Patents by Inventor Gino M. Salituro

Gino M. Salituro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indolylquinones as antidiabetic agents
    Patent number: 6051597
    Abstract: Indolylquinones are useful for the treatment and prevention of diabetes mellitus, and in particular, for the treatment or prevention of hyperglycemia in diabetic patients. Some of the indolylquinones are produced by fermentation of the novel fungus Pseudomassaria sp. ATCC 74411.
    Type: Grant
    Filed: June 10, 1998
    Date of Patent: April 18, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Bei Zhang, Royo Inmaculada, Fernando Pelaez, Gino M. Salituro, Gerald F. Bills
  • Unguinol and analogs are animal growth permittants
    Patent number: 5350763
    Abstract: Unguinol is a well-known metabolite of the fungi Aspergillus unguis and Aspergillus nidulans. Unguinol has been found to be an active growth permittant and promotant in animals, in particular, monogastric animals such as chickens. In addition, the fermentation broth also produced the additional known unguinol derivatives of folipastatin and 2-chloro unguinol as well as the novel 4-methyl derivative. All of these compounds are active animal growth permittants. Compositions containing such unguinol derivatives for use as growth permittants and promotants are also disclosed.
    Type: Grant
    Filed: June 11, 1993
    Date of Patent: September 27, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Scott D. Feighner, Gino M. Salituro, Jack L. Smith, Nancy N. Tsou
  • Oxytocin antagonists
    Patent number: 5198463
    Abstract: A method for inhibiting oxytocin activity by administering an oxytocin inhibiting amount of a penicillide compound having the formula ##STR1## and compositions for such use are described.
    Type: Grant
    Filed: March 30, 1992
    Date of Patent: March 30, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Douglas J. Pettibone, Gino M. Salituro
  • Process for producing FK-506
    Patent number: 5194378
    Abstract: Described is a new process for producing the macrolide immunosuppressant, FK-506 under fermentation conditions utilizing the microorganism, Streptomyces sp., (Merck Culture Collection No. MA 6858) ATCC No. 55098. The immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
    Type: Grant
    Filed: October 7, 1991
    Date of Patent: March 16, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Gino M. Salituro, Francis Dumont, George M. Garrity, Leeyuan Huang, E. Tracy T. Jones, Mary N. Omstead, Isabel M. Fernandez, Teresa D. Matas