Patents by Inventor Gino Bradica
Gino Bradica has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11660100Abstract: Disclosed are radially expanding debridement tools configured to pass through an access channel present in a first tissue of a living being, expand radially, and create a void in a second tissue of the living being upon being advanced distally through the access channel and into the second tissue while being rotated, wherein the shape of the void comprises at least one step. Further disclosed are debridement systems and methods of treating tissue defects in living beings.Type: GrantFiled: January 25, 2019Date of Patent: May 30, 2023Assignee: DSM IP ASSETS B.V.Inventors: William T. Fisher, Timothy Ringeisen, Gino Bradica
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Publication number: 20230159881Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.Type: ApplicationFiled: January 9, 2023Publication date: May 25, 2023Inventors: John E. NASH, William T. FISHER, Gino BRADICA
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Patent number: 11549094Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.Type: GrantFiled: June 5, 2020Date of Patent: January 10, 2023Assignee: DSM IP ASSETS B.V.Inventors: John E. Nash, William T. Fisher, Gino Bradica
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Publication number: 20210077123Abstract: Disclosed are radially expanding debridement tools configured to pass through an access channel present in a first tissue of a living being, expand radially, and create a void in a second tissue of the living being upon being advanced distally through the access channel and into the second tissue while being rotated, wherein the shape of the void comprises at least one step. Further disclosed are debridement systems and methods of treating tissue defects in living beings.Type: ApplicationFiled: January 25, 2019Publication date: March 18, 2021Inventors: William T. FISHER, Timothy RINGEISEN, Gino BRADICA
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Publication number: 20200299632Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.Type: ApplicationFiled: June 5, 2020Publication date: September 24, 2020Inventors: John E. NASH, William T. FISHER, Gino BRADICA
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Patent number: 10711239Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.Type: GrantFiled: April 10, 2018Date of Patent: July 14, 2020Assignee: DSM IP ASSETS B.V.Inventors: John E. Nash, William T. Fisher, Gino Bradica
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Patent number: 10125345Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.Type: GrantFiled: January 30, 2015Date of Patent: November 13, 2018Assignee: DSM IP ASSETS, B.V.Inventors: John E. Nash, William T. Fisher, Gino Bradica
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Publication number: 20180230418Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.Type: ApplicationFiled: April 10, 2018Publication date: August 16, 2018Inventors: John E. Nash, William T. Fisher, Gino Bradica
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Patent number: 10016278Abstract: Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant.Type: GrantFiled: June 30, 2009Date of Patent: July 10, 2018Assignee: DSM IP ASSETS B.V.Inventors: Gino Bradica, William Christian Wattengel, Timothy A. Ringeisen
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Publication number: 20170368183Abstract: An implant for promoting accelerated wound healing. The implant comprises a non-flocculating fiber material, admixed with a settable fluid. The fiber component typically will have short fiber lengths, so as to avoid forming entangled masses or clumps when mixed with a fluid. In an embodiment, the fiber material is native collagen fibers and the settable fluid is an isolated blood fraction, such as platelet rich plasma and platelet poor plasma. The native collagen fiber retaining the native crosslinks of the source tissue and providing an architectural and structural scaffolding for advancing cellular infiltration. The wound healing implant will accelerate the bodies healing process, to provide better healing and less scar tissue of the wound site.Type: ApplicationFiled: August 16, 2017Publication date: December 28, 2017Inventors: Gino BRADICA, Ryan Andrew SASKA, Christopher DIJIACOMO, Timothy A. RINGEISEN
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Patent number: 9782196Abstract: Improved coring devices suitable for articular cartilage and bone, wherein the cutting device is capable of slicing through a tough protective tangential zone, delicately separating the shock absorbing columns of cells in the radial zone of the cartilage, and finally cutting into the hard underlying bone in a manner that preserves the viability of osteochondral cells. The coring device features an annulus having a flat annular cutting edge interrupted by at least one serration having neutral cutting angles. A method for concurrently removing cartilaginous and bony tissue using an improved coring device that preserves the viability of osteochondral cells.Type: GrantFiled: February 17, 2006Date of Patent: October 10, 2017Assignee: DSM IP ASSETS B.V.Inventors: Gino Bradica, Timothy A. Ringeisen
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Publication number: 20150218506Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.Type: ApplicationFiled: January 30, 2015Publication date: August 6, 2015Inventors: JOHN E. NASH, WILLIAM T. FISHER, GINO BRADICA
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Patent number: 9017417Abstract: This invention includes a subchondral bone repair system, comprising a structural component and a fluid settable component and an optional non-core component. The fluid settable component may penetrate into any pores of the structural component, and set to a solid, thereby fixing the structural component in place. The fluid settable component will penetrate interporously into the pores of the subchondral bone tissue surrounding the device, beneficially displacing any fluid to reduce edema in the affected bone region. Furthermore, the settable component, once solid is osteoconductive to promote repair and regrowth of bone in the affected region, and will also transmit mechanical force stimuli (such as compressive forces) directed through the structural component, into the adjacent bone tissue, thereby providing appropriate force stimuli necessary for appropriate tissue growth.Type: GrantFiled: May 30, 2012Date of Patent: April 28, 2015Assignee: Kensey Nash BVF Technology LLCInventors: Gino Bradica, Timothy A. Ringeisen
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Patent number: 8795242Abstract: An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. In one embodiment, the device is arranged for the local delivery of therapeutic agent. A preferred embodiment is a porous resorbable implant, wherein the therapy delivery may be localized in nature, rather than systemic, such that higher doses at the target site may be allowed than would be tolerable by the body systemically.Type: GrantFiled: February 12, 2005Date of Patent: August 5, 2014Assignee: Kensey Nash CorporationInventors: David M. Hoganson, Gino Bradica, Scott M. Goldman, John H. Brekke
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Patent number: 8795364Abstract: A system for repairing a vertebral disc defect, such as hernia or bulge, a full or partial tear in the annulus, or a weakened annulus wall as a result of an excision procedure. The system introduces a treatment device arranged to repair the defect, and may prevent the leakage of fluid from the nucleus. The components of the device may be resorbable materials, and may induce the ingrowth of cellular material into the components. The system may feature a locating device to ensure proper placement of the treatment device.Type: GrantFiled: May 6, 2005Date of Patent: August 5, 2014Assignee: Kensey Nash CorporationInventors: Douglas G. Evans, Gino Bradica, Jeffrey C. Kelly, Michael K. Carouge
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Publication number: 20140186455Abstract: An implant for promoting accelerated wound healing. The implant comprises a non-flocculating fiber material, admixed with a settable fluid. The fiber component typically will have short fiber lengths, so as to avoid forming entangled masses or clumps when mixed with a fluid. In an embodiment, the fiber material is native collagen fibers and the settable fluid is an isolated blood fraction, such as platelet rich plasma and platelet poor plasma. The native collagen fiber retaining the native crosslinks of the source tissue and providing an architectural and structural scaffolding for advancing cellular infiltration. The wound healing implant will accelerate the bodies healing process, to provide better healing and less scar tissue of the wound site.Type: ApplicationFiled: December 31, 2012Publication date: July 3, 2014Inventors: Gino Bradica, Ryan Saska, Christopher DiJiacomo, Timothy A. Ringeisen
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Patent number: 8758351Abstract: A system for repairing a vertebral disc defect, such as hernia or bulge, a full or partial tear in the annulus, or a weakened annulus wall as a result of an excision procedure. The system introduces a treatment device arranged to repair the defect, and may prevent the leakage of fluid from the nucleus. The components of the device may be resorbable materials, and may induce the ingrowth of cellular material into the components. The system may feature a locating device to ensure proper placement of the treatment device.Type: GrantFiled: February 14, 2012Date of Patent: June 24, 2014Assignee: Kensey Nash CorporationInventors: Douglas G. Evans, Jeffrey C. Kelly, Gino Bradica, Michael K. Carouge, Brian Oeffinger
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Patent number: 8672941Abstract: Improved coring devices suitable for articular cartilage and bone, wherein the cutting device is capable of slicing through a tough protective tangential zone, delicately separating the shock absorbing columns of cells in the radial zone of the cartilage, and finally cutting into the hard underlying bone in a manner that preserves the viability of osteochondral cells. The coring device features an annulus having a flat annular cutting edge interrupted by at least one serration having neutral cutting angles. A method for concurrently removing cartilaginous and bony tissue using an improved coring device that preserves the viability of osteochondral cells.Type: GrantFiled: February 2, 2005Date of Patent: March 18, 2014Assignee: Kensey Nash BVF Technology LLCInventors: Gino Bradica, Timothy A. Ringeisen
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Publication number: 20130325126Abstract: This invention includes a subchondral bone repair system, comprising a structural component and a fluid settable component and an optional non-core component. The fluid settable component may penetrate into any pores of the structural component, and set to a solid, thereby fixing the structural component in place. The fluid settable component will penetrate interporously into the pores of the subchondral bone tissue surrounding the device, beneficially displacing any fluid to reduce edema in the affected bone region. Furthermore, the settable component, once solid is osteoconductive to promote repair and regrowth of bone in the affected region, and will also transmit mechanical force stimuli (such as compressive forces) directed through the structural component, into the adjacent bone tissue, thereby providing appropriate force stimuli necessary for appropriate tissue growth.Type: ApplicationFiled: May 30, 2012Publication date: December 5, 2013Inventors: Gino Bradica, Timothy A. Ringeisen
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Patent number: 8403996Abstract: An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. A preferred embodiment includes a cartilage region comprising a polyelectrolytic complex joined with a subchondral bone region. The cartilage region, of this embodiment, enhances the environment for chondrocytes to grow articular cartilage; while the subchondral bone region enhances the environment for cells which migrate into that region's macrostructure and which differentiate into osteoblasts. A hydrophobic barrier exists between the regions, of this embodiment. In one embodiment, the polyelectrolytic complex transforms to hydrogel, following the implant procedure.Type: GrantFiled: November 29, 2006Date of Patent: March 26, 2013Assignee: Kensey Nash CorporationInventors: John H. Brekke, Gino Bradica, Scott M. Goldman