Patents by Inventor Gintautas Tamulaitis

Gintautas Tamulaitis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted RNA knockdown and knockout by type III-A Csm complexes
    Patent number: 11274317
    Abstract: Methods and compositions using a CRISPR-Cas Type IIIA resulting in RNA gene knockdown and knockout in an animal.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: March 15, 2022
    Assignee: VILNIUS UNIVERSITY
    Inventors: Thomas Fricke, Matthias Bochtler, Gintautas Tamulaitis, Miglé Kazlauskiene, Virginijus {hacek over (S)}ik{hacek over (s)}nys
  • PRODUCTION OF CYCLIC ADENYLATES AND THEIR USE AS ALLOSTERIC REGULATORS
    Publication number: 20210130799
    Abstract: A method of synthetizing cyclic oligoadenylates using a novel catalytic activity of a protein possessing the Palm domain, such as the Cas10 protein, and using such compounds for activation of proteins possessing the CARF doman, such as the Csm6 protein.
    Type: Application
    Filed: May 31, 2018
    Publication date: May 6, 2021
    Inventors: Virginijus SIKSNYS, Migle KAZLAUSKIENE, Georgij KOSTIUK, Gintautas TAMULAITIS
  • METHOD FOR CLONING AND EXPRESSION OF PFOI RESTRICTION ENDONUCLEASE
    Publication number: 20190300866
    Abstract: This application relates to the isolated DNA encoding the PfoI restriction endonuclease, vectors containing the isolated DNA and host cells expressing the vectors as well as a method for producing recombinant PfoI restriction endonuclease.
    Type: Application
    Filed: March 29, 2019
    Publication date: October 3, 2019
    Inventors: Sonata JURENAITE-URBANAVICIENE, Gintautas TAMULAITIS
  • Programmable RNA shredding by the type III-A CRISPR-Cas system of
    Patent number: 10385336
    Abstract: A Type III-A CRISPR-Cas (StCsm) complex of Streptococcus thermophilus comprising crRNA, Csm4, and Csm3 and use for cleavage of RNA bearing a nucleotide sequence complementary to the crRNA, in vitro or in vivo. Methods for site-specific cleavage/shredding of a target RNA molecule using an RNA-guided RNA endonuclease comprising a minimal complex of crRNA, Csm4, and Csm3, and methods of RNA knock-down and RNA knock-out are disclosed.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: August 20, 2019
    Assignee: VILNIUS UNIVERSITY
    Inventors: Virginijus Siksnys, Migle Kazlauskiene, Gintautas Tamulaitis
  • TARGETED RNA KNOCKDOWN AND KNOCKOUT BY TYPE III-A Csm COMPLEXES
    Publication number: 20180105835
    Abstract: Methods and compositions using a CRISPR-Cas Type IIIA resulting in RNA gene knockdown and knockout in an animal.
    Type: Application
    Filed: August 31, 2017
    Publication date: April 19, 2018
    Inventors: Thomas FRICKE, Matthias BOCHTLER, Gintautas TAMULAITIS, Migle KAZLAUSKIENE, Virginijus SIKSNYS
  • Programmable RNA Shredding by the Type III-A CRISPR-Cas System of Streptococcus Thermophilus
    Publication number: 20170198286
    Abstract: A Type III-A CRISPR-Cas (StCsm) complex of Streptococcus thermophilus comprising crRNA, Csm4, and Csm3 and use for cleavage of RNA bearing a nucleotide sequence complementary to the crRNA, in vitro or in vivo. Methods for site-specific cleavage/shredding of a target RNA molecule using an RNA-guided RNA endonuclease comprising a minimal complex of crRNA, Csm4, and Csm3, and methods of RNA knock-down and RNA knock-out are disclosed.
    Type: Application
    Filed: March 3, 2017
    Publication date: July 13, 2017
    Inventors: Virginijus Siksnys, Migle Kazlauskiene, Gintautas Tamulaitis