jessica Renee DesNoyer, Gordon Stewart, Maricela Kezis, Syed Faiyaz Ahmed Hossainy
  • Patent number: 8936780
    Abstract: A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: January 20, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Gina Zhang, Jessica Renee DesNoyer, Gordon Stewart, Maricela Kezis, Syed Faiyaz Ahmed Hossainy
  • Patent number: 8815274
    Abstract: The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: August 26, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Jessica R. DesNoyer, Stephen D. Pacetti, Lothar W. Kleiner, Syed F. A. Hossainy, Yung-Ming Chen, Gordon Stewart, Gina Zhang
  • Patent number: 8685428
    Abstract: A method of making a therapeutic composition, as well as the therapeutic composition so made, is disclosed. The method comprises mixing a hydrophobic drug with an aqueous buffer solution and adding a surfactant to the aqueous buffer solution to form the therapeutic composition. A implantable medical device with the therapeutic composition and a method of making a coating for an implantable medical device containing the therapeutic composition is also disclosed.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: April 1, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Gina Zhang, Syed F. A. Hossainy, Eugene Park, Qi Wang
  • Publication number: 20140004250
    Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.
    Type: Application
    Filed: July 29, 2013
    Publication date: January 2, 2014
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: Syed F.A. Hossainy, Fuh-Wei Tang, Lothar W. Kleiner, Thierry Glauser, Yiwen Tang, Wouter E. Roorda, Stephen D. Pacetti, Gina Zhang, Yung-Ming Chen, Andrew F. McNiven, Sean A. McNiven, Brandon J. Yoe
  • Patent number: 8586069
    Abstract: Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.
    Type: Grant
    Filed: December 29, 2005
    Date of Patent: November 19, 2013
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Gordon Stewart, Gina Zhang, Nancy Kirsten, Paul Consigny, Stephen Dugan, Gene Park, Christopher Feezor, Wouter Roorda, Syed Faiyaz Ahmed Hossainy
  • Patent number: 8435550
    Abstract: A drug-delivery system is provided including at least 100 ?g of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a stent. Also provided a method of treating restenosis or vulnerable plaque of a blood vessel, the method includes locally administering to a patient a first drug selected from a group consisting of rapamycin (sirolimus), Biolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, zotarolimus (ABT-578), 40-O-(2-hydroxy)ethylrapamycin (everolimus), 40-O-(3-hydroxy)propylrapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethylrapamycin, 40-O-tetrazolylrapamycin and 40-epi-(N1-tetrazolyl)rapamycin, and locally administering to a patient a second drug consisting of clobetasol, wherein the minimum amount of the first drug that is locally administered is 100 ?g, and wherein the ratio of the first drug to the second drug is, for example, 10:1 to 100:1 (w/w).
    Type: Grant
    Filed: August 13, 2008
    Date of Patent: May 7, 2013
    Assignee: Abbot Cardiovascular Systems Inc.
    Inventors: Jin Cheng, Stephen Dugan, Gordon Stewart, Gina Zhang, Nancy Kirsten, Paul Consigny, Christopher Feezor, Gene Park, Wouter Roorda, Syed F. A. Hossainy
  • Patent number: 8017140
    Abstract: Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: September 13, 2011
    Assignee: Advanced Cardiovascular System, Inc.
    Inventors: Syed Faiyaz Ahmed Hossainy, Gordon Stewart, Deborah Kilpatrick, Jeffrey Ellis, Gene Park, Gina Zhang, Paul Consigny, Yiwen Tang
  • Patent number: 7749263
    Abstract: Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom.
    Type: Grant
    Filed: January 7, 2008
    Date of Patent: July 6, 2010
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Jessica Renee DesNoyer, Stephen Dirk Pacetti, Syed Faiyaz Shmed Hossainy, Lothar Kleiner, Yiwen Tang, Gina Zhang
  • Publication number: 20090297583
    Abstract: The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.
    Type: Application
    Filed: June 4, 2009
    Publication date: December 3, 2009
    Inventors: JESSICA R. DesNoyer, Stephen D. Pacetti, Lothar W. Kleiner, Syed F.A. Hossainy, Yung-Ming Chen, Gordon Stewart, Gina Zhang
  • Publication number: 20090286761
    Abstract: A drug-delivery system is provided including at least 100 ?g of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a stent. Also provided a method of treating restenosis or vulnerable plaque of a blood vessel, the method includes locally administering to a patient a first drug selected from a group consisting of rapamycin (sirolimus), Biolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, zotarolimus (ABT-578), 40-O-(2-hydroxy)ethylrapamycin (everolimus), 40-O-(3-hydroxy)propylrapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethylrapamycin, 40-O-tetrazolylrapamycin and 40-epi-(N1-tetrazolyl)rapamycin, and locally administering to a patient a second drug consisting of clobetasol, wherein the minimum amount of the first drug that is locally administered is 100 ?g, and wherein the ratio of the first drug to the second drug is, for example, 10:1 to 100:1 (w/w).
    Type: Application
    Filed: August 13, 2008
    Publication date: November 19, 2009
    Inventors: Jin Cheng, Stephen Dugan, Gordon Stewart, Gina Zhang, Nancy Kirsten, Paul Consigny, Christopher Feezor, Gene Park, Wouter Roorda, Syed F.A. Hossainy
  • Publication number: 20090104240
    Abstract: The present invention relates to implantable medical devices coated with the polymer containing at least an olimus and a corticosteroid for the treatment of vascular diseases.
    Type: Application
    Filed: October 19, 2007
    Publication date: April 23, 2009
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: Gordon Stewart, Syed F.A. Hossainy, Benjamyn Serna, Mikael Trollsas, Jessica R. Desnoyer, Leslie Coleman, Gina Zhang, Maricela Kezis
  • Publication number: 20080167712
    Abstract: Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom.
    Type: Application
    Filed: January 7, 2008
    Publication date: July 10, 2008
    Inventors: Jessica Renee DesNoyer, Stephen Dirk Pacetti, Syed Faiyaz Shmed Hossainy, Lothar Kleiner, Yiwen Tang, Gina Zhang
  • Patent number: 7390497
    Abstract: Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the PEA. The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: June 24, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Jessica Renee DesNoyer, Stephen Dirk Pacetti, Syed Faiyaz Shmed Hossainy, Lothar Kleiner, Yiwen Tang, Gina Zhang
  • Publication number: 20080124372
    Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.
    Type: Application
    Filed: June 6, 2006
    Publication date: May 29, 2008
    Inventors: Syed F. A. Hossainy, Fuh-Wei Tang, Lothar Kleiner, Thierry Glauser, Yiwen Tang, Wouter Roorda, Stephen Pacetti, Gina Zhang, Yung-Ming Chen, Andrew F. McNiven, Sean A. McNiven, Brandon J. Yoe
  • Publication number: 20080057024
    Abstract: A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.
    Type: Application
    Filed: August 30, 2006
    Publication date: March 6, 2008
    Inventors: Gina Zhang, Jessica Renee DesNoyer, Gordon Stewart, Maricela Kezis, Syed Faiyaz Ahmed Hossainy