Patents by Inventor Ginger Abraham
Ginger Abraham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120135045Abstract: Bioengineered collagen constructs with antimicrobial properties are provided. The bioengineered collagen constructs comprise a sheet-like layer of purified collagenous tissue matrix derived from a tissue source, such as the tunica submucosa of small intestine or a processed intestinal collagen layer derived from the tunica submucosa of small intestine, treated with an antimicrobial agent. The constructs are biocompatible. The present invention has a variety of applications, including wound dressing and surgical repair devices. Methods for treating a damaged or diseased soft tissue are provided. Methods for treating a wound in need of care and treatment are also disclosed.Type: ApplicationFiled: June 21, 2011Publication date: May 31, 2012Applicant: Organogenesis, Inc.Inventors: Andrew J. Nixon, Ginger A. Abraham-Freel, Patrick R. Bilbo
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Publication number: 20090311298Abstract: Bioengineered collagen constructs with antimicrobial properties are provided. The bioengineered collagen constructs comprise a sheet-like layer of purified collagenous tissue matrix derived from a tissue source, such as the tunica submucosa of small intestine or a processed intestinal collagen layer derived from the tunica submucosa of small intestine, treated with an antimicrobial agent. The constructs are biocompatible. The present invention has a variety of applications, including wound dressing and surgical repair devices. Methods for treating a damaged or diseased soft tissue are provided. Methods for treating a wound in need of care and treatment are also disclosed.Type: ApplicationFiled: October 18, 2006Publication date: December 17, 2009Applicant: Oranogenesis, In.cInventors: Andrew J. Nixon, Ginger A. Abraham-Freel, Patrick R. Bilbo
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Patent number: 7214242Abstract: The invention is directed to bioengineered tubular graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.Type: GrantFiled: March 3, 2003Date of Patent: May 8, 2007Assignee: Organogenesis, Inc.Inventors: Ginger A. Abraham, Robert M. Carr, Jr.
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Publication number: 20070003633Abstract: An apparatus for forming a tube construct from a planar sheet matrix includes a stand supporting two opposing mounts and spanning between the opposing mounts are a mandrel, a porous rod, and a spring-loaded roller held in parallel arrangement; a guide for aligning and engaging the mandrel on the opposing mounts; and a means for imparting a tangential force on the planar sheet matrix to prevent wrinkling. The porous rod has a lumen running its length and has pores that communicate between the lumen of the porous rod through to the surface of the rod for water to uniformly pass through. The spring-loaded roller runs along the length of the porous rod creating a line of contact between the roller and the mandrel. The mandrel is contacted with a planar sheet of matrix and is rotated such that successive portions of the matrix contact the porous rod and become lightly moistened by the water passing through the pores of the porous rod and become wrapped around the mandrel to form a tube construct.Type: ApplicationFiled: April 14, 2005Publication date: January 4, 2007Inventors: Ginger Abraham, Maury Cosman, Kristen Billiar, Ryan Mercer, Bruce Miller
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Patent number: 7121999Abstract: The invention is directed to bioengineered graft prostheses made from two or more superimposed, chemically bonded layers of processed tissue material prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.Type: GrantFiled: March 3, 2003Date of Patent: October 17, 2006Assignee: Organogenesis Inc.Inventors: Ginger A. Abraham, James Murray, Nathaniel M. Bachrach
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Publication number: 20060100717Abstract: The invention is directed to bioengineered graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or use in a mammalian host.Type: ApplicationFiled: November 23, 2005Publication date: May 11, 2006Applicant: Organogenesis, Inc.Inventors: Ginger Abraham, Susan Sullivan, James Murray
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Patent number: 7041131Abstract: The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.Type: GrantFiled: April 11, 2003Date of Patent: May 9, 2006Assignee: Organogenesis, Inc.Inventors: Ginger A. Abraham, Robert M. Carr, Jr., Tam Huynh, Per Otto Hagen, Mark Davies
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Publication number: 20060024380Abstract: The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.Type: ApplicationFiled: May 16, 2005Publication date: February 2, 2006Applicant: Organogenesis Inc.Inventors: Ginger Abraham, Robert Carr, Paul Kemp, Ryan Mercer, Linda Baker
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Patent number: 6986735Abstract: The invention is directed to methods of making bioremodelable graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or use in a mammalian host.Type: GrantFiled: March 3, 2003Date of Patent: January 17, 2006Assignee: Organogenesis Inc.Inventors: Ginger A. Abraham, Susan J. Sullivan, James Murray
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Patent number: 6893653Abstract: The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.Type: GrantFiled: July 8, 2003Date of Patent: May 17, 2005Assignee: Organogenesis Inc.Inventors: Ginger A. Abraham, Robert M. Carr, Jr., Paul D. Kemp, Ryan D. Mercer, Linda Baker
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Publication number: 20040005703Abstract: The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.Type: ApplicationFiled: July 8, 2003Publication date: January 8, 2004Applicant: Organogenesis, Inc.Inventors: Ginger A. Abraham, Robert M. Carr, Paul D. Kemp, Ryan D. Mercer, Linda Baker
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Publication number: 20030195618Abstract: The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.Type: ApplicationFiled: April 11, 2003Publication date: October 16, 2003Applicants: Organogenesis, Inc., Duke University School of MedicineInventors: Ginger A. Abraham, Robert M. Carr, Tam Huynh, Per Otto Hagen, Mark Davies
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Publication number: 20030171824Abstract: The invention is directed to bioengineered tubular graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.Type: ApplicationFiled: March 3, 2003Publication date: September 11, 2003Applicant: Organogenesis, Inc.Inventors: Ginger A. Abraham, Robert M. Carr
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Publication number: 20030167088Abstract: The invention is directed to bioengineered graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or use in a mammalian host.Type: ApplicationFiled: March 3, 2003Publication date: September 4, 2003Applicant: Organogenesis, Inc.Inventors: Ginger A. Abraham, Susan J. Sullivan, James Murray
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Patent number: 6599690Abstract: The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.Type: GrantFiled: November 30, 1999Date of Patent: July 29, 2003Assignee: Organogenesis Inc.Inventors: Ginger A. Abraham, Robert M. Carr, Jr., Paul D. Kemp, Ryan Mercer, Linda Baker
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Publication number: 20030130747Abstract: The invention is directed to bioengineered graft prostheses made from two or more superimposed, chemically bonded layers of processed tissue material prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.Type: ApplicationFiled: March 3, 2003Publication date: July 10, 2003Applicant: Organogenesis, Inc.Inventors: Ginger A. Abraham, James Murray, Nathaniel M. Bachrach
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Patent number: 6572650Abstract: The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.Type: GrantFiled: June 11, 2001Date of Patent: June 3, 2003Assignees: Organogenesis Inc., Duke University School of MedicineInventors: Ginger A. Abraham, Robert M. Carr, Jr., Tam Huynh, Otto Per Hagen, Mark Davies
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Patent number: 5993844Abstract: The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.Type: GrantFiled: May 8, 1997Date of Patent: November 30, 1999Assignee: Organogenesis, Inc.Inventors: Ginger A. Abraham, Robert M. Carr, Jr., Paul D. Kemp, Ryan Mercer, Linda Baker